貌似脑瘤的脑型血吸虫病15例临床分析

目的 探讨脑瘤型脑血吸虫病的临床及MRI的特点.方法 对收治的15例脑瘤型脑血吸虫病的临床资料、实验室检查及MRI资料进行回顾性分析.结果 均为慢性脑型血吸虫病肉芽肿型,表现为脑瘤型.脑瘤型脑血吸虫病的MRI表现具有特征性.结论 脑瘤型脑血吸虫病的MRI易误诊为肿瘤,应结合实验室及影像学检查综合分析.     

The characteristics of suicide attempters admitted to the main general hospital in Fiji Islands

Objective: To study the characteristics of suicide attempters attending the main general hospital in Fiji Islands. Method: Consecutive suicide attempters were clinically evaluated, and their sociodemographic and clinical characteristics were compared with those of other patients seen in the psychiatric service between January 15, 1999 and January 14, 2000. Results: Thirty-nine suicide attempters were seen, representing 36.8% of all the cases referred to the psychiatric service. The prevalence of attempted suicide in the Greater Suva Area was 34.8 per 100,000. Majority (56.4%) were young (16–25 years), Indians (59%), female (61.5%), students (41%), never married (74.4%) and of Hindi faith (48.7%). The commonly used methods were ingestion of drugs and pesticides. The intention to die was present in 20 (51.3%) of the population. Social problems and/or psychiatric comorbidity were present in over 60% of cases. Suicide attempters were significantly younger, more of single persons (P<.0001), and fewer were in employment (P<.001) than nonsuicidal cases seen. The difference was not significant when the two groups were compared regarding gender, race or religion. Conclusions: Young people attempt suicide in disturbed psychosocial milieu, using available poisoning methods with strong desire to die. Apparently, high proportion of female Indians in this group reflects high rate of service utilization by them. Unemployment is an insignificant predisposing factor.     

心电波形惟一性探讨

目的研究不同个体之间心电信号的惟一性特征。方法随机挑选100份同步12导联心电图进行描述分析,对比相同点及不同点,将每份心电图的波形特征逐一输入Excel电子表格,按照波形特征顺序进行排序。结果Ⅰ导联共有25例4组重复。在这些重复的病例中:Ⅱ导联共有25例7组重复,Ⅲ导联共有24例8组重复,avR导联共有20例6组重复,avL导联共有3例1组重复,avF导联共有3例1组重复,100例中无任何两例心电波形在12个导联上完全相同。结论心电信号具有生物特征的惟一性,可作为一种新的生物特征识别方法用于身份识别。     

青岛市1990～2003年成人麻疹病例流行病学特征分析

青岛市 1990～ 2 0 0 3年共报告成人麻疹 2 30例 ,年平均报告发病率为 0 30 /10万 ( 0～ 1 17/10万 )。 1997年以前 ,成人麻疹呈散发 ,而 1998年以后发病明显增加 ,1998～ 2 0 0 3年年平均报告发病率为 0 6 0 /10万 ( 0 13/10万～1 17/10万 ) ,与 1990～ 1997年的年平均报告发病率 0 0 7/10万相比 ,上升了 7 5 7倍。发病高峰在每年的 3～ 5月。 71 31%的病例为 18～ 2 4岁 ,196 9年及以后出生人群的发病危险是 196 9年以前出生人群的 19 83倍。外来人口病例占总病例的 4 8 2 6 % ,外资和民营企业的工人 (占 4 4 35 % )、大学生 ( 14 78% )、农民 ( 11 74 % )等是成人麻疹发病的重点人群。外来人口发病是青岛市成人麻疹报告发病率升高的主要因素 ,无麻疹疫苗免疫史、免疫失败是导致成人麻疹发病增高的关键原因。     

OLFM4, LY6D and S100A7 as potent markers for distant metastasis in estrogen receptor‐positive breast carcinoma

Metastatic breast cancer is a highly lethal disease, and it is very important to evaluate the biomarkers associated with distant metastasis. However, molecular features of distant metastasis remain largely unknown in breast cancer. Estrogens play an important role in the progression of breast cancer and the majority of stage IV breast carcinomas express estrogen receptor (ER). Therefore, in this study, we examined molecular markers associated with distant metastasis in ER‐positive breast carcinoma by microarray and immunohistochemistry. When we examined the gene expression profile of ER‐positive stage IV breast carcinoma tissues (n = 7) comparing ER‐positive stage I‐III cases (n = 11) by microarray analysis, we newly identified OLFM4, LY6D and S100A7, which were closely associated with the distant metastasis. Subsequently, we performed immunohistochemistry for OLFM4, LY6D and S100A7 in 168 ER‐positive breast carcinomas. OLFM4, LY6D and S100A7 immunoreactivities were significantly associated with stage, pathological T factor, distant metastasis and Ki67 status in the ER‐positive breast carcinomas. Moreover, these immunoreactivities were significantly associated with a worse prognostic factor for distant metastasis‐free and breast cancer‐specific survival in ER‐positive stage I‐III breast cancer patients. However, when we performed immunohistochemistry for OLFM4, LY6D and S100A7 in 40 ER‐negative breast carcinomas, these immunoreactivities were not generally associated with the clinicopathological factors examined, including distant metastasis and prognosis of patients, in this study. These results suggest that OLFM4, LY6D and S100A7 immunoreactivity are associated with an aggressive phenotype of ER‐positive breast carcinoma, and these are potent markers for distant metastasis of ER‐positive breast cancer patients.     

浅述卵巢早衰证型分布特点

卵巢早衰一般归属于中医“闭经”、“血枯”、“不孕”、“月经过少”等范畴,近年来,其发病率有上升趋势,然就本病的中医证型分布特点,尚无统一定论。本文通过对卵巢早衰证型分布相关文献的分析、概括,阐述卵巢早衰证型的分布特点,旨在探究更加权威、标准、规范、统一的中医证型,从而准确无误地辨证论治、提高临床疗效。     

HIV感染者皮肤表征及研究进展

皮肤损害往往是HIV感染者最早和最常见症状,通过对文献的分析总结HIV感染者皮肤疾病的发生特点和研究进展。发现近年来的研究偏重于HIV感染者皮肤疾病方面的流行病学,而且都得出较高的发病率。但在皮肤疾病与免疫系统之间的关系研究还不透彻。     

住院网络成瘾青少年的父母养育方式与人格特征

目的探讨住院网络成瘾(Internet Addiction Disorder,IAD)青少年的父母养育方式及人格特征。方法采用网络成瘾临床诊断标准、艾森克人格问卷(EPQ),父母养育方式评定量表(EMBU),对596名被诊断为IAD的青少年施测,比较住院IAD者与对照组的差异。结果IAD青少年父亲情感温暖(FF1)分值低于对照组,过分干涉(FF3)、拒绝否认(FF5)分值高于对照组。IAD青少年的母亲情感温暖(MF1)分值亦低于对照组,而过分干涉保护(MF2)、拒绝否认(MF3)及惩罚严厉(MF4)因子均高于对照组(P<0.01)。IAD青少年的内外向(E)因子分明显低于对照组(P<0.01)、精神质(P)因子分高于对照组(P<0.05)。结论住院IAD青少年存在不良的家庭教养方式,同时存在人格问题。     

抑郁症患者临床特征的性别差异

目的探讨性别因素对抑郁症的影响。方法符合CCMD-3抑郁症诊断标准共195例,按男、女性别分组进行一般情况、汉密尔顿抑郁量表(HAMD)、明尼苏达多项人格测定(MMPI)评定。结果男性抑郁症未婚多、离婚少,首次发病和本次住院年龄小;HAMD评分睡眠障碍轻;MMPI测试D、Mf、Pt和Sc分高。结论男女抑郁症患者临床症状的差异较少,男性抑郁症病理性异常更严重,可能是社会文化变迁对男女心理尤其是人格的影响,并在抑郁症的病理塑形中反映出来。     

深圳市高血压患者血压控制情况与周围绿地特征的关联分析

目的:探讨高血压患者血压控制情况与周围绿地特征的关系。方法:深圳市基本公共卫生服务管理满一年的≥35岁高血压患者为研究对象。采用分层多阶段随机抽样方法抽取代表性样本1 158人,回收有效问卷1 116份,应答率为96.4%。于2019年11月至2020年1月对纳入分析的1 116人进行问卷调查、体格测量、实验室检测。采...