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排序方式: 共有398条查询结果,搜索用时 0 毫秒
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Dedifferentiated chondrosarcoma 总被引:2,自引:0,他引:2
M. Mercuri M.D. P. Picci M.D. L. Campanacci M.D. E. Rulli M.D. 《Skeletal radiology》1995,24(6):409-416
We reviewed 74 cases of dedifferentiated central and peripheral chondrosarcoma. Histologically these tumours consist of an underlying cartilaginous component (either benign or malignant) juxtaposed to a highgrade non-cartilaginous component, with a typically abrupt transition between the two tissue types. The noncartilaginous component may constitute a very small or a very large proportion of the tumour, so diagnosis often requires histological evaluation of the entire tumour. The diagnosis is often suspected on the basis of the clinical course and careful evaluation of the radiographie characteristics. Central dedifferentiated chondrosarcoma can be classified radiographically into three types. In type 1 (36 cases in our review) the radiographie features are the same as those of a central chondrosarcoma, with the addition of a region with very aggressive radiographie features. Type 2 lesions (20 cases) resemble the underlying benign enchondroma but also have destructive changes and/or a large soft tissue mass. Type 3 lesions (8 cases) are not distinctive radiographically and present as a very high grade destructive lesion of bone. These cases are diagnosed following biopsy or tumour resection. The prognosis of these tumours is extremely poor, with 13% overall 5-year survival in this series. Improved survival was found in those cases where diagnosis was prompt and surgical treatment with a wide or radical margin was attained. No benefit was found from the use of adjuvant chemotherapy or radiotherapy. Thus, early recognition of the characteristic radiographie features, adequate histological sampling, and wide or radical surgical margins are necessary for satisfactory management of this highly malignant variant of chondrosarcoma. 相似文献
3.
A 65-year-old male patient with an 8-year history of poliostotic Paget’s disease complained of shoulder pain that started
6 months prior to admission. An extensive lytic area was identified in the right proximal humerus along with Paget’s disease.
There was cortical destruction and a soft tissue mass. Following an incisional biopsy, a diagnosis of grade 2 chondrosarcoma
associated with Paget’s disease was made. The histologic identification of chondrosarcoma associated with Paget’s disease
is rare. However, the presence of a calcified matrix in a destructive lesion associated with Paget’s disease should alert
the radiologist and the pathologist to the possibility of a chondromatous differentiation taking place in the sarcoma associated
with Paget’s disease. The histologic evaluation of the lesion will form the basis for the diagnosis. 相似文献
4.
Aygenc Erdinc Dere Huseyin Ozdem Cafer 《European archives of oto-rhino-laryngology》2003,260(10):555-557
Chondrosarcoma is a rare tumor. In this study, we present a case with laryngeal chondrosarcoma that was treated by an endolaryngeal approach using an operation microscope. The patient remains disease-free to date, with no evidence of new or recurrent disease more than 3 years after the endolaryngeal surgery. The computerized tomography and endoscopic examinations did not reveal any recurrent disease, indicating the success of the endolaryngeal approach. 相似文献
5.
目的评价脊柱软骨肉瘤术后复发cT引导下放射性^125I粒子植入的初步结果。方法采用cT引导放射性125I粒子植入的方法对5例脊柱软骨肉瘤术后复发患者进行治疗,术前应用三维治疗计划系统制定粒子分布计划,术中间距0.5~1.0cm植入粒子,距离危险器官的安全距离大于1.0cm,术后进行质量验证。结果本组平均随访时间15.2个月(2—41个月),局部有效率60.0%。平均局部控制时间11.4个月,1年局部控制率60.0%。平均生存期15.2个月,1年生存率为66.7%。术前和术后NRS评分分别为6.00±2.65分和1.00±1.00分,二者差异有显著性(P值〈O.05),镇痛有效率100.0%。结论CT引导下放射性^125I粒子植入治疗脊柱软骨肉瘤术后复发病例效果确切.疼痛缓解满意,临床应用价值较高。 相似文献
6.
Summary A rare case of cervical chondrosarcoma is presented and its clinical behavior and treatment modalities are discussed. 相似文献
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9.
《Pathology, research and practice》2014,210(12):1095-1099
The differentiation between osteomyelitis and bone tumor may be difficult due to their overlapping clinical and radiological features. A 25-year-old lady presented with left knee pain and joint effusion associated with redness and hotness. A sub-optimally taken plain radiograph showed mixed osteolytic and osteoblastic lesion in the left lower femur with surrounding soft tissue swelling. Since the clinical diagnosis was acute osteomyelitis and arthritis, arthroscopic lavage was performed as a diagnostic and therapeutic procedure. The removed loose bodies and fibrinous tissue showed pathological features suspicious of chondrosarcoma. Subsequent MRI revealed an infiltrative tumor eroding through the cortex and joint cartilage. En bloc excision of the left lower femur, upper tibia including the knee joint and patella was performed, and the final diagnosis was grade 2 chondrosarcoma. The patient developed bilateral pulmonary metastasis 33 months after operation. Five months later, she suffered from a hitherto undescribed complication of ischemic perforation of the terminal ileum secondary to tumor embolic arterial obstruction with no macroscopic intestinal or peritoneal tumor deposit. The patient developed multiple brain metastases and died 43 months after initial presentation.Our case illustrates that malignant bone tumor as a differential diagnosis of acute osteomyelitis and arthritis merits recognition and exclusion before arthroscopic lavage, which may enhance tumor dissemination and in our patient results in embolic ischemic ileal perforation. 相似文献
10.
《Surgical pathology clinics》2017,10(1):223-279
Benign and malignant primary bone and soft tissue lesions of the head and neck are rare. The uncommon nature of these tumors, combined with the complex anatomy of the head and neck, pose diagnostic challenges to pathologists. This article describes the pertinent clinical, radiographic, and pathologic features of selected bone and soft tissue tumors involving the head and neck region, including angiofibroma, glomangiopericytoma, rhabdomyosarcoma, biphenotypic sinonasal sarcoma, chordoma, chondrosarcoma, and osteosarcoma. Emphasis is placed on key diagnostic pitfalls, differential diagnosis, and the importance of correlating clinical and radiographic information, particularly for tumors involving bone. 相似文献