首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   398篇
  免费   10篇
  国内免费   4篇
耳鼻咽喉   1篇
儿科学   5篇
妇产科学   5篇
基础医学   45篇
口腔科学   7篇
临床医学   31篇
内科学   70篇
皮肤病学   3篇
神经病学   10篇
特种医学   21篇
外科学   151篇
综合类   11篇
预防医学   11篇
眼科学   9篇
药学   18篇
中国医学   6篇
肿瘤学   8篇
  2023年   10篇
  2022年   15篇
  2021年   21篇
  2020年   12篇
  2019年   61篇
  2018年   54篇
  2017年   40篇
  2016年   7篇
  2015年   9篇
  2014年   14篇
  2013年   32篇
  2012年   8篇
  2011年   9篇
  2010年   1篇
  2009年   8篇
  2008年   6篇
  2007年   3篇
  2006年   4篇
  2005年   5篇
  2000年   2篇
  1999年   1篇
  1997年   1篇
  1995年   1篇
  1991年   1篇
  1987年   1篇
  1985年   7篇
  1984年   12篇
  1983年   9篇
  1982年   9篇
  1981年   3篇
  1980年   7篇
  1979年   9篇
  1978年   6篇
  1977年   5篇
  1976年   4篇
  1975年   8篇
  1974年   3篇
  1973年   4篇
排序方式: 共有412条查询结果,搜索用时 15 毫秒
1.
2.

Background

One daily dose of tacrolimus (QDT) improves adherence in kidney transplant (KT) recipients. A switch from twice-daily tacrolimus (BDT) to QDT showed similar efficacy and safety.

Methods

The aim of our study was to demonstrate the long-term efficacy and safety of switching from BDT to QDT in KT recipients. Preliminary results have already been published. Forty-one patients (34 men and 7 women), mean age at KT of 43.9 ± 12.7 years, underwent a 1:1 dose switch from BDT to QDT; the mean time from KT to switch was 36.6 ± 16.1 months. In our study population, 4 patients received a living donor KT and 2 received a second allograft.

Results

The mean follow-up was 86.8 ± 13 months from the switch and 126.2 ± 22.3 months from KT. Graft and patient survival rates were 90.2% and 95.1%, respectively. All patients maintained stable renal function during follow-up. During the first 3 months after the switch we observed a significant decrease in tacrolimus blood level (P = .0001). No significant differences were observed regarding tacrolimus dose before and after QDT introduction (P = not significant [NS]). Fourteen patients who stopped steroids under BDT treatment and 16 patients who stopped steroids after the switch are currently steroid-free.

Conclusion

Our study showed safety and efficacy in switching from BDT to QDT. After early (<1 year) dose adjustment, tacrolimus blood levels remained stable throughout follow-up. Moreover, QDT represented a valid alternative for patients showing steroid side effects.  相似文献   
3.
4.
《Substance use & misuse》2013,48(3):301-311
Sober living houses’ are alcohol- and drug-free residences for individuals attempting to establish or maintain sobriety. They offer no formal treatment services but do provide social support and an abstinent living environment. ‘Sober living houses’ have been used as aftercare placements for clients completing residential treatment, places for clients to live while attending outpatient treatment, or as stand-alone approaches for substance misuse problems. This article identifies areas of research needing attention and suggests that ‘sober living houses’ have the potential to play a stronger role in the continuum of substance misuse services.  相似文献   
5.
6.
7.
Research indicates that Latinos underutilize substance abuse interventions; cultural variables may contribute to difficulties accessing and completing treatment for this group. As a result, there is a need to understand the role of cultural constructs in treatment outcomes. The purpose of this study was to investigate how levels of collectivism (COL) and individualism (IND) relate to length of stay and relapse outcomes in self-run recovery homes. We compared Latinos in several culturally modified recovery Oxford Houses to Latinos in traditional recovery Oxford Houses. By examining COL and IND in the OH model, we explored whether aspects of COL and IND led to longer lengths of stay and better substance use outcomes. We hypothesized that higher levels of COL would predict longer stays in an Oxford House and less relapse. COL did not have a main effect on length of stay. However, COL had a significant interaction effect with house type such that COL was positively correlated with length of stay in traditional houses and negatively correlated with length of stay in the culturally modified condition; that is, those with higher collectivism tended to stay longer in traditional houses. When we investigated COL, length of stay, and substance use, COL was negatively correlated with relapse in the culturally modified houses and positively correlated with relapse in the traditional houses. In other words, those with higher COL spent less time and had less relapse in the culturally modified compared to the traditional Oxford Houses. The implications of these findings are discussed.  相似文献   
8.
9.
Two Way Prayer formed an essential part of Oxford Group and early Alcoholics Anonymous (AA) spiritual practices. Pioneer AA members considered it more essential for recovery than attendance at meetings; however, it was gradually lost as a component of contemporary 12-Step programs. The article gives an overview of its history and provides a model for a more contemporary form of its practice. Initial evaluation suggests promising outcomes among a sampling of youth and adults engaged in a peer-support group for drug and alcohol recovery. The article includes a discussion of its use with individuals not having a religious conception of spirituality.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号