全文获取类型
收费全文 | 2523篇 |
免费 | 87篇 |
国内免费 | 58篇 |
专业分类
耳鼻咽喉 | 661篇 |
儿科学 | 18篇 |
妇产科学 | 14篇 |
基础医学 | 205篇 |
口腔科学 | 46篇 |
临床医学 | 505篇 |
内科学 | 114篇 |
皮肤病学 | 16篇 |
神经病学 | 284篇 |
特种医学 | 106篇 |
外科学 | 214篇 |
综合类 | 196篇 |
预防医学 | 40篇 |
眼科学 | 15篇 |
药学 | 140篇 |
中国医学 | 9篇 |
肿瘤学 | 85篇 |
出版年
2023年 | 22篇 |
2022年 | 43篇 |
2021年 | 51篇 |
2020年 | 54篇 |
2019年 | 68篇 |
2018年 | 67篇 |
2017年 | 65篇 |
2016年 | 59篇 |
2015年 | 78篇 |
2014年 | 137篇 |
2013年 | 199篇 |
2012年 | 121篇 |
2011年 | 138篇 |
2010年 | 103篇 |
2009年 | 126篇 |
2008年 | 120篇 |
2007年 | 109篇 |
2006年 | 95篇 |
2005年 | 84篇 |
2004年 | 87篇 |
2003年 | 84篇 |
2002年 | 59篇 |
2001年 | 77篇 |
2000年 | 70篇 |
1999年 | 55篇 |
1998年 | 35篇 |
1997年 | 48篇 |
1996年 | 33篇 |
1995年 | 43篇 |
1994年 | 36篇 |
1993年 | 35篇 |
1992年 | 22篇 |
1991年 | 15篇 |
1990年 | 19篇 |
1989年 | 20篇 |
1988年 | 13篇 |
1987年 | 12篇 |
1986年 | 13篇 |
1985年 | 19篇 |
1984年 | 14篇 |
1983年 | 12篇 |
1982年 | 8篇 |
1981年 | 16篇 |
1980年 | 10篇 |
1979年 | 19篇 |
1978年 | 21篇 |
1977年 | 7篇 |
1976年 | 9篇 |
1975年 | 5篇 |
1974年 | 3篇 |
排序方式: 共有2668条查询结果,搜索用时 651 毫秒
1.
M. R. D. Maslin S. K. Lloyd S. Rutherford S. Freeman A. King D. R. Moore K. J. Munro 《Journal of the Association for Research in Otolaryngology》2015,16(5):631-640
Individuals with sudden unilateral deafness offer a unique opportunity to study plasticity of the binaural auditory system in adult humans. Stimulation of the intact ear results in increased activity in the auditory cortex. However, there are no reports of changes at sub-cortical levels in humans. Therefore, the aim of the present study was to investigate changes in sub-cortical activity immediately before and after the onset of surgically induced unilateral deafness in adult humans. Click-evoked auditory brainstem responses (ABRs) to stimulation of the healthy ear were recorded from ten adults during the course of translabyrinthine surgery for the removal of a unilateral acoustic neuroma. This surgical technique always results in abrupt deafferentation of the affected ear. The results revealed a rapid (within minutes) reduction in latency of wave V (mean pre = 6.55 ms; mean post = 6.15 ms; p < 0.001). A latency reduction was also observed for wave III (mean pre = 4.40 ms; mean post = 4.13 ms; p < 0.001). These reductions in response latency are consistent with functional changes including disinhibition or/and more rapid intra-cellular signalling affecting binaurally sensitive neurons in the central auditory system. The results are highly relevant for improved understanding of putative physiological mechanisms underlying perceptual disorders such as tinnitus and hyperacusis. 相似文献
2.
《European annals of otorhinolaryngology, head and neck diseases》2019,136(3):151-154
ObjectivesTo develop an experimental protocol to study the vocal effort generated by introducing barriers to communication, and its relationship with certain personality traits.Material and methodsThe experimental protocol consisted of an interactive game in which the subject gave an investigator instructions to adopt various body positions (semi-directed communication situation). The Control situation included no constraints on communication. Then a Distance Constraint (increased distance between subject and investigator) and a Time Constraint (generation of performance stress by putting the subject in competition with others) were introduced. The vocal parameters studied comprised vocal intensity and fundamental frequency in the middle of the vowel of 3 target phonemes. Subjects also took the NEO FFI-R personality test.ResultsThe study included 41 women aged between 18 and 52 years. Vocal intensity and fundamental frequency increased significantly with the introduction of the constraints (P < 0.05), intensity passing from 75.5 dB to 81.8 dB and frequency from 249.4 Hz to 335.8 Hz. No correlations were found between these changes and results for the various personality traits.ConclusionsThis ecological protocol enables the impact of both physical and emotional obstacles to communication to be studied. No correlations between vocal effort and personality traits emerged. A larger-scale study would be necessary to analyze the continuum between vocal effort and vocal forcing, to improve speech therapy for dysfunctional dysphonia. 相似文献
3.
Anastasiia Panfilova Sarah E. Shelton Cristina Caresio Ruud J.G. van Sloun Filippo Molinari Hessel Wijkstra Paul A. Dayton Massimo Mischi 《Ultrasound in medicine & biology》2019,45(2):539-548
Dynamic contrast-enhanced ultrasound (DCE-US) has been proposed as a powerful tool for cancer diagnosis by estimation of perfusion and dispersion parameters reflecting angiogenic vascular changes. This work was aimed at identifying which vascular features are reflected by the estimated perfusion and dispersion parameters through comparison with acoustic angiography (AA). AA is a high-resolution technique that allows quantification of vascular morphology. Three-dimensional AA and 2-D DCE-US bolus acquisitions were used to monitor the growth of fibrosarcoma tumors in nine rats. AA-derived vascular properties were analyzed along with DCE-US perfusion and dispersion to investigate the differences between tumor and control and their evolution in time. AA-derived microvascular density and DCE-US perfusion exhibited good agreement, confirmed by their spatial distributions. No vascular feature was correlated with dispersion. Yet, dispersion provided better cancer classification than perfusion. We therefore hypothesize that dispersion characterizes vessels that are smaller than those visible with AA. 相似文献
4.
5.
Jae Hwang Song Chan Kang Deuk Soo Hwang Dong Hun Kang Yong Hwan Kim 《Foot and Ankle Surgery》2019,25(6):748-754
BackgroundThe purpose of this study was to investigate and compare the clinical outcomes of dorsal suspension with those of neurectomy for the treatment of Morton’s neuroma.MethodsWe conducted a retrospective study of dorsal suspension and neurectomy group. The dorsal suspension was performed by dorsal transposition of neuroma over the dorsal transverse ligament after neurolysis. The visual analog scale (VAS), the Foot and Ankle Ability Measure (FAAM), postoperative satisfaction, and complications were evaluated.ResultsBoth groups reported significant pain relief, and there were no significant differences between the groups with respect to postoperative pain. The postoperative FAAM outcomes showed no significant between-group differences. Satisfaction analysis showed ‘excellent’ and ‘good’ results in the dorsal suspension and neurectomy groups (95% and 77.7%, respectively). Complications of numbness and paresthesia reported in the dorsal suspension group (5% and 5%, respectively) were significantly fewer than those of neurectomy group (61.1% and 33.3%, respectively) (both, p < .05).ConclusionsWith its favorable results, dorsal suspension can be another operative option for the treatment of Morton’s neuroma.Level of Evidence: Level III, retrospective comparative case series. 相似文献
6.
7.
目的:评价耳蜗神经电位活动直接监护在听神经瘤手术中对保护听力的作用。方法:听神经瘤手术中施行耳蜗电图监护。结果:16例听神经瘤手术中施行耳蜗电图监护者,术后听力保留5例(31%),其中4例为有效听力保留。肿瘤在2厘米以下者听力保留为38%(5/13)。结论:听神经瘤手术过程中采用耳蜗电图监护,能敏感地反应即时的听神经功能状况,给术者及时的反馈信息,有助于听力保护 相似文献
8.
胎儿声振动刺激反应的研究 总被引:5,自引:0,他引:5
目的:了解不同孕龄胎儿对声振动刺激的反应。方法:对435例次正常中、晚期妊娠妇女进行声振胎心试验(VAS-T)、声振胎动试验(SPFM),并对声振动刺激前、后胎心率变化规律进行前瞻性研究。结果:(1)从24周开始,胎儿对声振刺激有反应,但大部分未能达到VAS-T诊断标准,而胎动反应良好。(2)妊娠28周开始,声振刺激后,90%以上的胎儿出现显著的胎动、胎心率加速反应,足月胎儿反应率在98%以上。(3)SPFM阳性率的显著提高早于VAS-T。提示:28周后胎儿神经系统发育已趋完善。胎儿运动神经的发育成熟早于植物神经。 相似文献
9.
Tilman Keck Kerstin Wiesmiller Joerg Lindemann Ajnacska Rozsasi 《European archives of oto-rhino-laryngology》2006,263(10):910-916
Acoustic rhinometry is one method to evaluate nasal geometry by an acoustic reflection technique. The aim of this study was to investigate the changes in acoustic rhinometry after nasal provocation in patients with exclusively perennial allergic rhinitis. In 19 patients, acoustic rhinometry and active anterior rhinomanometry were performed before and after nasal provocation test. There was a statistically significant nasal flow reduction measured by active anterior rhinomanometry after nasal provocation (p < 0.05) and a median symptom score of four points, both indicating a positive response to nasal provocation. On the other hand, there was no statistically significant change in the values of acoustic rhinometry after nasal provocation (p > 0.05). In patients with exclusively perennial allergic rhinitis, acoustic rhinometry does not seem to significantly change after nasal provocation. In contrast, active anterior rhinomanometry values decreased significantly after nasal provocation. The presented results indicate that acoustic rhinometry does not seem to be a diagnostic method superior to active anterior rhinomanometry in this context. 相似文献
10.
目的 探讨近端/远端复合肌肉动作电位振幅比率在术后面神经肿瘤侵犯段功能评估上的价值和对早期面神经修复的指导意义。方法 比较术末面神经近端/远端复合肌肉动作电位振幅比率和术后2周、6个月患侧面神经功能的H-B分级之间的关系。结果 术后6个月面神经H-B分级恢复到Ⅰ-Ⅱ级者,术末近端/远端复合肌肉动作电位振幅比率均>0.3。结论 术末面神经近端/远端复合肌肉动作电位振幅比率是判断术后面神经远期功能,特别是肿瘤侵犯段功能的重要指标,为术中直接修复面神经提供了指导依据。 相似文献