全文获取类型
收费全文 | 6543篇 |
免费 | 327篇 |
国内免费 | 188篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 51篇 |
妇产科学 | 20篇 |
基础医学 | 568篇 |
口腔科学 | 61篇 |
临床医学 | 314篇 |
内科学 | 465篇 |
皮肤病学 | 85篇 |
神经病学 | 1175篇 |
特种医学 | 309篇 |
外科学 | 189篇 |
综合类 | 341篇 |
预防医学 | 456篇 |
眼科学 | 16篇 |
药学 | 2517篇 |
1篇 | |
中国医学 | 213篇 |
肿瘤学 | 247篇 |
出版年
2024年 | 6篇 |
2023年 | 36篇 |
2022年 | 72篇 |
2021年 | 98篇 |
2020年 | 107篇 |
2019年 | 83篇 |
2018年 | 131篇 |
2017年 | 113篇 |
2016年 | 152篇 |
2015年 | 147篇 |
2014年 | 289篇 |
2013年 | 324篇 |
2012年 | 313篇 |
2011年 | 451篇 |
2010年 | 341篇 |
2009年 | 333篇 |
2008年 | 378篇 |
2007年 | 357篇 |
2006年 | 328篇 |
2005年 | 234篇 |
2004年 | 336篇 |
2003年 | 327篇 |
2002年 | 242篇 |
2001年 | 161篇 |
2000年 | 181篇 |
1999年 | 68篇 |
1998年 | 100篇 |
1997年 | 110篇 |
1996年 | 101篇 |
1995年 | 94篇 |
1994年 | 76篇 |
1993年 | 71篇 |
1992年 | 71篇 |
1991年 | 67篇 |
1990年 | 71篇 |
1989年 | 60篇 |
1988年 | 58篇 |
1987年 | 53篇 |
1986年 | 80篇 |
1985年 | 88篇 |
1984年 | 81篇 |
1983年 | 74篇 |
1982年 | 44篇 |
1981年 | 34篇 |
1980年 | 46篇 |
1979年 | 28篇 |
1978年 | 12篇 |
1977年 | 12篇 |
1976年 | 4篇 |
1975年 | 6篇 |
排序方式: 共有7058条查询结果,搜索用时 15 毫秒
1.
《Journal of labelled compounds & radiopharmaceuticals》2006,49(4):339-343
Condensation of thiourea 1 with diethyl malonate 2 in the presence of sodium methoxide furnished 4,6‐dihydroxy‐2‐mercaptopyrimidine 3 . Compound 3 on methylation with diazomethane followed by oxidation with H5IO6/CrO3 in ethyl acetate gave 4,6‐dimethoxy‐2‐methylsulphonylpyrimidine 5 . Compound 5 on condensation with 2‐mercapto‐6‐chlorobenzoic acid in the presence of a phase transfer catalyst, tetrabutylammonium bromide and sodium carbonate gave the title compound – pyrithiobac‐sodium 6 with an overall yield of > 35% starting from thiourea. Following the above standardized procedure, using [14C]‐thiourea in lieu of thiourea, 14C labelled product 6 , was synthesized with an overall radiochemical yield > 30% (with respect to [14C]‐thiourea) for further evaluations of environmental fate of 6 , in soils and plants. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
2.
Jen auo Hirschberg 《Early child development and care》1990,65(1):57-69
During a period of twenty years [1969-1988] the author has observed 614 cases of congenital malformations and noninflammatory diseases of the larynx in infants and young children, Budapest. He summarizes the most characteristic symptoms of laryngeal pathology in infants, and discusses the diagnostic possibilities. Among the latter, spectrographic analyses complemented by auditory evaluation of pathological cry and different breathing noises play an important role. Based on his investigation author differentiates 20 kinds of pathological crying sounds and 4 basic forms of stridor. He describes the acoustic attributes of different pathological sound phenomena and summarizes characteristic voice changes. 相似文献
3.
《Journal of labelled compounds & radiopharmaceuticals》2005,48(9):693-700
[(1R)‐endo]‐(+)‐3‐bromocamphor was dehalogenated with tritium gas to [3‐3H]camphor and via [3‐3H]phenylborneol converted to [3‐3H]deramciclane isolated as the fumarate salt (specific activity 51.8 GBq/mmol). This three step synthesis from [3‐3H]camphor gave an overall yield of 22%. Benzyloxy‐acetic acid methyl ester was reduced with sodium‐borotritide to 2‐benzyloxy‐ethanol‐[1‐3H], and through a four step procedure was converted to 2‐dimethylaminoethyl‐[2‐3H] chloride. The latter was condensed with the sodium derivative of 2‐phenylborneol giving rise to [2‐dimethylamino‐[2‐3H]ethoxy]deramciclane isolated as the fumarate (specific activity 8.177 GBq/mmol). This six step synthesis from [3H]NaBH4 gave an overall yield of 6%. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
4.
《Journal of labelled compounds & radiopharmaceuticals》2003,46(6):531-537
Exposure of captodative enone systems to deuterium in the presence of Crabtree's catalyst ( 1 ) results in deuteration at the vinylic site β‐ to the ketone carbonyl, as well as at any accessible ortho‐position. β‐exchange is also observed during the reduction of ethyl cinnamate ( 3 ) catalyzed by 1 . Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
5.
钙拮抗剂TMB-8抑制BHQ,NE和KCl引起的培养乳牛基底动脉单个平滑肌细胞内游离钙的升高 总被引:1,自引:0,他引:1
用AR CM MIC阳离子测定系统,测量单个细胞内游离钙浓度([Ca2+]i),研究8-(N,N-二乙胺)-n-辛基 3,4,5-三甲氧基苯甲酸酯(TMB-8)对培养乳牛基底动脉平滑肌[Ca2+]i的作用。在细胞外钙浓度为1.3mmol·L-1时,TMB-8(30μmol·L-1)可明显抑制BHQ,NE及KCl引起[Ca2+]i的升高。在细胞外钙为零+EGTA 0.1mmol·L-1时,TMB-8(10,30及100μmol·L-1)可浓度依赖性地降低静息[Ca2+]i,TMB-8(30μmol·L-1)可几乎完全阻断BHQ及NE引起[Ca2+]i的增加。研究表明TMB-8降低培养乳牛基底动脉平滑肌[Ca2+]i的机制,主要是抑制肌浆网Ca2+的释放,或增加肌浆网对Ca2+的摄入,并由此间接地抑制细胞外钙的内流。 相似文献
6.
Australian nursing has undergone rapid academization in the past 10 years and this radical change has tended to meld the somewhat different academic traditions of North America and Britain. The introduction of doctoral education in nursing in 1987 has led to a massive increase in scholarly activity and to the preparation of talented leaders. We concur with the view expressed by Henry (1997), "I am convinced that the problems we face in the nursing services would be much more creatively solved if the majority of our doctoral programs prepared young, energetic nurses, early in their career, for clinical practice, not for research and teaching" (p. 162). 相似文献
7.
An investigation has been made into the effect of 3,4-methylenedioxymethamphetamine (MDMA or ‘Ecstasy’) administration on the concentration of 5-hydroxytryptamine (5-HT), uptake of [3H]5-HT and [3H]paroxetine binding in rat cerebral cortex tissue. Four days after 2 injections of MDMA (20 mg/kg i.p., 6 hr apart) the concentrations of 5-HT and its metabolite 5-HIAA were reduced by 60%. The binding of [3H]paroxetine to the presynaptic 5-HT transporter was decreased and high affinity uptake of [3H]5-HT was reduced by a similar amount, indicating neurodegeneration of 5-HT terminals. Pretreatment with chlormethiazole (100 mg/kg i.p.), 10 min before each MDMA injection prevented the decrease in both [3H]parotextine binding and uptake of [3H]5-HT. The loss in 5-HT and 5-HIAA content was also attenuated. Pretreatment with dizocilpine (1 mg/kg i.p.) or haloperidol (2 mg/kg i.p.) also prevented the MDMA-induced loss of [3H]paroxetine binding and attenuated the loss of 5-HT and 5-HIAA content. All three compounds also decreased the degree of hyperthermia that follows MDMA administration, although previous studies suggest that the long term neurodegeneration is not associated with the acute hyperthermic response. These data support the findings of others that MDMA injection produces degeneration of 5-HT nerve terminals in the cortex, confirm that chlormethiazole, dizocilpine and haloperidol attenuate MDMA-induced neurotoxic loss of 5-HT and demonstrate for the first time that these compounds prevent the neurodegeneration of 5-HT nerve terminals that follows MDMA administration. 相似文献
8.
目的:研究脑缺血后脑片[Ca2+]i变化。方法:采用新型Ca2+荧光指示剂Fura-2双波长法测定兔大脑中动脉阻塞(MCAo)局灶脑缺血后脑片细胞内游离钙([Ca2+]i)。结果:脑缺血后脑组织[Ca2+]i显著升高。结论:[Ca2+]i在脑缺血损害中起重要作用。 相似文献
9.
Jordi Llorens Cristina Su ol Josep M. Tusell Eduard Rodrí guez-Farr 《Neurotoxicology and teratology》1990,12(6):607-610
The inhibition of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding to the GABAA receptor by the insecticide γ-hexachlorocyclohexane, lindane, was studied in several brain regions and using different membrane preparation methods, both in vitro and after dosing the animals with the chemical. In the latter studies, the amount of lindane remaining in the membrane suspensions used for binding assays was determined. In vitro data showed values of IC50 from 150 to 1675 nM, varying in function of the membrane preparation method used. This may account for the discrepancies in IC50 values found in the literature. IC50 values within the range of 150–250 nM were determined using extensively washed membranes from several brain regions, so no evidence arose for brain regional differences in the affinity of lindane for the TBPS binding site. After different schedules of acute treatment with lindane, we found a manifest relationship between the extent of the observable inhibition of [35S]TBPS binding and the lindane amount remaining in the membrane suspensions used for binding assays. This relationship was in good agreement with the in vitro data, so no support for an in vivo acute regulation of the binding site was obtained. 相似文献
10.
Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi 总被引:6,自引:0,他引:6
R Docampo S N Moreno J F Turrens A M Katzin S M Gonzalez-Cappa A O Stoppani 《Molecular and biochemical parasitology》1981,3(3):169-180
Miconazole and econazole, two fungicide imidazole derivatives, completely inhibited growth of Trypanosoma cruzi (Tulahuen strain) at concentrations of about 20 muM. Culturing of T. cruzi in the presence of lower doses of imidazole derivatives produced: decrease of 5,7-diene sterol content in epimastigotes (including ergosterol); disappearance of the nuclear chromatin, vacuolization and decrease in the electron density of the cytoplasm; selective surface alterations as revealed by an increased response to wheat-germ- and phytohemagglutinin. At variance with the effect of miconazole on Candida (De Nollin et al. (1977) Antimicrobial. Agents Chemother. 11, 500-513), miconazole and econazole, under the experimental conditions used, did not increase the rate of hydrogen peroxide generation by T. cruzi. 相似文献