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《Journal of labelled compounds & radiopharmaceuticals》2004,47(1):25-30
Enterolactone and enterodiol are the main mammalian metabolites of dietary butyrolactone type lignans. The study of biological properties and potential health effects of these compounds requires isotopically labelled compounds as standards for quantitative measurements. An expedient deutero‐labelling method for enterolactone is to use the D3PO4·BF3/D2O complex at room temperature which will exchange all eight aromatic hydrogens, even from inactivated meta positions, to form [2,4,5,6,2′,4′,5′,6′‐2H8]‐enterolactone in 74% yield and 99% isotopic purity. [2,4,5,6,9,9,2′,4′,5′,6′‐2H10]‐Enterodiol was prepared from [2,4,5,6,2′,4′,5′,6′‐2H8]‐enterolactone by reduction with LiAlD4 which introduces two more deuterium atoms into the molecule. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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Functional foods have nutritional properties and organic functions, which are beneficial to health. Certain types of functional food components are so‐called phytoestrogens, non‐steroidal compounds derived from the metabolism of precursors contained in plants, which originate secondary metabotypes known to induce biological responses and by mimicry or modulating the action of endogenous estrogen. These molecules are involved in several physiological and pathological processes related to reproduction, bone remodeling, skin, cardiovascular, nervous, immune systems, and metabolism. This review aimed to present an overview of phytoestrogens regarding their chemical structure, actions, and effects in the organism given several pathologies. Several studies have demonstrated beneficial phytoestrogen actions, such as lipid profile improvement, cognitive function, menopause, oxidative stress, among others. Phytoestrogens effects are not completely elucidated, being necessary future research to understand the exact action mechanisms, whether they are via estrogen receptor or whether other hidden mechanisms produce these effects. Thus, this review makes a general approach to the phytoestrogen actions, beneficial effects, risk and limitations. However, the complexities of biological effects after ingestion of phytoestrogens and the differences in their metabolism and bioavailability indicate that interpretation of either risk or benefits needs to be made with caution. 相似文献
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Hedelin M Bälter KA Chang ET Bellocco R Klint A Johansson JE Wiklund F Thellenberg-Karlsson C Adami HO Grönberg H 《The Prostate》2006,66(14):1512-1520
BACKGROUND: The causes of prostate cancer are poorly understood, but genetic factors may be more important than for many other malignancies, and dietary phytoestrogens may be protective. Because phytoestrogens bind tightly to the estrogen receptor-beta, we conducted an epidemiologic investigation of synergistic effects between phytoestrogen intake and estrogen receptor-beta gene polymorphisms. METHODS: We performed a population-based case-control study in Sweden. All participants reported their phytoestrogen intake and donated a blood sample. We identified four haplotype-tagging single nucleotide polymorphisms (htSNPs) and genotyped these htSNPs in 1314 prostate cancer patients and 782 controls. Odds ratios were estimated by multivariate logistic regression. Interactions between phytoestrogen intake and estrogen receptor-beta SNPs on prostate cancer risk were evaluated considering both multiplicative and additive effect scales. RESULTS: We found a significant multiplicative interaction (P = 0.04) between dietary intake of phytoestrogens and a promoter SNP in the estrogen receptor-beta gene (rs 2987983-13950), but not with any of the three other htSNPs (P = 0.11, 0.69, 0.85). Among carriers of the variant promoter alleles, we found strong inverse associations with increasing intake of total phytoestrogens (odds ratio for highest vs. lowest quartile = 0.43; P for trend <0.001), isoflavonoids (odds ratio = 0.63; P for trend = 0.05), and coumestrol (odds ratio = 0.57; P for trend = 0.003). We found no association between phytoestrogens and prostate cancer among carriers homozygous for the wild-type allele (TT). CONCLUSIONS: Our study provides strong evidence that high intake of phytoestrogens substantially reduce prostate cancer risk among men with specific polymorphic variation in the promoter region of the estrogen receptor-beta gene. 相似文献
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补骨脂素的植物雌激素作用及其机制探讨 总被引:4,自引:1,他引:4
目的:利用雌激素受体(ER)α,β阳性T47D细胞和子宫内膜癌Ishikawa细胞观察补骨脂素的雌激素样作用,并探讨其可能的作用机制。方法:以1×10-8mol.L-1雌二醇(E2)为阳性对照药,利用MTT细胞增殖试验观察1×10-5~1×10-9mol.L-1补骨脂素对T47D增殖的影响,同时观察1×10-6mol.L-1和1×10-7mol.L-1补骨脂素对Ishikawa细胞增殖的影响;以半定量RT-PCR法检测1×10-6mol.L-1和1×10-7mol.L-1补骨脂素对T47D细胞雌激素效应基因PR mRNA表达情况的影响;并以雌激素受体拮抗剂ICI 182,780为工具药进行干预。同时,通过流式细胞术检测1×10-6mol.L-1和1×10-7mol.L-1补骨脂素引起T47D细胞ER-α,ER-β含量的变化。结果:1×10-5~1×10-7mol.L-1补骨脂素能够显著促进T47D细胞增殖;1×10-6mol.L-1和1×10-7mol.L-1补骨脂素对Ishikawa细胞增殖也有显著的促进作用;RT-PCR结果显示:1×10-6mol.L-1和1×10-7mol.L-1补骨脂素可使T47D细胞PR mRNA表达显著增加,表现出雌激素样作用,而且以上效应可被ICI 182,780拮抗。1×10-6mol.L-1和1×10-7mol.L-1补骨脂素还可诱导T47D细胞ER-α,ER-β表达明显增加。结论:补骨脂素具有植物雌激素作用,并且其作用是通过ER途径介导的。 相似文献
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红花等10种中药的植物雌激素活性研究 总被引:26,自引:2,他引:26
目的:评价红花、川牛膝、丹参、女贞子、枸杞、甘草、肉苁蓉、淫羊藿、补骨脂、菟丝子等10味中药的植物雌激素活性。方法:选用昆明种雌性乳鼠,随机分为A,B二组:A组又分为12组(溶剂对照组、己烯雌酚组和10个中药组);B组也分为12组(溶剂对照组、己烯雌酚组和10个中药拮抗组),其中中药拮抗组每天同时灌胃中药和己烯雌酚;各组给药4 d后分离血清。利用雌激素受体(ER)阳性MCF-7细胞,以MTT法检测中药含药血清对细胞增殖的影响。结果:A组中,红花、川牛膝、丹参、枸杞、肉苁蓉、淫羊藿、补骨脂和菟丝子等中药含药血清可显著促进MCF-7细胞增殖;而女贞子组可见细胞增殖受到明显抑制。B组中,红花、川牛膝、丹参、甘草、淫羊藿、补骨脂和菟丝子组可见己烯雌酚促细胞增殖的作用受到了显著抑制;而肉苁蓉可协同并显著增强己烯雌酚促细胞增殖的作用。结论:红花、川牛膝、丹参、淫羊藿、补骨脂、菟丝子等6种中药在单独用药时具有拟雌激素作用,在与雌激素同时用药时具有抗雌激素作用,其双向调节效应依赖于体内雌激素水平的高低。 相似文献
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大豆异黄酮心血管作用的研究进展 总被引:6,自引:0,他引:6
异黄酮是一类具有雌激素样作用的生物活性物质。大豆中的异黄酮主要有两种形式:染料木黄酮和黄豆苷原。近年来发现,大豆异黄酮具有较强的扰动脉粥样硬化和舒血管效应,影响细胞增殖和新生血管的形成,对心血管有保护和调节作用。 相似文献
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为了探讨槲皮素对3周龄小鼠卵巢发育和血浆中激素水平的影响,本研究使用槲皮素对3周龄小鼠进行连续灌胃(45、25和5 mg·kg-1.d-1)50天,定期监测发情周期和血液中相关激素水平变化;处死动物后取出卵巢进行组织形态分析,观察各级卵泡及其PCNA染色细胞的比例。结果显示,槲皮素组较空白对照组能增加卵巢的器官指数(P<0.05),能提高原始卵泡和次级卵泡的比例(P<0.05)并降低成熟卵泡、闭锁卵泡和黄体的比例(P<0.05),能有效提高各级卵泡中增殖细胞的比例(P<0.05),对于小鼠血液中各激素水平有较为明显的影响(P<0.05),尤其是卵泡刺激素(FSH)和黄体生成素(LH)。由此可见,槲皮素在小鼠卵巢发育阶段呈现出一定的类雌激素的性质,在幼鼠发育阶段长期摄入槲皮素,将影响其卵巢发育以及体内相关的激素水平。 相似文献