Comparative surface thrombogenicity of implanted vascular grafts.

In order to study the comparative thrombogenicity of neointimal surfaces that develop with three types of vascular graft materials (ultralightweight knitted dacron, knitted dacron external velour, and expanded Teflon), 36 female mongrel dogs had their infrarenal aortas alternately replaced with one of the three grafts. At the end of 3 or 6 months, the grafts were removed and the surface thrombogenicity of the neointimal surface was determined. Each graft was examined visually and microscopically for evidence of “healing.” At 6 months the external velour graft is lined more frequently than the other two grafts. The external velour graft has a markedly better incidence of cellular healing noted microscopically than the other two grafts at both time intervals. While the expanded Teflon has an initially lower surface thrombogenicity (probably due to the characteristics of Teflon surface), at 6 months, the velour graft has the lowest surface thrombogenicity. This is most likely due to cellular healing. Of all the completely lined grafts at both time intervals, the surface thrombogenicity of the velour grafts was most like that of the normal aorta. The velour graft appears to develop the least thrombogenic neointimal surface while becoming most frequently healed with a cellular neointimal surface.     

雷公藤、防己醇提物对淋巴细胞和环氧化酶的影响

目的:探讨雷公藤、防己醇提取物对淋巴细胞和环氧化酶的影响.方法:测定两种药物的醇提物引起小鼠胸腺淋巴细胞和脾脏淋巴细胞增殖的变化,新生小公牛颈动脉内皮细胞的6-keto-PGF1α和小鼠腹腔巨噬细胞的PGE2含量.结果:雷公藤和防己醇提物对小鼠胸腺淋巴细胞和脾脏淋巴细胞的增殖有抑制作用.雷公藤醇提物对环氧化酶-1(COX-1)和环氧化酶-2(COX-2)有不同程度的抑制作用.防己醇提物对COX-1有抑制作用,而对COX-2无抑制作用.结论:两种药物的祛风湿的部分机理可能是由于抑制淋巴细胞增殖和环氧化酶而介导的.     

Late Results of Perthes' Disease

A follow-up is given of early and late results in 109 arthroplasties with the self-locking Austin T. Moore vitallium femoral head prosthesis in fractures of the femoral neck on 106 patients. Operative indication was usually fresh medial fracture of the femoral neck in an elderly woman, or its late complication. The surgery was performed in a unit for general surgery also engaged in pre- and postgraduate teaching activities. Many operations were performed by residents engaged in general surgery or orthopaedics. Point scores according to a modification of Merle D'Aubigné's classification showed excellent or at least good results in 81 per cent of the 69 mobile patients. Because of deteriorated general physical condition 11 patients were chronically bed-ridden. Five patients could not be reached. In three instances the prosthesis was removed. 21 patients died, three during the stay in hospital and 18 later for reasons not connected with the operative procedure. The mortality during 40 months of observation corresponded fairly well to that expected in the age group for the population as a whole.     

Electrophysiologic properties of a new antiarrhythmic drug--tocainide

Tocainide (Astra W36095) is an orally active antiarrhythmic drug that is structurally related to lidocaine. This paper describes in vivo and in vitro studies undertaken to assay the electrophysiologic properties of this compound. Ouabain-induced ventricular ectopic activity was abolished by this drug in both isolated canine Purkinje fibers and in intact dogs. Similarly, the ventricular ectopic activity that occurs 24 hours after the two stage Harris coronary arterial ligation procedure also was abolished by tocainide. The amount of current necessary to evoke an action potential by intracell stimulation during diastole was Increased in direct relation to drug concentration. Similarly, in dogs anesthetized with pentobarbital sodium, tocainide increased the ventricular fibrillation threshold up to 150 percent above control values during normal supraventricular rhythm and up to 285 percent after premature ventricular beats. The transmembrane action potential duration and effective refractory period of isolated canine Purkinje fibers were shortened by tocainide. Tocainide depressed atrioventricular nodal conduction in anesthetized dogs, an effect that was magnified in the presence of premature atrial beats but had no effect on His, Purkinje or ventricular muscle conduction. These results Indicate that tocainide is a potentially effective antiarrhythmic agent and deserves further investigation in patients.     

Disparities by Sex Tracked in the 2015 National Healthcare Quality and Disparities Report: Trends across National Quality Strategy Priorities,Health Conditions,and Access Measures

Introduction

Established by the Affordable Care Act, the National Quality Strategy (NQS) is the national policy goals aimed at improving the quality of health care for all Americans. The NQS established six priorities to provide better, more affordable care for individuals and communities. This is the first analysis of data on the NQS and access measures that focus on sex differences, health conditions, trends, and disparities.

正交试验优选防己中粉防己碱和防己诺林碱的提取工艺

目的优选防己中粉防己碱和防己诺林碱的最佳提取工艺。方法以总生物碱的含量和浸膏的率为考察指标,采用正交试验,考察提取溶媒的浓度、提取时间、提取次数和提取溶媒的用量对提取的影响,确定了防己中粉防己碱和防己诺林碱的最佳提取工艺。结果最佳提取工艺条件是：以6倍量60%乙醇提取3次,每次1小时。结论优选得到的提取工艺得率高,操作简便易行。     

防己对胸腺细胞作用的研究

目的研究防己（Stepheniatetrandra SMoore）对小鼠胸腺的细胞DNA的影响及其作用机制。方法取小鼠胸腺的细胞,随机分为对照组和药物组,药物组又再分为两组（防己煎剂浓度分别为10μg／ml,100μg/ml）,采用DNA凝胶电泳观察其对小鼠胸腺细胞的作用。结果防己煎剂（10μg／ml、100μg／ml）对胸腺的细胞分别处理12h后,可见典型的DNA梯形条带。结论防己煎剂可诱导小鼠胸腺的细胞凋亡。