环指屈肌腱损伤吻接术前、后力学性能测试研究

研究正常环指屈肌腱拉伸力学性能和模拟屈肌腱损伤后吻接术后屈肌腱的力学性能,为临床提供生物力学参数。取10个手环指标本,解剖后暴露环指,将标本固定于电子万能试验机底座上,由钢丝绳吊钩沿屈肌腱纵行方向钩住、钢丝绳上端固定于试验机上夹头上,驱动机器,对标本进行拉伸实验,施加拉应力,直至屈肌腱断裂。对断裂后的屈肌腱模拟临床手术进行移位吻接,对10个标本做了腱与腱移位吻接。再对吻接后的标本进行拉伸实验。分别得出了正常组标本和吻接术后标本的拉伸最大载荷、应力、应变等数据。表明:屈肌腱腱与腱吻合组最大载荷、应力、应变均小于正常对照组,但模拟末端编织法吻接术腱与腱吻合组标本,仍具有较好的拉伸力学性能指标。     

Gadolinium ring enhancement and mass effect in acute disseminated encephalomyelitis

A 9-year-old boy presented with a subacute history of optic neuritis followed by brainstem involvement, with fever and a lymphocytic pleocytosis in the cerebrospinal fluid. Gadolinium-enhancing ring lesions were demonstrate in the white matter of the cerebrum, brainstem and cerebellum on day 17 of the illness, all appearing simultaneously as part of a monophasic illness. A parietal lesion exerted mass effect. Needling and biopsy yielded no evidence of a pyogenic lesion, tumour or tuberculosis and showed vasculitis. There was insufficient material for myelin staining. Dexamethasone therapy lead to rapid improvement of the radiological lesions: MRI and CT on day 34 of the illness showed complete clearing of the lesions except for residual abnormality at the biopsy site.     

Computed tomographic findings in cerebral toxoplasmosis in adults

The clinical and computerized tomographic (CT) findings in 10 patients with cerebral toxoplasmosis are reviewed. All patients with cerebral toxoplasmosis were homosexuals and/or intravenous drug users, and all patients had other manifestations of AIDS. Two presented with focal seizures, 4 presented with focal neurological deficit which progressively worsened, and 4 had evidence of diffuse neurological dysfunction (altered consciousness, generalized seizures). CT showed a single lesion in 3 patients and multiple lesions in 7 patients. Two patients had hypodense nonenhancing lesions(s). Eight patients had hypodense lesions with peripheral or nodular enhancement. The lesions were more commonly located in the cerebral hemispheres and subcortical gray matter nuclear masses (thalamus, basal ganglia). The finding of a hypodense lesion with a central slightly hyperdense noncalcified region that showed dense nodular homogeneous enhancement was quite characteristic of cerebral toxoplasmosis, but this pattern may also be seen in other neurological conditions including brain lymphomas.     

Cystic lumbar meningioma presenting as a ring enhancing lesion on MRI

We report a cystic lumbar meningioma which presented as a ring enhancing lesion on MRI.     

Case report of de novo dup(18p)/del(18q) and r(18) mosaicism

This is a report of a 27-year-old woman with an unusual de novo chromosomal abnormality. Mosaicism was identified in peripheral blood cells examined by standard G-bands by trypsin using Giemsa (GTG) analysis and fluorescence in situ hybridization (FISH) analysis with chromosome-18 region-specific probes, 46,XX,del(18)(pter → q21.33:)[41], 46,XX,r(18)(::p11.21 → q21.33::)[8], and 46,XX,der(18)(pter → q21.33::p11.21 → pter)[1]. On the other hand, the karyotype of periodontal ligament fibroblasts was nonmosaic, 46,XX, der(18)(pter → q21.33::p11.21 → pter)[50]. All cell lines appeared to be missing a portion of 18q (q21.33 → qter). The pattern of the dup(18p)/del(18q) in the rod configuration raises the possibility of an inversion in chromosome 18 in one of the parents. However, no chromosomal anomaly was detected in either parent. The most probable explanation is that de novo rod and ring configurations arose simultaneously from an intrachromosomal exchange. The unique phenotype of this patient, which included primary hypothyroidism and primary hypogonadism, is discussed in relation to her karyotype.     

High incidence of horse serum protein allergy in various autoimmune disorders.

In 186 persons (68 patients suffering from different so-called autoimmune diseases, 30 kidney recipients, 38 control patients from a surgical ward, and 50 healthy volunteers) the immune response to horse IgG was examined. The lowest rate of sensitization was found in kidney transplant recipients (3%) and the highest in autoimmune patients (33%). After excluding 39 patient who had received horse serum treatment prior to the examination, it was found that without previous injection of horse serum, 27% of the patients with autoimmune disease were sensitized to horse IgG. Compared to the other groups (kidney transplant recipients, 4%: surgical controls, 0%; healthy volunteers, 3%), this difference was statistically significant (p is less than 0.01).     

Influence of pinealectomy and photoperiod on courtship and nest-building in male doves

Sham-operated male doves displayed greater nesting activity under long days (16L:8D) than under short days (8L:16D). This difference was abolished by pinealectomy—the activity of long-day pinealectomized birds dropped to a level comparable to that seen on short days. Removal of the pineal had no effect under the short photoperiod. These results are not due to changes in peripheral androgen production as castrated, testosterone-implanted males also exhibited higher levels of nest-building on long days if sham-operated, but not if they were pinealectomized. Neither treatment had a significant effect on courtship or copulatory behavior. It is suggested that the pineal mediates the stimulatory effect of long photoperiods on hormonally-induced nest-building in doves.     

黄体生成素释放激素免疫反应神经元在环鸽脑中分布的研究

应用免疫组织化学方法，研究了环鸽（Ｓｔｒｅｐｔｏｐｅｌｉａｒｉｓｏｒｉａ）脑中ＬＨＲＨ－ＩＲ细胞的分布。结果表明：黄体生成素释放激素（ＬＨＲＨ）免疫阳性细胞主要分布在前连合（ＣＡ）背内侧和腹内侧、下丘脑外侧核（ＬＨｙ）、内侧隔核（ＳＭ）腹内侧、内视前核（ＰＯＭ）区和前视前核（ＰＯＡ）区。ＬＨＲＨ免疫反应细胞分布的中心位于ＰＯＡ。由于下丘脑一些脑区与鸟类控制发声和听觉脑区存在直接神经纤维连系，这些结果为鸟类听觉、发声和内分泌脑区相互作用机理的研究提供了新的形态学依据     

鸽中脑半圆隆枕传出投射的研究

应用ＰＨＡ－Ｌ和Ｂｉｏｃｙｔｉｎ两种神经示踪物对非鸣禽环鸽（Ｓｔｒｅｐｔｏｐｅｌｉａｒｉｓｏｒｉａ）中脑半圆隆枕（ｔｏｒｕｓｓｅｍｉｃｉｒｃｕｌａｒｉｓ）的传出投射进行了分区研究。结果发现半圆隆枕丘间核内缘（ＩＣＭ）发出两束纤维分别向尾端投射至外侧丘系背核腹侧（ＬＬＤｖ）周围和向首端投射至丘脑卵形壳（Ｏｖ－ｓｈｅｌｌ）；丘间核（ＩＣｏ）发出的纤维直接投射至下丘脑前内侧核（ＡＭ）。从脑桥至听丘各级听神经核周围，均存在疏松网状神经纤维结构区，它们相互连接形成了一条与经典听觉神经通路相平行的旁听觉神经通路。这是首次关于鸟类发声、听觉和内分泌三维系统存在直接神经环路联系的较为完正的报道。