补充适量精氨酸加速大鼠烧伤创面愈合

目的 探讨精氨酸对烧伤创面愈合的影响和量效关系。方法 通过大鼠深Ⅱ度烫伤模型,补充不同剂量精氨酸,记录伤前,伤后体重,测定烧伤创面面积Ⅰ,Ⅲ型胶原比例,羟脯氨酸含量和真皮细胞增殖周期。结果 补充适量精氨酸可增加烧伤创面中ＯＨＰ含量,降低烧伤创面Ⅰ：Ⅲ型胶原比例,加速真皮细胞ＤＮＡ复制,增加伤后大鼠体重。     

白内障大鼠晶体和房水中牛磺酸及4种氨基酸的测定

目的：观察半乳糖性白内障大鼠房水及晶体中牛磺酸(Tau)及谷氨酸(Glu)、甘氨酸(Gly)、赖氨酸(Lys)、色氨酸(Try)4种氨基酸含量变化情况。方法：应用高效液相色谱仪(HPLC)，测定不同组别Wistar大鼠房水及晶体中上述物质含量。结果：正常大鼠房水及晶体中上述物质含量随着大鼠日龄的延长而逐渐增加，而半乳糖性白内障大鼠这5种物质的含量与同期正常组大鼠房水及晶体中这5种物质含量相比明显下降。结论：半乳糖性白内障房水及晶体中牛磺酸及4种氨基酸的改变与白内障疾病的发生、发展有密切联系。     

Growth,free plasma and muscle amino-acids in uraemic rats fed various low-protein diets

The nutritional effects of low-protein diets are difficult to assess in humans. Normal and uraemic growing rats were therefore fed: a moderately low-protein (12%) reference diet (diet R), two 5% casein diets, one supplemented with essential amino acids (AA) (diet A) and the other with their keto acids (diet K), and a 7% casein diet isonitrogenous with diet K (diet L). Appetite and growth of both uraemic and control rats were identical on diets R and A and were reduced on diets K and L. Stunting was prominent in rats fed diet L and more severe than in those on diet K. Diet K induced marked anorexia in controls. This effect was smaller in uraemic rats, which were all anorectic, regardless of the diet. Plasma essential AA were similar in rats on diets R and A but low in control rats fed diets L and K. In particular, diet K did not improve the branchedchain AA levels although it produced better growth than diet L. Plasma and muscle threonine were surprisingly elevated in rats on the semi-synthetic diets A and K, despite identical or lower consumptions. Regardless of the diet, uraemia resulted in unchanged or increased plasma essential AA, despite reduced appetite and stunting. Uraemia caused a marked rise in some non-essential AA. Muscle essential AA, except for threonine, were essentially unaltered and did not correlate with growth or uraemia.