全文获取类型
收费全文 | 68篇 |
免费 | 0篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 8篇 |
临床医学 | 1篇 |
内科学 | 2篇 |
神经病学 | 5篇 |
特种医学 | 4篇 |
外科学 | 11篇 |
综合类 | 16篇 |
预防医学 | 5篇 |
药学 | 5篇 |
中国医学 | 6篇 |
肿瘤学 | 8篇 |
出版年
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2017年 | 3篇 |
2016年 | 1篇 |
2013年 | 2篇 |
2012年 | 4篇 |
2011年 | 4篇 |
2010年 | 2篇 |
2008年 | 2篇 |
2006年 | 5篇 |
2005年 | 2篇 |
2003年 | 3篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1988年 | 1篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有73条查询结果,搜索用时 0 毫秒
1.
Eberhard Unsöld Christian Ell Dieter Jocham Ronald Sroka Susanne Stocker 《Lasers in medical science》1990,5(3):309-316
Eight commercially available HPD-photosensitizers intended for photodynamic therapy were tested in a murine tumour model with regard to their therapeutic efficacy. The regrowth delay of the fibrosarcoma SSK-2 on the mouse C3H, Neuherberg-line, was determined 3, 24, 48 and 72 h after injection of the drugs (dose: 9 mg kg–1 body weight). The corresponding pharmacodynamics, as measured by regrowth delay, were approximated by an exponential function and the characterizing coefficients derived. These coefficients served to quantify the photodynamic properties of the drugs.The pharmacodynamics of five substances were compared with those obtained fluorometrically. The latter showed shorter decay constants than the therapy-correlated substances which indicates different metabolic behaviour of the therapeutic and diagnostically useful fluorescent components of haematoporphyrin-derived photosensitizers. 相似文献
2.
目的 研究激光诱导的光动力效应对人癌细胞株的体外杀伤作用及对脐血单个核细胞的影响 ,以探讨自体外周血造血干细胞移植物的体外净化方法。方法 通过MTT法测定观察不同剂量光敏剂 (血卟啉衍生物 ,HPD)经激光照射不同时间后 ,对人白血病细胞株K5 62、乳腺癌细胞株MCF -7及脐血单个核细胞生长抑制作用的影响。结果 单纯光照对 3种细胞均无明显作用 ;单纯加光敏剂对K5 62细胞及MCF -7细胞有一定的抑制生长作用 ;激光照射加光敏剂可显著抑制K5 62细胞及MCF -7细胞的生长 ,且具有时间及浓度依赖性 ,但对脐血单个核细胞则无明显抑制作用。其细胞抑制率依次为K5 62细胞 >MCF -7细胞 >脐血单个核细胞。结论 激光诱导的光动力效应可能为恶性血液病或实体瘤患者的自体外周血造血干细胞移植物体外净化提供简便、有效且经济的方法 ,值得临床推广、应用。 相似文献
3.
A hearing protection fit testing was conducted on workers (n = 189) in a textile factory in southern China. The 3M E-A-Rfit Dual-Ear Validation System was used to measure the personal attenuation rating (PAR) on an over-the-head style earmuff at the work site. In addition, PARs were obtained several times throughout the same work shift to capture different fits on 39 workers. Follow-up visits were conducted in approximate 6-month or 12-month intervals to repeat the fit testing. Both the immediate and residual effects of training on the field attenuation of hearing protection devices obtained by workers, and the effects of training toward improving the attenuation and protection of earmuffs after a period of daily use, were observed. A questionnaire survey was used to assess the awareness of hearing health and motivation toward the use of earmuffs in a high temperature environment. The results showed that there were wide variations in PARs among the workers tested. The one-on-one training together with fit testing improved PAR and helped to reduce the negative impact caused by use of protective hair covers. Since earmuffs are often used for long periods of time (>1 year), repeating fit tests could be helpful in order to verify the attenuation received throughout their useful life. 相似文献
4.
Shuichi Ishiyama Akira Fuse Hiroshi Kuzu Joji Tanaka Masahiro Urayama Yukio Igarashi Fumiaki Sakurai Kiyoshi Kawaguchi Masaru Tsukamoto Tadashi Nakamura Shuji Koike 《Journal of hepato-biliary-pancreatic sciences》1997,4(4):417-422
A microsurgical technique was used in performing anterior hepatic segmentectomy and pancreatoduodenectomy with reconstruction of the posterior hepatic artery in a 64-year-old man with widespread bile duct cancer from the intrapancreatic bile duct over the hepatic hilus. The anterior hepatic artery was obviously involved and the posterior hepatic artery just behind common hepatic duct was very close to the cancer. Microsurgical anastomosis between the remnant gastroduodenal artery and the posterior hepatic artery at the hepatic hilus made it possible to preserve the posterior segment of the liver and to perform a curative resection of the cancer. The patient had pyrexia because of suprahepatic abscess after the operation, but the abscess drained spontaneously. Postoperative arteriogram showed neither obstruction nor kinking of the reconstructed artery. He was discharged 2 months after surgery and has been enjoying a normal quality of life for 10 months since, with no signs of recurrence. It is suggested that a microsurgical technique is useful for performing an accurate anastomosis with good patency that allows not only a safe but also a highly curative operation for advanced bile duct cancer. 相似文献
5.
积极开展中晚期胆囊癌的外科治疗:附32例报告 总被引:18,自引:2,他引:18
目的 多数外科医生对中晚期胆囊癌的外科治疗持消极悲观态度,作者探讨积极采取外科治疗的价值。方法 对32 例中晚期胆囊癌患者进行积极的外科治疗,除胆囊切除外,另行肝段切除术7 例、半肝切除1 例、肝门部胆管切除高位胆肠吻合4 例、肝段切除并肝门部胆管切除高位胆肠吻合6例、肝部分及胰头十二指肠切除14 例。其中26 例行肝十二指肠韧带骨骼化清扫。结果 手术均顺利完成,17 例12 个月前手术者,10 例仍存活,其中2 例已超过30 个月,最长达40 个月;15 例12 个月内手术者14 例存活。结论 对中晚期胆囊癌积极进行根治性手术,能改善其生活质量,延长生存期。 相似文献
6.
本文报告应用两种不同波长激光为 PDT(光动疗法)的激光源,对小鼠移植肿瘤进行杀伤实验。结果表明:在相同光剂量下,HPD—氩离子泵浦的染料激光(波长6 300(?))对肿瘤杀伤的效果强于 HPD—氩离子激光(波长5 145(?))(P<0.01);同一波长激光在光剂量相同时,采用不同的瞬间功率,对肿瘤杀伤的效果相同(P>0.20)。 相似文献
7.
血卟啉衍生物(HPD)加光照对无细胞体系DNA合成的抑制作用 总被引:3,自引:0,他引:3
本文从腹水型肝癌细胞部分纯化了依赖于DNA的DNA聚合酶a,以热变性的小牛胸腺DNA为模板,观察了HPD的光敏效应对这-DNA合成体系的影响。结果表明,单独的HPD或光照对无细胞体系DNA合成无细胞;而既用HPD处理,又经光照后的DNA合成系统表现出明显的抑制作用。此抑制作用呈显著的剂量和时间的依赖效应关系。HPD的光敏反应与DNA模板非竞争性地作用于酶。增加模板量不能使抑制作用逆转;而增加酶量可 相似文献
8.
9.
本文总结了应用光敏技术治疗12例不同类型癌肿的疗效,取得91.7%的有效率,其中消化道肿瘤88.8%.文中结合文献资料进一步分析了光动力学技术诊治恶性肿瘤的重要价值.认为血卟啉一激光光动力学技术不失为一种治疗早期肿瘤和控制晚期肿瘤发展、延缓患者生命并减少其痛苦的有效手段. 相似文献
10.