信息集萃

中医典籍研究与英译工程启动中国社会科学院罗希文研究员从上世纪70年代初开始进行《本草纲目》的英译工作,前期准备工作用了20年,正式翻译用了10年。此书最近由外文出版社出版。译著共6卷,600多万字。罗希文1983年获得中国社会科学院研究生院法学硕士学位,1985年获得美国洛杉矶中西医科大学东方医学哲学博士学位,现为中国社会科学院哲学所研究员,国家级有突出贡献专家,享受国务院政府津贴。1979年至1982年就读中国社科院研究生院期间,罗希文翻译了中医学经典之一的《伤寒论》。1985年,由英国著名学者李约瑟作序,英文本《伤寒论》在中国大陆…     

抗疟药氯喹可能抑制某些癌症的发生

上个世纪70年代—年代,坦桑尼亚的研究者给儿童分发了上百万剂疟疾特效药氯喹作为5年疟疾预防工作的一部分。然而该研究未能得出明确的结论,但研究人员在注意到有一种称之为伯吉特淋巴瘤的血癌病例却显著下降了。小鼠实验证明了氯喹真的可能防止伯吉特淋巴瘤以及一种罕见的叫作     

Ability of a Specific ERK Signal-Pathway Inhibitor to Reverse P-Glycoprotein- Mediated Vincristine Resistance in Colon Cancer Cell Unes

OBJECTIVE To investigate the effect of a specific inhibitor PD098059 of the extracellular-signal regulated protein kinase (ERK) pathway on the P-glycoprotein (P-gp)-mediated resistance of colon cancer cell lines SW480/VCR and CoLo205NCR.METHODS SW480NCR and CoLo205NCR cells were generated byexposuring SW480 and CoLo205 cells to vincristine (VCR) (30 ng/ml) for 72h, which resulted in a comparatively higher level of P-gp expression.Western blotting was used to analyze P-gp, MRP, LRP, GST-‘rr and TOPOIIexpression after exposuring the SW480 and CoLo205 cells to VCR (30 ng/ml)for 72 hrs. P-gp and pERK1/2 expressions was analyzed in SW480NCR andCoLo205/VCR cells treated with or without the specific inhibitor of MEK,PD098059. The MTT assay was used to determine the susceptibility ofSW480NCR and CoLo205NCR cells to VCR, treated with or withoutPD098059.I~F.SULI“S The results showed that VCR induced a comparatively higher levelof P-gp expression in the cell lines, but not that of MRP, LRP, GST-n- orTOPOII. P-gp expression levels were depressed significantly in SW480/VCR and COLO205/VCR cells by the specific inhibitor of MEK, PD098059.The IC50 (248 19.6 and 215 10.7 ng/ml) to VCR of SW480/VCR andCoLo205/VCR cells exhibited a 2.16 and 2.03-fold higher resistancecompared to the negative control group (SW480 and CoLo205 cells)(115 15.6 and 106 11.9 ng/ml), but a 1.35 and 1.21 -fold higher resistance thanthe group treated with VCR (30 ng/ml) PD098059 (184 21.8 and 177 19.4 ng/ml).CONCLUSION This study shows that the expression of P-gp can beinduced by exposuring cells to VCR, and that this induction can be reversedby inhibiting the ERK signaling pathway at the point of MEK by its specificinhibitor, PD098059. The ERK signal-transduction pathway may play a rolein modulating mdrl expression in colon cancer.     

海中珍品话牡蛎

牡蛎，俗称蚝，别名蛎黄、海蛎子，属贝类，其口味鲜美，营养丰富：世界上总计约有100多种，我国沿海约有20余种。     

广东省蜂密产品居然有七成是糖水勾兑

由中国工程院院士钟南山任首席顾问、广州一家高新企业主持的广东省科技攻关项目“防治SARS疾病特效SANA药物研究”课题组，最近在应用新技术研发SARS特效药方面取得阶段性重要成果。     

肝炎病人的饮食营养宜忌

肝炎目前尚无特效药，多采用中西医结合的办法，促进肝代谢，调整免疫功能及缓解症状，饮食营养治疗十分重要。合理的饮食营养能为受损的肝细胞提供恢复的物质基础，有利于病体康复。     

A candidate DNA vaccine elicits HCV specific humoral and cellular immune responses

AIM: TO investigate the immunogenicity of candidate DNA vaccine against hepatitis C virus (HCV) delivered by two plasmids expressing HCV envelope protein 1 (El) and envelope protein 2 (E2) antigens respectively and to study the effect of CpG adjuvant on this candidate vaccine.METHODS: Recombinant plasmJds expressing HCV EI and E2 antigens respectively were used to simultaneously inoculate mice with or without CpG adjuvant. Antisera were then collected and tJters of antJ-HCV antibodies were analyzed by ELISA. One month after the last injection, animals were sacrificed to prepare single-cell suspension of splenocytes.These cells were subjected to HCV antigen specific proliferaion assays and cytokine secretion assays to evaluate the cellular immune responses of the vaccinated animals.RESULTS: Antibody responses to HCV EI and E2 antigens were detected in vaccinated animals. Animals receiving CpG adjuvant had slightly lower titers of anti-HCV antibodies in the sera, while the splenocytes from these animals showed higher HCV-antigen specific proliferation. Analysis of cytokine secretion from the splenocytes was consistent with the above results. While no antigen-specific IL-4 secretion was detected for all vaccinated animals, HCV antigen-specific INF-γ, secretion was detected for the splenocytes of vaccinated animals. CpG adjuvant enhanced the secretion of INF-γ, but did not change the profile of IL-4 secretion.CONCLUSION: Vaccination of mice with plasmids encoding HCV E1 and E2 antigens induces humoral and cellular immune responses. CpG adjuvant significantly enhances the cellular immune response.     

爱治疗她心病的特效药

晓云是个二十出头的农村姑娘,她得了一种心病;怕见外人,特别是怕看到别人的目光。晓云上小学时,是个品学兼优的好学生,上初中后,她却被班上一个坏女孩引诱,经常带她到外面“见识世界”,     

轻松站桩快乐降糖

糖尿病是严重危害人类健康的常见病、多发病。其中2型糖羼病占糖尿病总数的90％～95％,目前尚缺乏彻底根治糖尿病的特效药。