全文获取类型
收费全文 | 155篇 |
免费 | 8篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 5篇 |
妇产科学 | 1篇 |
基础医学 | 3篇 |
临床医学 | 9篇 |
内科学 | 21篇 |
皮肤病学 | 2篇 |
特种医学 | 21篇 |
外科学 | 50篇 |
综合类 | 14篇 |
预防医学 | 5篇 |
药学 | 13篇 |
中国医学 | 6篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 2篇 |
2021年 | 7篇 |
2020年 | 9篇 |
2019年 | 15篇 |
2018年 | 9篇 |
2017年 | 7篇 |
2016年 | 5篇 |
2015年 | 2篇 |
2014年 | 16篇 |
2013年 | 8篇 |
2012年 | 8篇 |
2011年 | 13篇 |
2010年 | 9篇 |
2009年 | 9篇 |
2008年 | 8篇 |
2007年 | 5篇 |
2006年 | 7篇 |
2005年 | 4篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 1篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1994年 | 1篇 |
排序方式: 共有164条查询结果,搜索用时 31 毫秒
1.
H. Seyer J. Honegger W. Schott M. Küchle W. J. Huk R. Fahlbusch H. Frisch 《Acta neurochirurgica》1994,131(1-2):157-159
Summary Inferior petrosal sinus sampling (IPSS) is used to evaluate the pituitary-dependency of Cushing's disease, and to predict the laterality of a microadenoma prior to transsphenoidal operation. A serious complication occured in a 14-year-old boy: he suffered brain stem ischaemia with abducens nerve palsy and hemiparesis (Raymond's syndrome). The case prompted us to reconsider the indication for this investigation. 相似文献
2.
3.
Canan Alhan Theresia M. Westers Eline M. P. Cremers Claudia Cali Birgit I. Witte Gert J. Ossenkoppele Arjan A. van de Loosdrecht 《British journal of haematology》2014,167(1):100-109
The estimation of survival of myelodysplastic syndromes (MDS) and risk of progression into acute myeloid leukaemia is challenging due to the heterogeneous clinical course. The most widely used prognostic scoring system (International Prognostic Scoring System [IPSS]) was recently revised (IPSS‐R). The aim of this study was to investigate the prognostic relevance of flow cytometry (FC) in the context of the IPSS‐R. Bone marrow aspirates were analysed by FC in 159 patients with MDS. A flow score was calculated by applying the flow cytometric scoring system (FCSS). Patients were assigned to IPSS and IPSS‐R risk groups. The FCSS correlated with the World Health Organization classification, IPSS and IPSS‐R risk groups. Mild flow cytometric abnormalities were associated with significantly better overall survival (OS) and lower risk of disease evolution. The presence of aberrant myeloid progenitors was associated with transfusion dependency and disease progression. Most importantly, the FCSS identified prognostic subgroups within the IPSS‐R cytogenetic good risk and low risk group. Flow cytometric analysis in patients with MDS provides additional prognostic information and is complementary to the IPSS‐R. The addition of a flow cytometric score next to the clinical parameters within the IPSS‐R is a further refinement of prognostication of patients with MDS. 相似文献
4.
Bruno Deltreggia Benites Carolina Silva Costa Lima Irene Lorand-Metze Marcia Torresan Delamain Gislaine Borba Oliveira Daiane de Almeida Carmino Antonio de Souza Jose Vassallo Katia Borgia Barbosa Pagnano 《Clinics (S?o Paulo, Brazil)》2013,68(3):339-343
OBJECTIVES:
To evaluate whether risk scores used to classify patients with primary myelofibrosis and JAK-2 V617F mutation status can predict clinical outcome.METHODS:
A review of clinical and laboratory data from 74 patients with primary myelofibrosis diagnosed between 1992 and 2011. The IPSS and Lille scores were calculated for risk stratification and correlated with overall survival.RESULTS:
A V617F JAK2 mutation was detected in 32 cases (47%), with no significant correlation with overall survival. The patients were classified according to the scores: Lille - low, 53 (73.%); intermediate, 13 (18%); and high, 5 (7%); and IPSS – low, 15 (26%); intermediate-1, 23 (32%); intermediate-2, 19 (26%); and high, 15 (31%). Those patients presenting a higher risk according to the IPSS (high and intermediate-2) had a significantly shorter overall survival relative to the low risk groups (intermediate-1 and low) (p = 0.02).CONCLUSIONS:
These results emphasize the importance of the IPSS prognostic score for risk assessment in predicting the clinical outcome of primary myelofibrosis patients. 相似文献5.
Tobias Franiel René Aschenbach Sarah Trupp Thomas Lehmann Friedrich-Carl von Rundstedt Marc-Oliver Grimm Ulf Teichgräber 《Journal of vascular and interventional radiology : JVIR》2018,29(8):1127-1137
Purpose
To evaluate clinical outcomes and possible MR imaging predictors of clinical success after prostatic artery embolization (PAE) with 250-μm hydrogel particles.Materials and Methods
During a span of 1.5 years, 30 patients with moderate to severe lower urinary tract symptoms were included in a prospective, nonrandomized study. Embolization of at least one prostatic artery was considered as technical success. International Prostate Symptom Score (IPSS), quality of life (QOL), peak urinary flow rate (Qmax), residual urine volume, prostate volume, prostate-specific antigen level, and International Index of Erectile Function (IIEF) were recorded at baseline and at 1, 3, and 6 months after PAE. Multiparametric MR imaging was performed before PAE (n = 25) and 1 day (n = 25), 1 month (n = 7), 3 months (n = 7), and 6 months (n = 22) after intervention. A Wilcoxon–Mann–Whitney test was used to assess changes over time, and Spearman rank-correlation coefficient was used for outcome prediction.Results
PAE was technically successful in 90% of patients (n = 27). Clinical success (IPSS < 18 with decrease > 25% and QOL score < 4 with decrease ≥ 1 or Qmax ≥ 15 mL/s and increase of ≥ 3.0 mL/s) rates were 59% (16 of 27), 63% (17 of 27), and 74% (20 of 27) after 1, 3, and 6 mo, respectively. IIEF scores did not differ significantly during follow-up. The following adverse events occurred after PAE: urethral burning (5 of 27), fever (2 of 27), and urethral bleeding, rectal bleeding, cystitis, and penile burning sensation (1 of 27 each). No statistical correlations between initial multiparametric MR imaging changes and clinical parameters after 6 months were found (P values from .14 to .98).Conclusions
PAE with 250-μm hydrogel microspheres led to good clinical success after 6 months with a low complication rate. Significant MR imaging predictors of clinical success were not identified. 相似文献6.
目的 测定原位肝移植大鼠移植肝肝内门-体分流量的变化。方法健康清洁级封闭群雄性SD大鼠,分为供体组和受体组,采用简化二袖套法建立大鼠原位肝移植模型(rat orthotopic liver transplantation model。ROLTM)24只,分为移植后2h、4d、7d三组,每组8只。各组于相应时间点进行肝脏活体在体灌注。经小隐静脉插管连续灌注D-山梨醇,同时取门静脉和肝静脉血,用酶分光光度法测定山梨醇浓度,计算肝内门-体分流量。结果2h、4d、7d组肝内门-体分流量分别为39.9%,52.3%,27.6%,组间差异显著,且均比正常大鼠明显增高。结论 ROLTM大鼠移植肝血供恢复后即存在肝内门-体分流,并随时间推移分流量变化呈先增加后减少的过程。 相似文献
7.
Başar MM Yilmaz E Ferhat M Başar H Batislam E 《International urology and nephrology》2005,37(4):773-777
Aim: The aim of the present study was to evaluate the efficacy of terazosine in patients with premature ejaculation and lower
urinary tract symptoms (LUTS), after excluding other sexual disorders and chronic prostatitis. Methods: A total of 90 patients with premature ejaculation and LUTS were enrolled to the study after excluding sexual disorders,
prostatitis and benign prostatic hyperplasia. The patients were divided into two groups. Sixty patients in group 1 were treated
with terazosine 5 mg daily for a month. Patients were followed monthly and questioned for their ejaculation problem. The results
were classified as cure, improvement and ineffective. If patients showed improvement and ineffectiveness, the treatment was
continued with 10 mg daily for the following month. Group 2 was included 30 patients, and placebo was applied for a month.
At the end of this period, in patients who did not show any improvement, terazosine 10 mg was started. Results: In the treatment group, at the 1st month follow-up, 21 patients (35%) were cured, 20 (33.3%) showed improvement. In 19 (31.7%)
patients, the treatment was ineffective. In group 2, 9 (30%) patients showed improvement and the rest had no-changes after
one-month follow up. There was statistically significant difference between two groups (Pearson χ2 test=0.000). Later, terazosine 10 mg was given to the patients in group 2 and to the patients who showed improvement or unsuccessful
result with terazosine 5 mg. With terazosine 10 mg, 10 (14.5%) patients were cured, 29 (42.2%) patients were improved. Finally,
terazosine treatment in patients with premature ejaculation was found to be effective in 60 patients (66.7%).Conclusion: Alpha blockers seem to be physiological medical agents in the treatment of premature ejaculation since ejaculation is under
sympathetic control. Moreover, these agents are effective in lower urinary tract and they should be used in patients with
premature ejaculation and lower urinary tract symptoms. 相似文献
8.
AIM: To study the correlation between non-invasive urodynamic data, the International Prostate Symptom Score (IPSS) and the prostate volume. MATERIALS AND METHODS: Data of 667 healthy volunteers participating in a longitudinal study of changes in urinary bladder contractility secondary to BPE were analyzed. The prostate volume was assessed by transabdominal ultrasonography. Uroflowmetry followed to verify if a minimum free flow rate of 4.5 ml/sec could be achieved. While (re)filling the bladder by drinking, the subjects completed the Dutch version of the IPSS. Next, the bladder pressure was non-invasively measured using the condom catheter method. The urethral resistance (URR) was calculated from the maximum condom pressure and the maximum free flow rate. RESULTS: The IPSS ranged from 0 to 29, (6.1 +/- 4.8) (mean +/- SD), whereas the prostate volumes ranged from 8 to 140 cm3, (34 +/- 18). Twenty eight percent (185/667) of the subjects had a non-invasively quantified high URR and a significantly higher IPSS (7.3 +/- 5.2) than those with a low URR (IPSS (5.7 +/- 4.6)), Mann-Whitney U-test: P < 0.001. The IPSS and the URR were significantly correlated, Spearman's rho (rho) = 0.20, P < 0.001. A significant difference between the prostate volumes, 36 +/- 21 cm3 in the high URR versus 33 +/- 17 cm3 in the low URR group, was not found, P = 0.18. CONCLUSIONS: A weak though statistically significant correlation was found between the non-invasively quantified URR and the IPSS. This suggests that an elevated resistance is a necessary, but not a sufficient condition for lower urinary tract symptoms (LUTS). No correlation was found between the URR and the prostate volume. 相似文献
9.
Zaker I. Schwabkey Najla Al Ali Onyee Chan David A. Sallman Eric Padron Andrew T. Kuykendall Chetasi Talati Kendra Sweet Jeffrey E. Lancet Rami S. Komrokji 《Clinical Lymphoma, Myeloma & Leukemia》2021,21(1):e52-e56
BackgroundCytogenetic profile is an essential parameter in myelodysplastic syndromes (MDS) risk stratification by both International Prognostic Symptom Score (IPSS) and Revised (R)-IPSS. Almost one-half of patients with MDS have normal cytogenetics by metaphase karyotype. Here we report the yield of MDS fluorescence in situ hybridization (FISH) panel detecting cytogenetic abnormalities in these patients and its impact on risk stratification.Patients and MethodsAmong patients with normal metaphase karyotype, we assessed those patients who had cytogenetic abnormalities detected by an MDS FISH panel, which included probes for del (5), del (7), del (20), trisomy 8, and del (17p). Risk stratification was calculated by both IPSS and R-IPSS.ResultsOf 1600 patients with MDS with normal metaphase karyotype, 53 (3%) patients had cytogenetic abnormality detected by MDS FISH panel. Integrating the MDS FISH panel cytogenetics (IPSS + FISH restaging) resulted in upstaging the score, where 53% of low-risk IPSS were upstaged to intermediate (int)-1, 56% of int-1 were upstaged to int-2, and 78% of int-2 were upstaged to high risk. Based on the R-IPSS, 61% of very low-risk patients, all low-risk patients, 92% of intermediate-risk patients, and 50% of high-risk patients with FISH abnormalities were upstaged, respectively.ConclusionThe yield of MDS FISH panel detecting cytogenetic abnormalities in patients with normal karyotype by G-banding is low and may not warrant ordering the panel in all patients. Among the 3% of patients with normal karyotype who had cytogenetic abnormality detected by FISH, the risk score assignment by IPSS and R-IPSS was upstaged. 相似文献
10.
目的 观察经尿道前列腺电切术治疗前列腺增生的临床效果.方法 选择我院收治的78例前列腺增生患者为研究对象,采用随机数字表法随机分为对照组和观察组,对照组采用传统开放性手术治疗.观察组采用经尿道前列腺电切术治疗,比较两组治疗前后前列腺增生临床症状改善情况及日常生活质量改善情况.结果 观察组、对照组患者治疗后IPSS评分(7.3±0.7)、(10.2±1.2)显著优于治疗前(15.4±2.1)、(15.3±2.1),差异有统计学意义(P<0.05).观察组患者治疗后IPSS评分改善情况更佳.观察组、对照组患者治疗后生活质量指数(0.5±0.2)、(2.1±0.6)显著优于治疗前(5.2±0.6)、(5.3±0.7),差异有统计学意义(P<0.05).观察组患者治疗后生活质量改善情况更佳.观察组患者治疗后残余尿量(19.3±4.3)mL及最大尿流率(12.9±2.5)mL/s改善显著优于对照组(50.1±4.5)mL、(10.9±2.3)mL/s,差异有统计学意义(P<0.05).结论 采用经尿道前列腺电切术治疗前列腺增生疗效显著,安全性好,可显著提高患者生活质量,值得临床推广应用. 相似文献