温阳活血利水法对冠心病心衰心功能Ⅲ级以上患者LVEF及BNP的影响

目的评价以温阳活血利水法为组方的中药对冠心病心衰心功能DI级以上患者左心射血分数(LVEF)及脑钠肽(BNP)的影响。方法选取2016年10月-2018年12月辽阳市中医院心内科住院的冠心病心衰、心功能Ⅲ-Ⅳ级患者120例,按照随机数字表法,随机分为治疗组和对照组,每组60例;治疗组给予西医常规治疗加温阳活血利水法组方中药,对照组给予西医常规治疗;疗程28 d观察两组患者治疗前后的中医证候积分、心衰积分、左室射血分数(LVEF)、脑钠肽(BNP)、6min步行距离及患者治疗后12个月的再住院率和病死率。结果治疗后两组患者中医证候积分、心衰积分、LVEF、BNP、6min步行距离均较治疗前显著改善,且治疗组改善更明显,差异有统计学意义(P<0.05);治疗12个月后,治疗组患者的病死率明显低于对照组(P<0.05)。结论在西医规范治疗基础上加用溫阳活血利水法组方中药,可以显著改善心衰患者的心功能,极大提高患者生活质量。     

Circular RNAs 0064286 and 0000475: Potential Diagnostic Biomarkers in Hepatocellular Carcinoma

Objective: Hepatocellular carcinoma (HCC) is considered the highest recorded malignancy in Egypt. The shortage of appropriate biomarkers for early detection often results in the late diagnosis of the HCC. Circular RNAs (CircRNAs) are presented as long stranded non-coding RNA that combine covalently to make a sealed circular form which make them very stable. CircRNAs are known to have interpretative role in cancer development and metastasis. Aim: To examine the dysregulation of two new CircRNAs obtained from Circbase database (hsa_circ_0064286 and hsa_circ_0000475) in the serum of HCC patients as predictable diagnostic biomarkers of HCC and their correlation with some liver biochemical parameters. Methods: Sixty clinically diagnosed HCC Egyptian patients and 25 healthy volunteers were enrolled in the study. Expression levels of the selected CircRNAs was evaluated in subjects’ serum. Moreover, correlation with liver biochemical parameters, sensitivity, and specificity of studied CircRNAs were estimated. Results: Both circular RNAs were significantly down regulated in HCC patients, which was negatively correlated with ALP, ALT, AST, AFP, and bilirubin levels. Circ_0064286 showed more sensitivity and specificity (88.3% and 96%, respectively). Conclusion: As far as we know, this is the first study that shed light on the expression levels of both circRNAs in Egyptian HCC patients. They may serve as potential biomarkers for HCC diagnosis. Moreover, those circRNAs draw attention as therapeutic targets for HCC through targeting their sponge miRNAs.