全文获取类型
收费全文 | 52885篇 |
免费 | 1651篇 |
国内免费 | 842篇 |
专业分类
耳鼻咽喉 | 865篇 |
儿科学 | 1213篇 |
妇产科学 | 583篇 |
基础医学 | 2293篇 |
口腔科学 | 1090篇 |
临床医学 | 4540篇 |
内科学 | 3892篇 |
皮肤病学 | 145篇 |
神经病学 | 7873篇 |
特种医学 | 2230篇 |
外科学 | 14094篇 |
综合类 | 7484篇 |
一般理论 | 1篇 |
预防医学 | 1646篇 |
眼科学 | 579篇 |
药学 | 3122篇 |
30篇 | |
中国医学 | 1872篇 |
肿瘤学 | 1826篇 |
出版年
2023年 | 424篇 |
2022年 | 1057篇 |
2021年 | 1543篇 |
2020年 | 1161篇 |
2019年 | 2775篇 |
2018年 | 2576篇 |
2017年 | 1858篇 |
2016年 | 1247篇 |
2015年 | 1297篇 |
2014年 | 2807篇 |
2013年 | 2765篇 |
2012年 | 2698篇 |
2011年 | 2777篇 |
2010年 | 2390篇 |
2009年 | 2254篇 |
2008年 | 2263篇 |
2007年 | 2238篇 |
2006年 | 1911篇 |
2005年 | 1660篇 |
2004年 | 1493篇 |
2003年 | 1362篇 |
2002年 | 1273篇 |
2001年 | 1194篇 |
2000年 | 1033篇 |
1999年 | 957篇 |
1998年 | 742篇 |
1997年 | 656篇 |
1996年 | 507篇 |
1995年 | 467篇 |
1994年 | 382篇 |
1993年 | 306篇 |
1992年 | 304篇 |
1991年 | 256篇 |
1990年 | 238篇 |
1989年 | 213篇 |
1988年 | 198篇 |
1987年 | 195篇 |
1985年 | 684篇 |
1984年 | 606篇 |
1983年 | 444篇 |
1982年 | 539篇 |
1981年 | 469篇 |
1980年 | 504篇 |
1979年 | 410篇 |
1978年 | 392篇 |
1977年 | 256篇 |
1976年 | 416篇 |
1975年 | 336篇 |
1974年 | 299篇 |
1973年 | 283篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
IntroductionHip displacement is common in cerebral palsy (CP) and is related to the severity of neurological and functional impairment. It is a silent, but progressive disease, and can result in significant morbidity and decreased quality of life, if left untreated. The pathophysiology of hip displacement in CP is a combination of hip flexor-adductor muscle spasticity, abductor muscle weakness, and delayed weight-bearing, resulting in proximal femoral deformities and progressive acetabular dysplasia. Due to a lack of symptoms in the early stages of hip displacement, the diagnosis is easily missed. Awareness of this condition and regular surveillance by clinical examination and serial radiographs of the hips are the key to early diagnosis and treatment.Hip surveillance programmesSeveral population-based studies from around the world have demonstrated that universal hip surveillance in children with CP allows early detection of hip displacement and appropriate early intervention, with a resultant decrease in painful dislocations. Global hip surveillance models are based upon the patients’ age, functional level determined by the Gross Motor Function Classification system (GMFCS), gait classification, standardized clinical exam, and radiographic indices such as the migration percentage (MP), as critical indicators of progressive hip displacement.ConclusionDespite 25 years of evidence showing the efficacy of established hip surveillance programmes, there is poor awareness among healthcare professionals in India about the importance of regular hip surveillance in children with CP. There is a need for professional organizations to develop evidence-based guidelines for hip surveillance which are relevant to the Indian context. 相似文献
6.
Qing-Yang Que Lin-Cheng Zhang Jia-Qi Bao Sun-Bin Ling Xiao Xu 《World journal of gastrointestinal surgery》2022,14(5):397-408
Over the last 40 years, the incidence and prevalence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have continued to increase. Compared to other epithelial neoplasms in the same organ, GEP-NENs exhibit indolent biological behavior, resulting in more chances to undergo surgery. However, the role of surgery in high-grade or advanced GEP-NENs is still controversial. Surgery is associated with survival improvement of well-differentiated high-grade GEP-NENs, whereas poorly differentiated GEP-NENs that may benefit from resection require careful selection based on Ki67 and other tissue bio markers. Additionally, surgery also plays an important role in locally advanced and metastatic disease. For locally advanced GEP-NENs, isolated major vascular involvement is no longer an absolute contraindication. In the setting of metastatic GEP-NENs, radical intended surgery is recommended for patients with low-grade and resectable metastases. For unresectable metastatic disease, a variety of surgical approaches, including cytoreduction of liver metastasis, liver transplantation, and surgery after neoadjuvant treatment, show survival benefits. Primary tumor resection in GEP-NENs with unresectable metastatic disease is associated with symptom control, prolonged survival, and improved sensitivity toward systemic therapies. Although there is no established neoadjuvant or adjuvant strategy, increasing attention has been given to this emerging research area. Some studies have reported that neoadjuvant therapy effectively reduces tumor burden, improves the effectiveness of subsequent surgery, and decreases surgical complications. 相似文献
7.
Omar Abdel-Rahman 《Clinical genitourinary cancer》2019,17(2):e329-e338
Background
The objective of the study was to evaluate the outcomes of clinically localized prostate cancer treated with prostatectomy versus radiation therapy within the context of a prospective prostate cancer screening study.Patients and Methods
Within the PLCO (Prostate, Lung, Colorectal, and Ovary) trial, patients who were diagnosed with clinically localized prostate cancer and subsequently received treatment with prostatectomy or radiation therapy (with or without hormonal treatment) were included. Univariate and multivariate Cox regression analyses were then performed to determine factors affecting overall and prostate cancer-specific survival. Factors with P < .05 in univariate analysis were included in the multivariate analysis.Results
A total of 3953 patients were included in the current analysis. These included 2044 patients treated with prostatectomy and 1909 patients treated with radiation therapy with or without hormonal treatment. In an adjusted multivariate analysis for factors affecting overall survival, prostatectomy was associated with better overall survival compared with radiation therapy (hazard ratio, 0.548; 95% confidence interval [CI], 0.440- 681; P < .001). Likewise, in an adjusted multivariate analysis for factors affecting prostate cancer-specific survival, prostatectomy was associated with better prostate cancer-specific survival compared with radiation therapy (hazard ratio, 0.485; 95% CI, 0.286- 0.822; P = .007). Similar findings were found with propensity score matching and repeating the same analyses on the post-matching cohort.Conclusion
Prostatectomy seems to predict better overall and prostate cancer-specific survival compared with radiation therapy among patients with clinically localized prostate cancer diagnosed within the PLCO trial. 相似文献8.
《中国现代医生》2020,58(4):50-53
目的探讨单孔胸腔镜手术治疗结核性脓胸的应用价值,并总结相关临床经验。方法回顾性分析我院胸外科2015年1月~2017年12月住院手术治疗的120例结核性脓胸患者。依据纳入、排除的相关标准,在知情同意下将纳入患者随机分为研究组(单孔胸腔镜手术组,60例)和对照组(传统开胸手术组,60例),比较两组患者的手术时间、术中出血量、术后引流量、胸腔引流管时间、术后住院时间及术后并发症。结果两组患者围术期均无死亡病例,中转开胸3例,中转开胸率为5%(3/60)。单孔胸腔镜组与传统开胸组相比较,手术时间分别为(88.00±15.77)min、(87.52±15.66)min,术中出血量分别为(236.33±15.16)mL、(443.75±43.69)mL,术后引流量分别为(423.93±41.49)m L、(663.92±16.28)mL,胸腔引流管时间分别为(2.92±0.10)d、(4.35±1.44)d,术后住院时间分别为(11.50±2.51)d、(13.65±2.52)d,两组患者的术中出血量、术后引流量、胸腔引流管时间及术后住院时间相比,差异均有统计学意义(P均0.05)。比较两组的手术时间,差异无统计学意义(P0.05)。单孔胸腔镜组术后并发症的总的发生率为6.67%(4/60),传统开胸组术后并发症的总发生率为13.33%(8/60)。结论单孔胸腔镜手术治疗结核性脓胸创伤小、并发症少、住院时间短,患者恢复快,在临床应用中值得推广。但在临床实际中应根据患者病情合理选择手术方式。 相似文献
9.
Lara Silveira Abdo Aguiar Rita de Cssia Rossini Lismary Aparecida de Forville Mesquita Gerson Dellatorre 《Journal of Cosmetic Dermatology》2019,18(6):1733-1736
Depigmented lesions may occur as postinflammatory sequelae of subacute cutaneous lupus erythematosus (SCLE), leading to great psychosocial impact. A 53‐year‐old male patient presented with post‐SCLE depigmented facial lesions after five years of disease stability. We proposed surgical treatment with melanocyte‐keratinocyte transplantation procedure (MKTP), and after five months the patient achieved 90% repigmentation, without Koebner phenomenon (KP). In theory, KP is a possible complication of MKTP procedure since the preparation of the receptor area involves the use of dermabrasion. In an attempt to avoid it, we suggest to maintain the treatment of the underlying disease and wait for a minimum period of disease stability before the procedure. 相似文献
10.
Nicholas E. Anton Tomoko Mizota Lava R. Timsina Jake A. Whiteside Erinn M. Myers Dimitrios Stefanidis 《American journal of surgery》2019,217(2):266-271