全文获取类型
收费全文 | 572篇 |
免费 | 8篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 14篇 |
妇产科学 | 4篇 |
基础医学 | 77篇 |
口腔科学 | 11篇 |
临床医学 | 45篇 |
内科学 | 84篇 |
皮肤病学 | 108篇 |
神经病学 | 20篇 |
特种医学 | 38篇 |
外科学 | 50篇 |
综合类 | 46篇 |
预防医学 | 8篇 |
眼科学 | 15篇 |
药学 | 21篇 |
中国医学 | 7篇 |
肿瘤学 | 12篇 |
出版年
2023年 | 6篇 |
2022年 | 21篇 |
2021年 | 12篇 |
2020年 | 18篇 |
2019年 | 14篇 |
2018年 | 13篇 |
2017年 | 10篇 |
2016年 | 17篇 |
2015年 | 28篇 |
2014年 | 25篇 |
2013年 | 25篇 |
2012年 | 23篇 |
2011年 | 30篇 |
2010年 | 20篇 |
2009年 | 32篇 |
2008年 | 37篇 |
2007年 | 29篇 |
2006年 | 23篇 |
2005年 | 20篇 |
2004年 | 20篇 |
2003年 | 18篇 |
2002年 | 14篇 |
2001年 | 12篇 |
2000年 | 12篇 |
1999年 | 10篇 |
1998年 | 19篇 |
1997年 | 12篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 4篇 |
1987年 | 6篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有594条查询结果,搜索用时 31 毫秒
1.
2.
3.
Summary In 13 patients presenting as lethal midline granuloma (LMG), computed tomography proved essential for determining the extent of the disease, guiding biopsy and planning radiotherapy. Magnetic resonance imaging (MRI) was also helpful for the latter, because it could distinguish fluid retained within the paranasal sinuses from solid masses and tumour from granulation tissue; it was of little value for detecting bone lysis. Eight of the 13 patients proved to have T-cell lymphoma, two had Crohn's disease, in one the lesion was factitious and two had granulomas without diagnostic histological features. 相似文献
4.
Fine-needle aspiration cytology of lymph nodes and extranodal swellings in 160 cases showed granulomatous reaction with or without caseation necrosis in 83%. The material was acellular or predominantly composed of necrotic material, polymorphs, and lymphocytes in 17%. The age of the patient ranged from 1.5 to 72 yr. The male to female ratio was 1:1.3. Acid-fast bacilli (AFB) could be demonstrated in 40.6% of cases. In cases associated with cellular reaction and necrosis. AFB positivity was 50.0%, while it was 66.7% in cases with acellular necrotic material. 相似文献
5.
Immunolocalization of extracellular matrix proteins and integrins in sarcoid lymph nodes 总被引:1,自引:0,他引:1
K. Shigehara Noriharu Shijubo Michio Hirasawa Shosaku Abe Toshimitsu Uede 《Virchows Archiv : an international journal of pathology》1998,433(1):55-61
To improve our understanding of the role of extracellular matrix (ECM) proteins and integrins during the processes of granuloma
formation in sarcoidosis, we examined the distribution of ECM proteins and the expression of integrins in sarcoid lymph nodes
by immunohistochemical methods. We also examined the expression of transforming growth factor-β1 (TGF-β1), which is one of
major regulators for synthesis of ECM proteins. Most ECM proteins were detected in the periphery of the granulomas in a concentric
pattern, and fibronectin was diffusely detected from an early to a regressive stage. Compared with normal lymph nodes, most
β1-integrin subfamilies (α1, α4, α5 and α6) were more strongly expressed on lymphocytes around the granulomas. Epithelioid
cells exhibited strong expression of the α5 molecule. Fibroblasts exhibited the expression of the α2 and α5 molecules surrounding
ECM proteins. The α5β1 molecule had a distribution similar to that of fibronectin. TGF-β1 was detected in epithelioid cells
throughout the various evolutional stages and its expression was especially marked in mature granulomas. Interaction of fibronectin
and the α5β1 molecule may have an important role in the process of formation of sarcoid granuloma. The expression of TGF-β1
may be involved in the regression of sarcoid granuloma by initiating fibrosis and atrophy of epithelioid cells.
Received: 2 December 1997 / Accepted: 19 February 1998 相似文献
6.
Bogers JJ Chatterjee S Jacobs W Fallon PG Dunne DW Langermans JA Deelder AM Thomas AW Van Marck EA 《Virchows Archiv : an international journal of pathology》2004,445(3):285-291
Adults and children have differences in their susceptibility to schistosomiasis. Whether this age-dependent innate susceptibility influences parasite-caused granulomogenesis is difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. Hepatic and intestinal granuloma formation was observed in both pre-pubescent and adult monkeys. Two distinct stages of granulomas were discerned, the exudative and the productive stage. In the intestine, more granulomas were generated in the colon than in the ileum. In contrast to the adult animals, the juvenile rhesus monkeys had higher numbers of colonic granulomas, these higher numbers being predominantly of the more advanced productive stage. Juvenile animals had a statistically non-significant increased worm burden. These results suggest that juvenile rhesus monkeys have a significantly more intense and advanced colonic response towards entrapped S. mansoni eggs after primary schistosome infections and, thereby, are more susceptible to parasite infection.Research protocols involving non-human primates received ethical clearance by the Institutional Animal Care and Use Committee of the Biomedical Primate Research Centre (Rijswijk, The Netherlands), according to Dutch Law. 相似文献
7.
Espinet B Solé F Pedro C Garcia M Bellosillo B Salido M Florensa L Camacho FI Baró T Lloreta J Serrano S 《Human pathology》2005,36(11):1232-1237
Mantle cell lymphoma (MCL) is a B-cell neoplasm with a relatively aggressive clinical course. There is a very small subgroup of patients who present with atypical lymphocytes in peripheral blood, with or without lymphocytosis, lymphadenopathy, or splenomegaly, and with an indolent clinical course. They frequently show mutated IgV(H) genes and CD5 negativity. We report an asymptomatic elderly patient who presented with a single submandibular lymphadenopathy. The biopsy showed immunophenotype and t(11;14)(q13;q32) consistent with MCL. The abnormal lymphoid population was also detected in peripheral blood and bone marrow. The patient has remained asymptomatic for 5 years without receiving any therapy. It is uncertain whether these cases represent an early-stage event in the development or an indolent form of MCL. The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions. 相似文献
8.
A case of unilateral histoplasmal "granulomatous" mastitis diagnosed by fine-needle aspiration biopsy (FNAB) is presented. The clinical presentation and mammographic findings were strongly suspicious for carcinoma. FNAB cytology showed a picture of necrotizing granuloma secondary to histoplasmosis. The lesion was treated with surgical excision and appropriate antifungal therapy. The differential diagnosis of granulomatous mastitis is discussed. 相似文献
9.
中耳胆固醇肉芽肿 总被引:5,自引:0,他引:5
目的 探讨中耳胆固醇肉芽肿的病因、发病机制以及治疗方法。方法 回顾性总结分析我院1988年3月~2003年3月经手术和病理证实的70例(耳)中耳胆固醇肉芽肿病人的临床资料。70例(耳)中,术前诊断为胆脂瘤型中耳炎37例,骨疡型中耳炎13例,此二者之中考虑胆固醇肉芽肿者13例;中耳乳突术后感染5例,分泌性中耳炎7例,特发性血鼓室8例,其中考虑可能为胆固醇肉芽肿者2例。所有病人均有不同程度听力下降、耳闭塞感或伴耳鸣,亦可有耳溢液、头痛、头昏及其他症状。70例(耳)均接受手术治疗,依照术前检查,根据病变程度不同而选择不同术式。结果 65例(耳)干耳,随访1年以上无复发。3例(耳)行改良乳突根治加鼓室成形术,术后半年流脓,后改行乳突根治术,术后均干耳;2例(耳)行鼓室探查加鼓窦开放术,术后半年及1年又流脓伴听力下降,后改行改良乳突根治加鼓室成形术,术后干耳。结论 中耳胆固醇肉芽肿的病因主要有:含气腔通气受阻、引流障碍及含气腔出血。中耳胆固醇肉芽肿与特发性血鼓室、分泌性中耳炎及胆脂瘤关系密切。术式的选择应根据病变范围和程度来决定,其原则是彻底清除病变,保持通畅引流。 相似文献
10.
分枝杆菌肉芽肿形成的细胞及分子机制究进展 总被引:1,自引:0,他引:1
分枝杆菌肉芽肿是由细菌与不同的宿主细胞如巨噬细胞、树突细胞、淋巴细胞等相互作用,在各种免疫分子如细胞因子、黏附分子、补体等参与下,形成的特征性病理学结构.其形成过程中细菌各种成分、宿主不同细胞、产生的不同免疫分子均起重要作用.而斑马鱼模型的建立及原位荧光观察方法的应用亦为分枝杆菌尤其是海鱼分枝杆菌感染肉芽肿的体内形成及演变研究提供基础. 相似文献