Assessing graduate programs for healthcare information management/technology (HIM/T) executives

This paper describes a methodology to assess health/medical informatics graduate-level education curricula. The authors used the Certified Professional in Healthcare Information Management Systems (CPHIMS) exam objectives published by the Healthcare Information and Management Systems Society (HIMSS) as the basis for their assessment. The authors compared the 69 CPHIMS exam objectives against four health/medical informatics program course objectives as stated in the selected program's online graduate catalog. Results showed that the two programs with management as a focus addressed the majority (67 and 59%) of the CPHIMS objectives within core and elective courses combined. Overall, the other two programs addressed closer to a third of the CPHIMS objectives (36 and 32%). This methodology could prove to be useful in assisting students interested in graduate-level training programs with a tool by which to measure the congruence of the curricula of different programs with the mission of the programs and with their own professional interests.     

浅谈医院设立首席信息技术主管的必要性

针对医院信息化工作的进展,提出设立首席信息技术主管（CIO）的必要性,明确了CIO在医院信息系统建设和管理中的作用,指出CIO不但要负责信息网络平台的技术支持,还应行使对医院信息的组织管理职能。医院应重视信息系统的开发和利用,重视CIO的作用。CIO也应努力提高自身的水平,成为具有医学、管理、计算机等跨学科的复合型人才。     

医院信息化过程如何选择专业咨询公司

国内医院信息化过程已经进入了一个新的阶段,专业信息化咨询参与医院信息化建设的模式逐渐被大家接受.但是,由于这种商业模式在国内前人还鲜有案例参照,尤其在工作的第一步如何选择合作的的咨询公司上,众多医院信息中心主管还存在疑惑.本文作者通过自身在国外实际医院信息化工作经验,结合咨询公司工作特点,给医院CIO出了一个可参照的工作方法,提出了一些需要注意的问题.     

我国医院信息主管的窘境与出路

我国医院信息化建设还属初级阶段,一些医院信息机构尚处在"边缘化"状态;医院CIO并不能进入医院管理核心层,无法真正参与战略规划和全面推动医院信息化进程;医院CIO未能实现应有的权力价值,并缺乏清晰的升迁路径,进而导致心态失衡.我国医院CIO生存环境的改善和事业的发展,一方面取决于医院信息化建设的水平、医院CIO体制的建立、医学信息学教育与培训;另一方面更取决于医院信息管理者在推动医院信息化进程中做出的贡献.     

高校引入CIO的构想

阐明高校引入CIO体制的必要性，对高校CIO应具备的素质和主要职责做深入的探讨。     

Genetic and biochemical studies on the activation and cytotoxic mechanism of bredinin, a potent inhibitor of purine biosynthesis in mammalian cells

To study the activation and cytotoxic mechanism of bredinin (4-carbamoyl-1-beta-D-ribofuranosylimidazolium-5-olate), a novel nucleoside antibiotic with potent cytotoxic and immunosuppressive effects, we isolated in a single-step manner five mutants resistant to 10 microM bredinin from cultured mouse mammary carcinoma FM3A cells mutagenized with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Such resistant (Brdr) mutants were 15- to 19-fold less sensitive to the antibiotic than wild-type cells and maintained stably their resistant phenotypes in the absence of bredinin for more than 3 months. They were cross-resistant to tubercidin, an adenosine analog. Like wild-type cells, Brdr mutants were capable of incorporating radioactivity from ring-labeled adenosine into the acid-insoluble macromolecular fraction. However, hypoxanthine-guanine phosphoribosyltransferase-deficient (HGPRT-) mutants derived from the Brdr cells did not incorporate the radioactivity at all or at a markedly reduced rate, indicating that blockade of the pathway via adenosine deaminase present in the Brdr cells resulted in loss of their ability to utilize adenosine. Enzyme assays using cell-free extracts revealed that all the Brdr mutants had less than 3% of the adenosine kinase (AK) activity found in wild-type cells. These results demonstrate that the bredinin resistance is attributed to a defective AK activity and, therefore, that bredinin is metabolized by AK, which may phosphorylate it to a toxic nucleotide, bredinin 5'-monophosphate (Brd-MP), in sensitive cells. Among exogenously added purine bases, guanine was able to reverse the cytotoxic effect of bredinin on both wild-type cells and F5 cells carrying the vector pSV2-Escherichia coli xanthine-guanine phosphoribosyltransferase (XGPRT) gene, while xanthine was able to do so only in F5 cells because the base was metabolized to XMP by the cells. These results support the mechanism of bredinin cytotoxicity, that Brd-MP formed in sensitive cells exposed to the antibiotic blocks the conversion of IMP to XMP by inhibiting IMP dehydrogenase.     

消毒剂二氧化氯的毒性效应研究

按照消毒技术规范操作程序，对二氧化氯的刺激性．一般毒性和致突变作用进行了试验 观察。结果显示：该消毒剂的最大应用浓度对眼粘膜有一定的刺激性，毒性分级属中等毒性，但在体 内蓄积性极低并可产生耐受性，致突变试验结果也为阴性反应。提示该消毒剂的正常使用是安全 的。     

Risedronate,a novel pyridinyl bisphosphonate for the treatment of osteoporosis and Paget’s disease of bone

Osteoporosis and Paget’s disease of bone are the most common metabolic bone diseases. They cause considerable disability and pain, and reduce quality of life. The elderly are at greatest risk of osteoporotic fractures, and in an ageing world population, the burden of the disease is likely to increase. Bisphosphonates are known to be effective antiresorptive agents for the treatment of Paget’s disease of bone, postmenopausal osteoporosis (PMO) and corticosteroid-induced osteoporosis (CIO). However, some bisphosphonates have been associated with troublesome gastrointestinal side-effects. Risedronate is a novel pyridinyl bisphosphonate recently approved in the USA for the treatment of Paget’s disease, and is under development for the treatment of PMO and CIO. Risedronate is effective and well-tolerated in the treatment of Paget’s disease. It has the shortest treatment regimen of any oral bisphosphonate; a two month course of therapy results in sustained remission, as determined by biochemical indices. The results of recent clinical trials suggest that risedronate is also an effective, well-tolerated therapy for PMO and CIO. Risedronate represents an advance in the therapeutic options available for the treatment of Paget’s disease, and is expected to be of further value for treatment of PMO and CIO when it receives approval for use in these conditions.     

The cancer information overload (CIO) scale: Establishing predictive and discriminant validity

Objective

Survey data suggests that approximately three-fourths of adults are overwhelmed by cancer information – a construct we label cancer information overload (CIO). A significant limitation of existing research is that it relies on a single-item measure. The objective of the current study is to develop and validate a multi-item measure of CIO.

Methods

Study 1 (N = 209) surveyed healthcare and manufacturing employees at eight worksites. Colonoscopy insurance claims data were culled eighteen months later to evaluate the predictive validity of CIO. Study 2 (N = 399) surveyed adults at seven shopping malls. CIO and cancer fatalism were measured to examine the properties of the two constructs.

Results

Study 1 identified a reliable 8-item CIO scale that significantly predicted colonoscopy insurance claims 18 months after the initial survey. Study 2 confirmed the factor structure identified in Study 1, and demonstrated that CIO, cancer fatalism about prevention, and cancer fatalism about treatment are best modeled as three distinct constructs.

Conclusion

The perception that there are too many recommendations about cancer prevention to know which ones to follow is an indicator of CIO, a widespread disposition that predicts colon cancer screening and is related to, but distinct from, cancer fatalism.

Practice implications

Many adults exhibit high CIO, a disposition that undermines health efforts. Communication strategies that mitigate CIO are a priority. In the short-term, health care providers and public health professionals should monitor the amount of information provided to patients and the public.     

高校数字校园管理模式探讨

针对目前高校数字校园管理较乱的状况,充分考虑到教育信息化、数字化发展的要求,并根据数字校园的具体特点,提出了在CIO领导下,以教育技术处为主要职能机构的管理模式。