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排序方式: 共有1296条查询结果,搜索用时 15 毫秒
1.
Andy KH Lim 《World journal of gastroenterology : WJG》2020,26(10):1020-1028
Rhabdomyolysis is a syndrome of skeletal muscle injury with release of cellular constituents such as potassium,phosphate,urate and intracellular proteins such as myoglobin into the circulation,which may cause complications including acute kidney injury,electrolyte disturbance and cardiac instability.Abnormal liver function tests are frequently observed in cases of severe rhabdomyolysis.Typically,there is an increase in serum aminotransferases,namely aspartate aminotransferase and alanine aminotransferase.This raises the question of liver injury and often triggers a pathway of investigation which may lead to a liver biopsy.However,muscle can also be a source of the increased aminotransferase activity.This review discusses the dilemma of finding abnormal liver function tests in the setting of muscle injury and the potential implications of such an association.It delves into some of the clinical and experimental evidence for correlating muscle injury to raised aminotransferases,and discusses pathophysiological mechanisms such as oxidative stress which may cause actual liver injury.Serum aminotransferases lack tissue specificity to allow clinicians to distinguish primary liver injury from muscle injury.This review also explores potential approaches to improve the accuracy of our diagnostic tools,so that excessive or unnecessary liver investigations can be avoided. 相似文献
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肠梗阻是临床常见的急腹症,绞窄性肠梗阻的死亡率可高达45%~30%,我们自1995年8月至1997年4月共收治肠梗阻53例,其中单纯性肠梗阻28例,经手术证实为绞窄性肠梗阻25例(其中肠坏死8例),在治疗前均测定血清磷、肌酸激酶及其同工酶,其结果:本组病例中血清磷升高者14例,其中以8例肠坏死为显著,肌酸激酶及其同功酶的升高也以绞窄性肠梗阻为明显,其中又以发病时间在48小时以内者和8例肠坏死者为著,因此,我们认为:血清磷、肌酸激酶及其同工酶的测定可以作为判断肠管是否发生绞窄及坏死的辅助诊断指标 相似文献
4.
Hisashi Tanii Norio Taniguchi Hisayoshi Niigawa Takayoshi Hosono Yasumitsu Ikura Sakae Sakamoto Takashi Kudo Tsuyoshi Nishimura Masatoshi Takeda 《Brain research》1996,743(1-2)
The neuroleptic malignant syndrome (NMS) is a life-threatening complication of neuroleptic treatment. To elucidate the pathogenesis of NMS, an animal model has been developed. Experimental rabbits treated with haloperidol (1 mg/kg) by intramuscular injection, were studied for the diagnostic symptoms of increased muscle rigidity, elevated body temperature, and high serum creatine phosphokinase (CPK) level. Administration of haloperidol (1 mg/kg) and atropine (0.4 mg/kg), and exposure to high ambient temperature (35°C) induced a significant increase in electromyographic activity with muscle rigidity similar to that observed in patients with NMS. Such rabbits also showed elevated body temperature and serum CPK value. In addition to the similarity of the signs and symptoms, all parameters measured (muscle rigidity, body temperature, and serum CPK level) were normalized by dantrolene treatment. The effectiveness of dantrolene in the experimental animal partially confirms the validity of this animal model for NMS. This experimental animal model for NMS may be useful to elucidate the pathogenesis of NMS. 相似文献
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乌司他丁对严重烧伤患者伤后早期心肌损害的防治作用 总被引:15,自引:2,他引:13
目的观察乌司他丁(UTI)对烧伤“休克心”的防治作用,探讨其可能的机制。方法选择笔者单位收治的伤后24h内入院、烧伤面积〉50%TBsA的34例特重度烧伤患者,分为烧伤组和UTI治疗组,每组17例。两组患者均进行常规治疗,且UTI治疗组患者入院后立即给予UTI10万U静脉滴注,3次/d,连续7d。于两组患者伤后2、4、7d采血,检测其血浆中性粒细胞弹性蛋白酶(PMN elastase)、心肌肌钙蛋白I(cTnI)含量和心肌型肌酸激酶同工酶(CK—MB)活性,以公认的各指标正常值作参考,并对3项指标进行相关性分析。结果(1)伤后2、4、7d,两组患者血浆PMN elastase及cTnI含量均显著高于正常值(P〈0.01);UTI治疗组与烧伤组比较,两指标偏低。(2)与正常值比较,伤后2、4、7d烧伤组患者CK—MB活性明显升高(P〈0.01),第4天达高峰;UTI治疗组伤后2、4d CK—MB活性明显高于正常值(P〈0.05或0.01),但与烧伤组比较升幅较小,第7天降至正常值水平(P〉0.05)。(3)34例烧伤患者PMN elastase、cTnI含量及CK—MB活性三者间均呈现显著正相关,前两者的相关系数为0.904,后两者的相关系数为0.922,PMN elastase含量与CK-MB活性的相关系数为0.829(均为P〈0.01)。结论UTI能够显著减轻严重烧伤患者心肌损害的程度,有效抑制PMN elastase的过度释放。 相似文献
7.
Activities of creatine kinase isoenzymes in single skeletal muscle fibres of trained and untrained rats 总被引:1,自引:0,他引:1
Katsumasa Yamashita Toshitada Yoshioka 《Pflügers Archiv : European journal of physiology》1992,421(2-3):270-273
Biochemical changes in the creatine kinase isoenzyme compositions in single muscle fibres of different types in rats were induced by endurance running training. Single muscle fibres were dissected from the soleus and extensor digitorum longus muscles of Wistarstrain male rats trained on a motor-driven treadmill for 16 weeks. Each fibre was typed histochemically (SO, slow-twitch oxidative; FOG, fast-twitch oxidative glycolytic; FG, fast-twitch glycolytic), and the activities of total creatine kinase and its four isoenzymes (CK-MM, -MB,-BB, and mitochondrial creatine kinase) were measured. The endurance training did not affect the total creatine kinase activity, but resulted in significantly increased activities of CK-MB and CK-BB in SO and FOG fibres, and the mitochondrial enzyme activity in FOG and FG fibres. Endurance training induced biochemical changes in the isoenzyme compositions, specifically in FOG fibres. These results suggest that changes in creatine kinase isoenzymes with endurance training reflect changes in the energy metabolism in the different muscle fibres, supporting the hypothesis that the different isoenzymes play different roles in energy transduction. 相似文献
8.
目的 为了探讨肾脏疾病患者血浆内皮素水平与肾脏疾病病情程度的关系,为肾脏疾病治疗效果的评价提供依据.方法 采用放射免疫分析(RIA)观察了77例肾脏疾病患者治疗前后血浆内皮素水平的动态变化,并与60例正常对照组比较.结果 正常对照组血浆内皮素浓度为43.1±15.2ng/L,肾脏疾病患者治疗前血浆内皮素水平为161±83.8ng/L,治疗后为97.4±52.7ng/L,均高于正常对照组(P值均<0.001).肾脏疾病治疗后内皮素水平明显下降(P<0.001),与BUN,Cr水平的下降具有一定的相关性(相关系过分别为0.54,0.55).结论血浆内皮素水平随着肾脏疾病严重程度的增加而升高,血浆内皮素水平可作为肾脏疾病治疗效果评定的指标之一 相似文献
9.
Cleide G. da Silva Ana Rúbia F. Bueno Patrícia F. Schuck Guilhian Leipnitz Csar A. J. Ribeiro Clvis M. D. Wannmacher Angela T. S. Wyse Moacir Wajner 《International journal of developmental neuroscience》2003,21(4):217-224
L-2-Hydroxyglutaric acid (LGA) is the biochemical hallmark of patients affected by the neurometabolic disorder known as L-2-hydroxyglutaric aciduria (LHGA). Although this disorder is predominantly characterized by severe neurological findings and pronounced cerebellum atrophy, the neurotoxic mechanisms of brain injury are virtually unknown. In the present study, we investigated the effect of LGA, at 0.25-5mM concentrations, on total creatine kinase (tCK) activity from cerebellum, cerebral cortex, cardiac muscle and skeletal muscle homogenates of 30-day-old Wistar rats. CK activity was measured also in the cytosolic (Cy-CK) and mitochondrial (Mi-CK) fractions from cerebellum. We verified that tCK activity was significantly inhibited by LGA in the cerebellum, but not in cerebral cortex, cardiac muscle and skeletal muscle. Furthermore, CK activity from the mitochondrial fraction was inhibited by LGA, whereas that from the cytosolic fraction of cerebellum was not affected by the acid. Kinetic studies revealed that the inhibitory effect of LGA on Mi-CK was non-competitive in relation to phosphocreatine. Finally, we verified that the inhibitory effect of LGA on tCK was fully prevented by pre-incubation of the homogenates with reduced glutathione (GSH), suggesting that this inhibition is possibly mediated by oxidation of essential thiol groups of the enzyme. Considering the importance of creatine kinase activity for energy homeostasis, our results suggest that the selective inhibition of this enzyme activity by increased levels of LGA could be possibly related to the cerebellar degeneration characteristically found in patients affected by L-2-hydroxyglutaric aciduria. 相似文献
10.
Priscilla M. Clarkson Paul Litchfield James Graves John Kirwan William C. Byrnes 《European journal of applied physiology》1985,53(4):368-371
Summary The purpose of this study was to 1) compare serum creatine kinase (CK) activity following two forearm flexion isometric exercise regimens differing in work to rest ratio, and 2) examine the CK response to a repeated bout of isometric exercise. Eleven males were tested on two sessions (bouts) spaced 1 week apart. For bout 1, five subjects (group A) performed a forearm flexion isometric exercise consisting of 40 10-s maximal contractions with 20-s inter-trial rests (1020), while six (group B) performed 40 maximal 10-s contractions with 5-s inter-trial rests (105). The increase in serum CK activity following the 1020 exercise (143%) was significantly greater than that following the 105 exercise (52%). The 1020 exercise was also associated with greater tension generation over trials. One week later, both groups performed a bout of 1020 exercise. A substantial reduction in the serum CK response was found following this second bout. The data suggest that for bout 1 the isometric exercise associated with the greater overall tension levels resulted in the greater CK response. However, when the 1020 exercise was repeated 1 week later, a substantial reduction in the CK response was found which was unrelated to the tension generated.This study was supported by a University Faculty Research Grant No. 2-03021 相似文献