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登革病毒(DV)属于黄病毒属,分为4 个血清型,是具有包膜的单股正链RNA病毒。DV可通过埃及伊蚊和白纹伊蚊传播,引起登革热和登革出血热/登革休克综合征。该病广泛流行于热带和亚热带地区,是一种危害较大的传染病。DV感染机理尚不十分清楚,靶细胞上DV特异性受体的研究是近几年关注的热点,目前认为DV受体包括糖胺聚糖(GAGs)、硫酸乙酰肝素(HS)、与脂多糖连接的CD14相关分子等。现就DV受体的研究进展作一综述。 相似文献
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通过对我院收治的30例舒张性心衰(DiastolicHeartFailure,DHF)患者的护理干预情况进行回顾性分析,包括心理护理、饮食护理、用药等方面的护理干预。发现DHF患者对硝酸甘油注射液,利尿剂等治疗药物反应敏感,在整个护理过程中,护理人员需密切观察心率、心律和血压变化及尿量和体重等改变情况,以调整药物剂量和输入速度,并及早发现患者血输出量不足的症状及其他并发症,同时做好心理护理和基础护理工作,可提高治疗成功率,对患者的康复有重要作用。 相似文献
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Objective
This study aims to determine the effectiveness of health education through audiovisual media on improving family knowledge in the prevention of dengue fever (DHF).Method
This study used a Quasi Experiment research design with a research design of Non-Equivalent Control Group. The study was conducted in the community with a sample of 40 people, consisting of 20 for experimental group and 20 for control group. The samples were selected using purposive sample collection method. The measuring instrument used is a questionnaire that has been tested for validity and reliability. The analysis was done through univariate analysis and bivariate analysis using t-independent test.Result
This study found that the showed a significant increase in changes in the level of attitudes and actions of families in the prevention of dengue fever by using audiovisual media, (p = 0.000), (p = 0.000).Conclusion
It is recommended that the health workers should provide health education by using audiovisual media in the prevention of dengue fever. 相似文献7.
Dengue virus (DENV) NS1 is a versatile non-structural glycoprotein that is secreted as a hexamer, binds to the cell surface of infected and uninfected cells, and has immune evasive functions. DENV NS1 displays two conserved N-linked glycans at N130 and N207. In this study, we examined the role of these two N-linked glycans on NS1 secretion, stability, and function. Because some groups have reported reduced yields of infectious DENV when N130 and N207 are changed, we analyzed glycosylation-deficient NS1 phenotypes using a transgenic expression system. We show that the N-linked glycan at position 130 is required for stabilization of the secreted hexamer whereas the N-linked glycan at residue 207 facilitates secretion and extracellular protein stability. Moreover, NS1 mutants lacking an N-linked glycan at N130 did not interact efficiently with complement components C1s and C4. In summary, our results elucidate the contribution of N-linked glycosylation to the function of DENV NS1. 相似文献
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目的 为控制我市流行性出血热的流行。方法 领导重视,采取一系列综合干预措施,开展健康教育、举办知识讲座培训班,发动群众灭鼠,积极开展EHF疫苗的免疫接种。结果 通过知识培训,EHF防制知识回答正确率提高了49.2%。EHF疫苗的接种人数比干预前提高了许多倍。EHF发病率与去年同期相比下降了34.2%。结论 结合干预措施效果显。但今后健康教育任务仍十分艰巨。 相似文献
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Ka Tik Cheung Daniel Man-yuen Sze Kwok Hung Chan Polly Hang-mei Leung 《Immunobiology》2018,223(4-5):356-364
Caspase-4 physically interacts with caspase-1 and is believed to be a proinflammatory caspase that can induce the inflammatory form of programmed cell death (pyroptosis) and the release of mature interleukin (IL)-1β. However, the function of caspase-4 in dengue virus infection is not yet fully understood. We examined the function of caspase-4 in IL-1β production and pyroptosis during dengue virus serotype-2 (DENV-2) infection in human macrophages. In this study, DENV-2 infection increased IL-1β protein level with activated caspase-4 activity. Using primary macrophages, we observed that caspase-4 induces activation of caspase-1 and secretion of IL-1β in response to DENV-2 infection, without the need for secondary signals to stimulate the assembly of the inflammasome. These findings indicate that the regulation of caspase-1 activity by capsase-4 could represent a unique mechanism. Our data suggest that caspase-4 is upstream of caspase-1 in the pathway that regulates pyroptosis and IL-1β synthesis in macrophages during DENV-2 infection. 相似文献