Monitoring island flap for fibular graft in 30 patients with long bone defects

To study the effect of vascularized fibulargraft on large defects of long bones and the monitoringmethod for the vascular status of the grafted fibula.     

纤维连接蛋白对生物矿化影响的体外实验研究

目的:探讨纤维连接蛋白(Fn)对生物矿化过程的影响,为其应用于临床作盖髓剂提供理论依据.方法:应用体外凝胶矿化系统结合微观形态学观察,研究有无羟基磷灰石(HAP)晶核时Fn对钙磷沉积的影响.结果:凝胶体系中随Fn浓度升高,吸光度值也升高(P<0.01),表明磷酸钙沉淀量的增多;加入HAP并不降低Fn的促沉积活性.结论:Fn可能通过促进钙磷沉积及其与HAP的相互作用参与矿化过程,此特性可能有利于Fn作为盖髓剂成份诱导牙本质桥形成.     

大脑中动脉钙化的CT与经颅多普勒超声对照研究

目的探讨大脑中动脉（middle cerebral artery,MCA）水平段（M1）钙化的量化指标与血流动力学的关系。资料与方法搜集经头颅CT确诊M1段钙化且行经颅多普勒超声（transcranial Doppler,TCD）检查者41例,按有无钙化分为钙化组和无钙化组。分析MCA钙化组血流动力学参数与钙化量化指标是否有相关性;检验钙化组与无钙化组血流动力学参数及狭窄发生率的差异。结果MCA搏动指数（pulsatility index,PI）与钙化体积以及积分值呈线性相关;钙化组与无钙化组PI差异有统计学意义（P〈0.05）,但狭窄发生率差异无统计学意义（P〉0.05）。结论MCA钙化程度与TCD反映血管弹性的PI相关,但与反映狭窄程度的血流速度无相关性。     

An expert system to teach troubleshooting of common problems associated with the automated anesthesia recordkeeper

Automated anesthesia recordkeepers have been used to monitor patients during surgery in up to 90% of cases at The Ohio State University. The record-keeping devices are complex and can be difficult to troubleshoot. The 1st-CLASS Fusion Program, an expert system shell-program, has been programmed to allow the resident or nurse anesthetist to solve the two most common types of problems associated with the recordkeeper: printer problems and patient monitor problems. Use of this program allows the resident or nurse anesthetist to troubleshoot the recordkeeper quickly and accurately and promotes in the user a sense of competence and control over the technology.     

生理性近视眼

作者统计分析1999名学生及学龄前儿童(4～18岁)正常眼的视力及睫状肌麻痹下的屈光,发现各年龄组屈光度都可计算出一定范围的正常值,并呈现正态分布曲线。结合其他观察比较,特提出生理性近视眼的概念,并就其表现特点及其与病理性近视眼的区别,作了详细讨论。对于人群中大量存在的生理性近视眼(或称单纯性近视眼),作者认为可看作是现代文明社会中的一种适应性结果,属于一类生物学变异,而不是一种眼病。     

Physiologic model for the pharmacokinetics of 2′deoxycoformycin in normal and leukemic mice

A flow-limited physiologic mathematical model has been developed to describe the time course of 2deoxycoformycin (2dCF) concentrations in the plasma and tissues of mice following iv and ip doses. Urinary excretion is modeled as a linear process involving filtration and secretion, since kidney clearance exceeded estimated glomerular filtration rate. Intracellular binding is described as the sum of linear nonspecific binding plus strong saturable binding to adenosine deaminase. Pharmacokinetic parameters are determined by a sequential optimization scheme in which each tissue is studied by means of a hybrid model. The model has been used to predict pharmacokinetic behaviour of 2dCF in both normal and leukemic mice, and model simulations are compared with published data.