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排序方式: 共有71条查询结果,搜索用时 15 毫秒
1.
Bang LE Ripa RS Grande P Kastrup J Clemmensen PM Wagner GS 《Journal of electrocardiology》2008,41(6):609-613
Introduction
Magnetic resonance imaging using the delayed contrast-enhanced (DE-MRI) method can be used for characterizing and quantifying myocardial infarction (MI). Electrocardiogram (ECG) score after the acute phase of MI can be used to estimate the portion of left ventricular myocardium that has infracted. There are no comparison of serial changes on ECG and DE-MRI measuring infarct size.Aim
The general aim of this study was to describe the acute, healing, and chronic phases of the changes in infarct size estimated by the ECG and DE-MRI. The specific aim was to compare estimates of the Selvester QRS scoring system and DE-MRI to identify the difference between the extent of left ventricle occupied by infarction in the acute and chronic phases.Methods
In 31 patients (26 men, age 56 ± 9) with reperfused ST-elevation MI (11 anterior, 20 inferior), standard 12-lead ECG and DE-MRI were taken from 1 to 2 days (acute), 1 month (healing), and 6 months (chronic) after the MI. Selvester QRS scoring was used to estimate the infarct size from the ECG.Results
The correlation values between infarct size measured by DE-MRI and QRS scoring range from 0.33 to 0.43 higher for anterior than inferior infarcts. The infarct size estimated by QRS scoring was larger (about 5% of the left ventricle) than infarct size by DE-MRI acute and 1 month, but at 6 months, there was no difference. In about half of the patients, the QRS score agreed with DE-MRI in change of infarct size from acute to 6 months.Conclusion
In conclusion, the Selvester QRS scoring system is in half of the patients with reperfused first time MI in good accordance with DE-MRI in identifying a decrease or no change in the extent of left ventricle occupied by infarction in the acute and chronic phases. 相似文献2.
Thomas F. Spiegel Travis B. Wassermann Natalie Neumann Mitchell J. Coplan Kirk T. Spencer Daniel Adelman Rupa Mehta Sanghani Corey E. Tabit 《The American journal of emergency medicine》2018,36(7):1202-1208
Background
A multidisciplinary team at a major academic medical center established an Acutely Decompensated Heart Failure Clinical Pathway (ADHFCP) program to reduce inpatient readmission rates among patients with heart failure which, among several interventions, included an immediate consultation from a cardiologist familiar with an ADHFCP patient when the patient presented at the Emergency Department (ED). This study analyzed how that program impacted utilization of services in the ED and its subsequent effect on rates of admission from the ED and on disposition times.Methods
ADHFCP inpatient visits were retrospectively risk stratified and matched with non-program inpatient visits to create a control group. A Cox survival model analyzed the ADHFCP's impact on patients' likelihood to visit the ED. Multivariable ANOVA evaluated the impact of the program on the patients' likelihood of being admitted when presenting at the ED. The ADHFCP's impact on bed-to-disposition time in the ED was evaluated by Wilcoxon's rank-sum test, as were doses of diuretics administered in the ED.Results
The survival analysis showed no impact of the ADHFCP on patients' likelihood of visiting the ED, but ADHFCP patients presenting to the ED were 13.1 (95% CI: 3.6–22.6) percentage points less likely to be admitted. There was no difference in bed-to-disposition times, but ADHFCP patients received diuretics more frequently and at higher doses.Conclusions
Improved communication between cardiologists and ED physicians through the establishment of an explicit pathway to coordinate the care of heart failure patients may decrease that population's likelihood of admission without increasing ED disposition times. 相似文献3.
Tanaka K Shirakawa H Okada K Konno M Nakagawa T Serikawa T Kaneko S 《Neuroscience letters》2007,426(2):75-80
The ataxic groggy rat (strain name; GRY) is an autosomal recessive neurological mutant found in a closed colony of Slc:Wistar rats. Recent genetic analysis has identified the missense (M251K) mutation in the alpha(1) subunit of the Ca(V)2.1 (P/Q-type) voltage-dependent Ca(2+) channel gene (Cacna1a) of GRY rat. In this study, we found that high-voltage-activated (HVA) Ca(2+) channel currents in acutely dissociated Purkinje cells of GRY rats showed increased (not decreased) current density and depolarizing shift of the activation and inactivation curves compared with those of normal Wistar rats. In contrast low-voltage-activated (LVA) Ca(2+) channel currents of GRY rats showed no significant changes. These results suggest that functional alteration of Ca(2+) channel currents in cerebellar Purkinje cells of GRY rats is attributed to the change of HVA Ca(2+) channel currents, and that increased HVA Ca(2+) channel function underlies the cerebellar dysfunction and ataxic phenotype of GRY rats. 相似文献
4.
5.
Neil Jain Bipin Theruvil Nigel Trimmings 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2009,19(1):55-57
A 63-year-old woman presented with a 3-week history of worsening right knee pain. She was fully unable to bear weight and
denied any history of trauma, locking or giving way. On examination, she was systemically well with posterolateral joint line
tenderness and a reduced range of movement. Blood tests and a joint aspirate were normal. Radiographs reported no fracture,
but suggested a loose body in the lateral gutter of the knee. She was discharged with analgesia and physiotherapy. Subsequent
follow-up X-rays demonstrated the opacity in the later gutter to be appearing less dense until it eventually disappeared.
This correlated to a progressive improvement in the patient’s pain and range of movement in the knee leading to the diagnosis
of acute calcific tendinitis of the popliteus tendon. This case report suggests that calcifying tendinitis of popliteus tendon
should be considered in the differential diagnosis of acutely painful knee. The case demonstrates that the natural history
of calcifying tendinitis of popliteus is similar to that in supraspinatus and that conservative treatment will eventually
resolve the symptoms. 相似文献
6.
The therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) has recently been explored in various pathological conditions of the central nervous system (CNS). However, the application of BM-MSCs in acutely induced Alzheimer's disease (AD) has not yet been reported. Herein the feasibility of using the BM-MSCs, as a therapeutic agent for AD has been tested. To assess this possibility, an acutely induced AD model induced by injecting amyloid-β (Aβ) into the dentate gyrus (DG) of hippocampus of C57BL/6 mice was used. Intracerebral transplantation of BM-MSCs into the brain of an induced AD model reduced their Aβ levels when compared to sham-transplanted animals. The diminution of Aβ deposits was accompanied by the activation of microglia. In addition, the activated microglia was located near the Aβ deposits, and their morphology was changed from ramified to ameboid as a sign of microglial phagocytosis. This study provides evidence that BM-MSCs can promote the reduction of Aβ through the microglial activation in this acutely induced AD brain, suggesting a potential therapeutic agent against AD. 相似文献
7.
Giuseppina Martella Paola Bonsi Giuseppe Sciamanna Paola Platania Graziella Madeo Annalisa Tassone Dario Cuomo Antonio Pisani 《Epilepsia》2009,50(4):702-710
Purpose: We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays. Methods: Combined electrophysiologic and microfluorometric recordings were performed from layer V pyramidal neurons in rat cortical slices to study the effects of SEL on the paroxysmal depolarization shifts (PDSs), and the simultaneous elevations of intracellular Ca2+ concentration [Ca2+]i. Moreover, the involvement of high‐voltage activated Ca2+ currents (HVACCs) was investigated by means of patch‐clamp recordings from acutely dissociated pyramidal neurons. Results: SEL significantly reduced both the duration of PDSs (IC50 = 241.0 ± 21.7 nm ) as well as the number of action potentials per PDS (IC50 = 82.7 ± 9.7 nm ). In addition, SEL largely decreased the [Ca2+]i rise accompanying PDSs (up to 75% of control values, IC50 = 345.0 ± 15.0 nm ). Furthermore, SEL significantly reduced HVACCs in pyramidal neurons. This effect was mimicked by ω‐conotoxin GVIA and, to a lesser extent, by ω‐conotoxin MVIIC, blockers of N‐ and Q‐type HVACC, respectively. The combination of these two toxins occluded the action of SEL, suggesting that N‐type Ca2+ channels, and partly Q‐type subtypes are preferentially targeted. Conclusions: These results demonstrate a powerful inhibitory effect of SEL on epileptiform events in vitro. SEL showed a higher potency than LEV. The effective limitation of [Ca2+]i influx might be relevant for its antiepileptic efficacy and, more broadly, for pathologic processes involving neuronal [Ca2+]i overload. 相似文献
8.
9.
浅析了中国GMP发展背景,针对2010版GMP(送审稿)——无菌制剂生产实施进行了探讨;并对比分析了国内外无菌分装剂设备的差距,供相关产品开发借鉴。 相似文献
10.
目的:介绍定量测定甲硝唑注射液中内毒素的方法并讨论相关问题。方法:采用细菌内毒素检查法和亲和膜分离法,定量检测稀释5倍的0.2%甲硝唑注射液和稀释13倍的0.5%的甲硝唑注射液中细菌内毒素(鲎试剂灵敏度0.125EU/ml)。结果:亲和膜分离法同细菌内毒素检查法比较接近。结论:亲和膜分离法临床应用简捷、快速,方法准确可靠。 相似文献