基于随机对照试验分析针刺治疗冠心病的临床选穴特点

目的：回顾既往相关随机对照试验文献,分析针刺有效治疗冠心病病例的临床选穴特点。方法：检索2010年1月1日至2020年10月1日公开发表的针刺有效治疗冠心病的随机对照试验文献,并进行回顾性分析,对腧穴选择、腧穴分布、经脉归属、选穴配伍、针刺方法等进行总结。结果：纳入文献45篇,涉及病例3 866例,治疗冠心病多选择心包经、膀胱经和任脉,选穴以内关、膻中、心俞、足三里、神门等最常用,部位以四肢部为主,特定穴以五腧穴和络穴为主,针刺方法以平补平泻法居多。结论：对基于文献对针刺有效治疗冠心病的选穴特点进行了总结分析,为临床选穴辨治提供了参考和借鉴。     

消化性溃疡的临床治疗

目的介绍消化性溃疡的临床治疗方法、治疗目的和有效的预防措施。方法从消化性溃疡的病因、发病机制和病理出发,以该病的临床表现为基础,根据笔者在临床处理中的经验进行总结。结果提出了在临床中治疗消化性溃疡患者时的三种有效方法:①一般治疗方法;②药物治疗方法;③并发症的治疗方法。结论指出了该病的治疗目的和有效的预防措施。     

Redefining affective disorders: relevance for drug development

The evaluation of new drug entities with specific modes of action may be hampered by rigid diagnostic classification systems and patient selection processes that do not focus on the anticipated symptomatic, behavioral, and functional outcomes to be achieved. Patients enrolled in central nervous system (CNS) clinical trials may present with a heterogeneous group of symptoms representing several syndromes or subtypes, subsumed under the same diagnosis in the DSM-IV classification system. As a result, enrolled patients may not have the valid illness characteristics of interest to the particular study. We propose that clinical drug development needs to focus on the primary nosological entity likely to be affected by a new drug entity's mode of action. Ideally, a valid patient will have the acute primary symptoms that the novel drug is supposed to influence. In this article, we propose operational criteria to delineate a more symptom-specific and ecologically valid approach to the identification of the valid patient for clinical trials.     

浅析F30-IIG200mA X线机主可控硅的单向触发

近几年北京万东公司出厂的F30-IIG200mA X线机与以往出厂的该型机器在电路上有所改进,其中高压初级电路由原来接触器控制通断改为由可控硅控制的无触点开关去控制高压初级通断,当可控硅有一路损坏开路或未触发时,使高压初级电流猛增、自耦变压器发出嗡嗡过载负荷声、拍片时厚部位不能穿透,负载时千伏表、电压表数值下跌明显。     

氟罗沙星注射液的细菌内毒素检测方法的实验研究

目的；建立氟罗沙星注射液的细菌内毒素检查法代替其热原检查法，并制订其细菌内毒素限值（L）。方法：用不同的批号，不同生产帮家的鲎试剂，在严格标准操作的条件下，对4批氟罗沙星注射液按有效浓度范围稀释后，进行干扰试验考察。结果：氟罗沙星注射液（10ml:100mg）经4倍衡释后对细菌内毒素检查法无干扰作用。其细菌内毒素限值可定为2.5Eu/ml。结论：对4批氟罗沙星注射液进行了热原检查及细菌内毒素检查的对比试验，两法符合率为100％。     

Reliability and validity of the family satisfaction instrument in families of children with pneumonia

Objective

Family satisfaction has become an integral part of quality of care in hospitals. Thus, it is crucial to develop instruments that measure family satisfaction. The purpose of this study was to examine the validity and reliability of a family satisfaction questionnaire. Method: This study used a survey questionnaire consisting of 26 items that identified nurses' constructs of behaviors and communication. The population surveyed were families whose children were hospitalized due to pneumonia.

一种二维电泳凝胶图像蛋白点数据量化和质量控制的新方法

利用计算机图像处理技术对二维电泳生成簟凝胶图像进行自动分析,是近年图像处理理论在生命科学中的一个重要应用方向,其目的是快速而准确的为病理、药理等生命学科的深入研究提供量化依据。本研究基于数据处理有关理论,提出一整套蛋白点数据量化和质量控制的新算法。实验证明,该算法计算结果准确、可靠,运算速度快,具有一定的抗噪能力。     

Intra- and Inter-Observer Reproducibility of a 2-D Shear Wave Elastography Technique and the Impact of Ultrasound Experience in Achieving Reliable Data

The aim of the study described here was to evaluate the reproducibility of a new shear-wave elastography (SWE) technique, 2-D SWE.GE, and the impact of ultrasound experience in acquiring reliable measurements, as no official recommendations are available for this system. Elastographic measurements (EMs) were obtained in 60 patients using 2-D-SWE with the GE Logiq E9. Three examiners with different levels of experience in ultrasound-based elastography performed 10 valid EMs on each subject: a novice (C.P.) who had no experience in liver elastography and had performed fewer than 50 ultrasound examinations; an elastography expert (A.M.S.) who had more than 1 y of liver elastographic experience in four elastographic methods and had performed more than 1000 ultrasonography examinations; and an ultrasound expert (T.M.) who had no experience in liver elastography and had performed more than 1000 ultrasound examinations. Medians and interquartile ranges were calculated (m/s). We used the inter-class correlation coefficient and Bland–Altman plots with 95% lower and upper limits of agreement to assess the inter- and intra-observer reproducibility of 2-D-SWE.GE measurements. The final study group included 60 patients, 56.7% women and 43.3% men, with a mean age of 33.08?±?13.83 y and mean body mass index of 22.85?±?4.04?kg/m². In this group, 73.3% were healthy volunteers and 26.7% had compensated liver cirrhosis. We did not find significant differences between EMs taken by the examiners overall and across study groups. The overall agreement between examiners was excellent: 0.915 (95% confidence interval [CI]: 0.870–0.946). The agreement between the novice and the experienced examiners, respectively, was good to excellent (novice and ultrasound expert: 0.908, 95% CI: 0.846–0.945; novice and elastography expert: 0.885, 95% CI: 0.808–0.931). The intra-observer reproducibility for each of the examiners was excellent; however, the inter-class correlation coefficients were higher for the examiners more experienced in elastography: 0.936 (95% CI: 0.896–0.963) versus 0.966 (95% CI: 0.943–0.980) versus 0.984 (95% CI: 0. 973–0.991). The good ICCs for the median values indicate that 2-D-SWE.GE is a reproducible method. Ultrasound experience did not significantly influence the results.