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Takahiro Nishio Kojiro Taura Naohiko Nakamura Satoru Seo Kentaro Yasuchika Toshimi Kaido Hideaki Okajima Etsuro Hatano Shinji Uemoto 《Surgery》2018,163(2):264-269
Background
Statins have been reported to reduce the risk of hepatocellular carcinoma (HCC). The effect of perioperative statin use on the prognosis of HCC patients undergoing liver resection remains unclear.Methods
We retrospectively analyzed 643 patients who underwent curative liver resection for HCC. Patients negative for hepatitis B surface antigen and hepatitis C antibody were classified as the non-B non-C HCC subgroup (n?=?204). Perioperative statin users were defined as patients preoperatively receiving statin medications and maintaining?>?28 cumulative defined daily doses after liver resection. The recurrence-free survival (RFS) and overall survival (OS) according to statin use were analyzed in the overall HCC cohort or in the non-B non-C HCC subgroup.Results
Among a total of 643 (HCC) patients, 43 patients (6.7%) received perioperative statin medications. In statin users, the proportion of non-B non-C HCC patients was significantly higher than in nonstatin users. Statin users had a high prevalence of obesity and diabetes, as well as dyslipidemia. The liver function of statin users was better than that of nonstatin users. The multivariate survival analysis revealed that use of statins was significantly associated with improvement of RFS (hazard ratio [HR], .42; 95% confidence interval [CI], 0.25–0.71; P?=?.001), but not with OS (HR, 0.62; 95% CI, 0.30–1.27; P?=?.19). In the subgroup analysis of the non-B non-C HCC cohort, statin use was significantly associated with improvement of RFS (HR, 0.47; 95% CI, 0.22–0.99; P?=?.04).Conclusion
Perioperative statin use was associated with an improvement of RFS in HCC patients undergoing curative liver resection. 相似文献2.
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Ryusuke Murakami Noriomi Matsumura J.B. Brown Koichiro Higasa Takanobu Tsutsumi Mayumi Kamada Hisham Abou-Taleb Yuko Hosoe Sachiko Kitamura Ken Yamaguchi Kaoru Abiko Junzo Hamanishi Tsukasa Baba Masafumi Koshiyama Yasushi Okuno Ryo Yamada Fumihiko Matsuda Ikuo Konishi Masaki Mandai 《The American journal of pathology》2017,187(10):2246-2258
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Kunihisa Miwa MD Hirofumi Kambara MD Chuichi Kawai MD FACC 《The American journal of cardiology》1981,47(6):1210-1214
The effects of aspirin (4.0 g/day) given orally to eight patients with variant angina were observed. An exercise stress test performed in the morning was positive in two of seven patients during placebo administration, whereas a test performed in the afternoon at the same exercise work load resulted in negative findings. During aspirin administration, the afternoon exercise test repeatedly provoked anginal attacks associated with electrocardiographic changes (S-T segment elevation in five and S-T depression in two). Rate-pressure product at the end of the exercise test during aspirin administration was significantly lower than that during placebo administration (p <0.01). During aspirin administration, the frequency of angina increased markedly, and the attacks occurred not only during the night or early morning but also in the daytime in six of the eight patients. Our observations suggest that aspirin, in this large dose, reduces the capacity for exercise and provokes exercise-induced coronary arterial spasm in patients with variant angina. 相似文献
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Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (noninsulin-dependent) diabetes 总被引：3，自引：0，他引：3
H Ishida Y Seino S Matsukura M Ikeda M Yawata G Yamashita S Ishizuka H Imura 《Metabolism: clinical and experimental》1985,34(9):797-801
The degree of diabetic osteopenia and serum vitamin D metabolite levels were measured in 168 type 2 (noninsulin-dependent) diabetic patients. Based on six indices obtained by microdensitometry, we found the bone mass in 26.2% of diabetic patients to be clearly decreased and in 11.9% to be severely decreased. Our direct method of analysis of bone mass shows that diabetic osteopenia differs from typical osteoporosis in character. In addition, serum 24,25-dihydroxyvitamin D was significantly decreased (P less than 0.01), but 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were similar to those of controls. 相似文献
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