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Michihiro Hide Takamasa Suzuki Ayaka Tanaka Hiroshi Aoki 《Allergology international》2019,68(1):59-67
Background
Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003. However, its efficacy and safety in Japanese patients with chronic spontaneous urticaria (CSU) are unknown.Methods
We conducted a prospective, multicenter, randomized, placebo-controlled, double-blind study in adolescent and adult CSU outpatients aged 12 to < 65 years (JAPIC-CTI No. 152786). Overall, 94, 91, and 92 eligible patients orally received placebo, rupatadine 10 mg, and 20 mg once daily for 2 weeks, respectively. The primary endpoint was change from baseline to the second week of treatment in total pruritus score (TPS, sum of daytime and nighttime pruritus scores).Results
The results yielded a least squares mean TPS difference of ?1.956 between rupatadine 10 mg versus placebo, and ?2.121 between rupatadine 20 mg versus placebo (analysis of covariance, both P < 0.001). The incidence of adverse events was 8.5% for placebo, 20.9% for rupatadine 10 mg, and 17.4% for rupatadine 20 mg. Somnolence was the only adverse drug reaction to rupatadine reported in 2 or more subjects. No serious or clinically significant adverse events were observed.Conclusions
The primary and secondary efficacy endpoints consistently favored rupatadine 10 and 20 mg doses over the placebo. No noteworthy dose-related increase in the incidence of adverse drug reactions was observed. Rupatadine is safe and effective at a dose of 10 mg once daily, and can be safely increased to 20 mg once daily, as necessary. 相似文献2.
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Georgs Andrejevs Julio E. Celis Guido Guidi Alojz Peterle Richard Sullivan Roger Wilson 《Molecular oncology》2009,3(1):18-23
The objective of the workshop was to examine what Cancer Innovation in Europe means and what it should be standing for in the future. The panel discussion brought together patients, researchers, politicians and industry in order to examine what cancer innovation represents to them, what the challenges are to innovation, and how innovation in this research area can be encouraged and developed in the EU. 相似文献
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《Addiction Research & Theory》2013,21(6):469-478
In Sweden, prohibitionist drug policy has contributed to making cannabis an illegal drug, viewed as dangerous, while alcohol is considered a legitimate recreational commodity. But the official Swedish cannabis discourse is now being contested on internet. In virtual environments an often employed way to try to legitimize cannabis use is by comparing it to alcohol. This indicates the importance of analyzing how substances are attributed with meaning in various contexts. This study aims to describe and analyze the discursive role of alcohol in Swedish online discussions of cannabis use and policy. Approximately 700 alcohol-related comments, posted during one year period, were retrieved from the cannabis-section of Swedish Flashback Forum (a website open for public viewing). The sample was analyzed qualitatively with analytical tools such as nodal points, analogies, distinctions and typological examples. Two concepts, danger and discrimination, were identified as nodal points in a cannabis legalization discourse, and provided a backdrop from which comparisons between alcohol and cannabis were made meaningful. We have found that cannabis and alcohol “changed places” in these online discussions. The participants drew on a prohibitionist cannabis discourse but applied its arguments to alcohol; alcohol was thereby given the role of the “ideal enemy” while cannabis was presented as a harmless plant rejected by society on moral rather than scientific grounds. The relevance of acknowledging and reflecting upon the influence that online “talk” has on young people's attitudes towards drugs is discussed. 相似文献
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