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Changes in serum biochemical and hematological parameters were studied in 20 male rhesus monkeys following acute poisoning
by the organophosphate nerve agent cyclohexylmethylphosphonofluoridate (CMPF or GF). Animals were challenged with 5×LD50 GF
(233 μg/kg, IM) following pretreatment with pyridostigmine (0.3–0.7 mg/kg per 24 h) and treated with atropine (0.4 mg/kg,
IM) and either 2-PAM (25.7 mg/kg, IM) or HI6 (37.8 mg/kg, IM) at the onset of clinical signs or at 1 min after exposure. Muscle
fasciculations, tremors, or convulsions occurred in 19 of 20 animals. Serum biochemical and hematologic parameters were analyzed
2 days and 7 days after exposure and compared to pre-exposure baseline values. Significant increases in creatine kinase (CK),
lactate dehydrogenase (LD), aspartate transaminase (AST), alanine transaminase (ALT) and potassium ion (K+), associated with damage to striated muscle and metabolic acidosis, occurred in both oxime-treated groups 2 days after exposure.
Total protein, albumin, red blood cell (RBC) count, hemoglobin concentration (Hb) and hematocrit (Hct), were decreased in
both oxime-treated groups at 7 days. The results demonstrate that animals exposed to a single high dose of GF and treated
with standard therapy exhibit changes in serum biochemical and hematological indices directly and indirectly associated with
their clinical presentations.
Received: 15 November 1993 / Accepted: 29 August 1994 相似文献
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新鲜血液样本在不同血液分析仪上进行室内质控的探讨 总被引:1,自引:0,他引:1
目的 :探讨使用新鲜血液样本在不同血液分析仪上进行室内质控的方法。方法 :选用CD 16 0 0型血液分析仪做参考机 ,用同一份新鲜血液样本在参考机上测定后 ,用CD 35 0 0型血液分析仪、K 45 0 0型血液分析仪、CA6 2 0型血液分析仪进行测定 ,将结果与参考机结果进行比较 ,以相差百分比绘制质控图 ,根据标准判断结果是否出控。结果 :各型血液分析仪检测结果可达到以下要求 :RBC :CD 16 0 0所测结果± 4% ,WBC :CD 16 0 0所测结果± 6 % ,HGB :CD 16 0 0所测结果± 3% ,PLT :CD 16 0 0所测结果± 13%。结论 :利用新鲜血液样本在不同仪器上进行室内质控 ,是一项简便易行的质控方法 相似文献
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在血液病学的临床教学工作中,通过应用循证医学原则,提高了学员对疾病的诊断和治疗策略制定过程的认识,同时也锻炼其临床逻辑思维能力。 相似文献
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自体输血的实验研究 总被引:2,自引:0,他引:2
目的 观察体腔血自体回输对凝血纤溶功能的影响和肝肾功能的变化,以及预存自体血回输患者血液学参数的变化,为临床应用提供参考依据。方法 (1)选择内出血病例30例,随机分为两组、组1(n=15)回输自体血600ml~2600ml,另加库存血300ml~1000ml;组2(n=15)输库存血600ml~1600ml。在术前、术后即刻(组2术终)和术后48h采集静脉血标本,测定红细胞(RBC)和血小板(Plt)计数;纤维蛋白原(Fbg)、红细胞球压积(Hct)、游离血红蛋白(FHb)、血小板最大聚集率(Plt-MAR);白陶土部分凝血活酶时间(KPTT)、凝血酶原时间(PT)、凝血酶时间(TT);优球蛋白溶解时间(ELT)和硫酸鱼精蛋白副凝固试验(3P)等各项指标,同时观察体腔血及其过滤后上述指标的变化;术后48h测定谷丙转氨酶(GPT)、肌酐(Cr)、血尿素氮(BuN)和血钾含量。(2)选择择期手术患者138例,在采血前、后,回输后3d、7d采集血标本,测定RBC、Plt、白细胞(WBC)计数、Hct和Hb。结果 体腔血不凝固,RBC、Fbg和Plt显著下降(P<0.01),Hct显著降低(P<0.05),FHb显著升高(P<0.01),Plt-MAR不聚集;PT、TT超过200s,KPTT超过300s;ELT无反应,3P阴性。体腔血回输后RBC、Hct增高,但无统计学差异。FHb升高,KPTT显著延长(P<0.01),Plt、Fbg显著下降(P<0.05),PT、TT显著延长(P<0.05),Plt-MAR、ELT、3 相似文献
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