Study on the Value of Ultrasound Elastography Combined with Plasma miRNA Expression in the Early Detection of Breast Cancer

Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality are increasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnostic methods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent. Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography (UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measure the expression levels of miR-144-5p and miR-26b-5p in the plasma of patients with BC. The receiver operating characteristics (ROC) curve and area under the curve (AUC) were used to investigate the potential diagnostic value of miR- 144-5p, miR-26b-5p and the elastographic score in BC. Results: The ultrasonic elastography score(UES) was found to be significantly upregulated in BC compared with that in benign breast lesions, and the AUC, sensitivity and specificity were 0.809, 0.717 and 0.806 for distinguishing BC from benign breast lesions, respectively. miR-144-5p and miR-26b- 5p were found to be upregulated in the plasma of BC patients, and miR-144-5p+miR-26b-5p had 0.781 sensitivity and 0.780 specificity for the diagnosis of BC. Furthermore, we found that the diagnostic performance of miR-144-5p and miR-26b-5p combined with UES for BC had 0.913 sensitivity and 0.890 specificity. Conclusions: The combination of plasma miR-144-5p, miR-26b-5p and UES has a very high clinical application value for the early detection of BC.     

对比四维子宫输卵管超声造影与子宫输卵管造影评估输卵管通畅性效能:Meta分析

目的 采用Meta分析对比四维子宫输卵管超声造影（4D-HyCoSy）与子宫输卵管造影（HSG）评估输卵管通畅性的效能。方法 系统搜索PubMed、Cochrane Library、Embase、Web of Science、中国生物医学文献数据库、中国知网、万方医学网及维普数据库中建库至今有关4D-HyCoSy和/或HSG评估输卵管通畅性的文献。由2名研究人员依据纳入标准和排除标准筛选文献并提取信息；分别计算4D-HyCoSy和HSG评估输卵管通畅性的合并敏感度（SEN）、特异度（SPE）及诊断比值比（DOR），绘制综合受试者工作特征（SROC）曲线，获得曲线下面积（AUC），并以Medcalc 19.1.1统计软件比较AUC。结果 最终纳入19篇文献、1 358例疑似输卵管因素导致不孕患者，其中4篇同时采用4D-HyCoSy及HSG评估输卵管通畅性，10篇仅以4D-HyCoSy评估，5篇仅以HSG评估。Meta分析结果显示，4D-HyCoSy评估输卵管通畅性的合并SEN、SPE及DOR分别为0.92[95%CI（0.91，0.94）]、0.91[95%CI（0.89，0.93）]及115.06[95%CI（54.23，224.10）]；HSG评估输卵管通畅性的合并SEN、SPE及DOR分别为0.84[95%CI（0.81，0.87）]、0.80[95%CI（0.76，0.83）]及28.64[95%CI（10.08，81.35）]。4D-HyCoSy评估输卵管通畅性的AUC为0.98[95%CI（0.96，0.99）]，HSG为0.93[95%CI（0.90，0.95）]，差异有统计学意义（Z=6.97，P<0.01）。结论 4D-HyCoSy评估输卵管通畅性的效能高于HSG。     

Computed tomography imaging features for amyloid dacryolith in the nasolacrimal excretory system: A case report

BACKGROUNDNasolacrimal duct obstruction leading to epiphora is a common ophthalmologic complaint, and it may derive from amyloidosis in rare cases. There are a few reports about localized amyloidosis, and amyloidosis with involvement and obstruction of the nasolacrimal duct is exceedingly rare. CASE SUMMARYA 54-year-old male presented with a 2-year history of a lump overlying the left lacrimal sac that had grown rapidly for nearly half a year. Physical examination touched a firm lump in the left lacrimal sac. Nasal endoscopy discovered lesions in appearance of sediments with easy bleeding at the entry of the nasolacrimal duct of the left inferior nasal meatus. Computerized tomography scan revealed speckle high density in the left lacrimal sac and the dilated nasolacrimal duct. During an endoscopic exploration and excision, a large number of dacryoliths were exposed. Pathology indicated amorphous pink material and multinucleated giant cell reaction in the fibrous tissue.CONCLUSIONThis case showed amyloidosis in localized form mimicking dacryolith with nasolacrimal duct obstruction. In clinical practice, we should be aware of the possibility of localized amyloidosis in the nasolacrimal excretory system.     

白内障围手术期结膜囊菌群分布及药敏试验

目的 分析白内障围手术期结膜囊菌群的分布及药敏试验结果。方法 选取264例白内障患者,分别在患者入院后、手术消毒前、手术消毒后、手术结束后四个时间点取样,进行细菌培养及药敏试验,比较不同时期的细菌培养结果和药敏结果。结果 入院后结膜囊细菌培养阳性率明显高于手术消毒前、手术消毒后及手术结束后;入院后结膜囊细菌培养以表皮葡萄球菌为主;革兰氏阳性球菌对头孢西丁、加替沙星、左氧氟沙星等敏感性较高。结论 表皮葡萄球菌是结膜囊最常见的细菌,术前应常规应用抗生素点眼,聚维酮碘冲洗结膜囊等来预防术后感染性眼内炎。     

上下泪小管同时断裂35例手术分析

目的探讨上、下泪小管同时断裂的手术治疗方法。方法上、下泪小管同时断裂共35例,按手术方式分为两组。A组:27例同时行上、下泪小管吻合术;B组:8例仅行下泪小管吻合术。结果A组27例较少发生内眦角变形、睑外翻,上下泪点复位良好。结论为求上、下泪小管断裂术后能达到解剖复位及功能复位,同时行上、下泪小管断裂吻合效果较好。     

改良泪道探通术治疗新生儿泪囊炎

新牛儿泪囊是婴幼儿常见病，作者应用自制的泪道探通冲洗针对28例新生儿泪囊炎进行了泪道探通冲洗治疗观察．疗效满意．报告如下。     

An XPS and SEM evaluation of six chemical and physical techniques for cleaning of contaminated titanium implants

The purpose of the present study was to analyse clinically failed and retrieved implants prior to and after cleaning by means of scanning electron microscopy (SEM) and X-ray induced photoelectron spectroscopy (XPS) as compared to unused controls. Six different chemical and physical techniques for cleaning of contaminated titanium implants were evaluated: 1) rinsing in absolute ethanol for 10 min, 2) cleaning in ultrasonic baths containing trichloroethylene (TRI) and absolute ethanol, 10 min in each solution, 3) abrasive cleaning for 30 s, 4) cleaning in supersaturated citric acid for 30 s, 5) cleaning with continuous CO2-laser in dry conditions at 5 W for 10 s, 6) cleaning with continuous CO2-laser in wet conditions (saline) at 5 W for 10 s. SEM of failed implants showed the presence of contaminants of varying sizes and XPS showed almost no titanium but high carbon signals. XPS of unused titanium implants showed lower levels of titanium as previously reported, probably due to contamination of carbon which increased with time in room air. Cleaning of used implants in citric acid followed by rinsing with deionized water for 5 min followed by cleaning in ultrasonic baths with TRI and absolute ethanol gave the best results with regard to macroscopical appearance and surface composition. However, as compared to the unused implants the results from an element composition point of view were still unsatisfactory. It is concluded that further development and testing of techniques for cleaning of organically contaminated titanium is needed.     

小横切口手术治疗小儿腹股斜疝

目的：探讨小儿腹股沟斜疝手术方法。方法：经外环小横切口行疝囊高位结扎加修补术。结果：全组126例，平均手术时间12min，无一例出现并发症。结论：此方法有切口小、时间短、创伤轻、恢复快、费用低、疤痕不明显等优点，值得推广。     

面斜裂整形修复中泪道重建术的探讨

为了解决面斜裂整形修复中泪道重建的难题，１９８９年３月～１９９５年１月，对４例患者治疗中设计了三种手术方法：泪小管鼻腔吻合术；静脉血管或口腔粘膜移植重建泪道术；改良的泪囊鼻腔吻合术。术后重建的泪道置入导管３～６个月。经术后６个月～１年的观察，面部畸形整复，溢泪消失，红汞试验及泪道检查均通畅，效果满意。认为，应根据泪道畸形程度的不同，选择合适的手术方法，以取得最佳疗效。