全文获取类型
收费全文 | 154篇 |
免费 | 0篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 2篇 |
妇产科学 | 1篇 |
基础医学 | 14篇 |
口腔科学 | 12篇 |
临床医学 | 9篇 |
内科学 | 47篇 |
皮肤病学 | 1篇 |
神经病学 | 9篇 |
特种医学 | 3篇 |
外科学 | 34篇 |
预防医学 | 3篇 |
眼科学 | 5篇 |
药学 | 1篇 |
肿瘤学 | 5篇 |
出版年
2021年 | 5篇 |
2019年 | 40篇 |
2018年 | 27篇 |
2017年 | 16篇 |
2003年 | 1篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1985年 | 4篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1979年 | 4篇 |
1978年 | 8篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1973年 | 3篇 |
排序方式: 共有154条查询结果,搜索用时 453 毫秒
1.
Masaharu Muranaka Shuji Suzuki Kazuhiro Koizumi Hiroshi Igarashi Hiroshi Okumura Koyo Takeda Kenji Tadokoro Yoshihiko Horiuchi 《The Journal of allergy and clinical immunology》1978,62(5):276-282
All of the five commercially available benzylpenicillin preparations obtained from different sources and a PcG preparation prepared by filtration of a commercial PcG on Sephadex G10 elicited the systemic anaphylactic reactions in guinea pigs which had been immunized with benzylpenicilloyl (BPO)-Ascaris extract conjugate (BPO-As) mixed with aluminum hydroxide gel. These preparations could evoke no such reactions in guinea pigs immunized with BPO-bovine gamma globulin conjugate (BPO-BGG) emulsified with complete Freund's adjuvant. The severity of the systemic anaphylactic reactions correlated significantly with the titers of either 8-day passive cutaneous anaphylactic (8-day PCA) reactions or 4-hr PCA reactions evoked with the same benzylpenicillin preparations. In vitro benzylpenicillin preparation contracted the tracheas of the guinea pigs immunized with BPO-As. These results indicated that the commercially available benzylpenicillin preparations have enough antigenicity to evoke systemic anaphylactic reactions in guinea pigs immunized with BPO-As mixed with aluminum hydroxide gel. Such guinea pigs represent an animal model for investigation of penicillin allergy. 相似文献
2.
Mami Kizawa Yu Nakagama Takahiro Shindo Seishi Ogawa Ryo Inuzuka 《The Canadian journal of cardiology》2018,34(10):1369.e5-1369.e7
Because of the rare co-occurrence, it remains a question whether cardiomyopathy is a true association of neurofibromatosis type 1. A boy with café-au-lait spots manifested restrictive cardiomyopathy. Whole exome sequencing confirmed the genetic diagnosis of neurofibromatosis and further identified a novel titin (TTN) missense variant. The significance of the variant is supported by its de novo origin, in silico predictions, and evolutionary conservation. Modern genetics raises an intriguing explanation for the unexpected phenotype and adds to the evolving role of TTN variants in cardiomyopathy. 相似文献
3.
Thuy Lam Vo Manabu Kanazawa Khaing Myat Thu Mari Asami Daisuke Sato Shunsuke Minakuchi 《Journal of prosthodontic research》2019,63(4):428-433
PurposeThe study aimed to compare the mixing ability (MA), comminuting ability (CA), and maximum bite force (MBF) of single-implant overdentures (IODs) and clinically acceptable complete dentures (CDs) through a randomized crossover control trial.MethodsNew CDs were fabricated for 22 patients. One implant was inserted in the middle of the symphyseal region for each patient. The patients were randomly allocated into two groups: group IC received an IOD, whereas group CI received a CD, for 2 months; the treatments were interchanged for the next 2 months. The MA, CA, and MBF were evaluated with the old CDs, new CDs (at the end of CD treatment period), and IODs (at the end of IOD treatment period).ResultsThe MA, CA, and MBF of the IODs were significantly higher than those of the old and new CDs (p < 0.01). New CDs only showed a significant improvement in MA (p < 0.05), while there were no significant differences in CA and MBF between the old and new CDs.ConclusionsCompared with the CD, IOD is more effective in restoring the MA, CA, and MBF of edentulous mandibles. 相似文献
4.
Keisuke Usui Akira Isobe Naoya Hara Naoto Shikama Keisuke Sasai Koichi Ogawa 《Medical Dosimetry》2019,44(4):344-353
Total body irradiation (TBI) using helical tomotherapy (HT) has advantages over the standard linear accelerator-based approach to the conditioning regimen for hematopoietic cell transplantation. However, the radiation field has to be divided into two independent irradiation plans to deliver a homogeneous dose to the whole body. A clinical target volume near the skin increases the skin surface dose; therefore, high- or low-dose regions arise depending on the set-up position accuracy because the two radiation fields are somewhat overlapped or separated. We aimed to determine an adequate treatment planning method robust to the set-up accuracy for the field joint dose distribution using HT-TBI. We calculated treatment plans reducing target volumes at the interface between the upper and lower body irradiations and evaluated these joint dose distributions via simulation and experimental studies. Target volumes used for the optimization calculation were reduced by 0, 0.5, 1.0, 2.0, 2.5, and 3.0 cm from the boundary surface on the upper and lower sides. Combined dose distributions with set-up error simulated by modifying coordinate positions were investigated to find the optimal planning method. In the ideal set-up position, the target volume without a gap area caused field junctional doses of up to approximately 200%; therefore, target volumes reduced by 2.0–3.0 cm could suppress the maximum dose to within 150%. However, with set-up error, high-dose areas exceeding 150% and low-dose areas below 100% were found with 2.0 and 3.0 cm target volume reduction. Using the dynamic jaw (DJ) system, dose deviations caused by set-up error reached approximately 20%, which is not suitable for HT-TBI. Moreover, these dose distributions can be easily adjusted when combined with the intensity modulation technique for field boundary regions. The results of a simulation and experimental study using a film dosimetry were almost identical, which indicated that reducing the target volume at the field boundary surface by 2.5 cm produces the most appropriate target definition. 相似文献
5.
Hirotaka Miyashita Koh Okamoto Tatsuya Kobayashi Yoshitaka Wakabayashi Satoshi Kitaura Kazuhiko Ikeuchi Kazunaga Ishigaki Yosuke Nakai Shu Okugawa Kazuhiko Koike Kyoji Moriya 《Journal of infection and chemotherapy》2019,25(6):473-476
Bacterial peritonitis, an infection of the ascitic fluid, can be classified etiologically as spontaneous or secondary bacterial peritonitis. The former is mainly caused by portal hypertension and its subsequent effects, whereas the latter is caused by the direct dissemination of bacteria into the peritoneal cavity. Previous reports have described some distinguishing features of these two entities. Here, we report the first known case of bacterial peritonitis with Aeromonas hydrophilia and Escherichia coli in a patient with malignant ascites associated with pancreatic carcinoma who exhibited features of both spontaneous and secondary peritonitis. Our report suggests that clinicians should also consider bacterial peritonitis in patients with malignant ascites who present with ostensibly cancer-related symptoms. 相似文献
6.
S. Yoshihara S. Baba A. Kanemaru T. Ichikawa 《European annals of otorhinolaryngology, head and neck diseases》2019,136(5):393-395
IntroductionPenetrating craniofacial injuries caused by stick-like foreign bodies occur as a result of accidents particularly in children, and often lead to significant morbidity.Case summaryWe describe a 5-year-old boy who sustained facial trauma after falling on a wooden stick which penetrated his left cheek. At the initial visit, his vital and neurological signs were normal. However, the stick had penetrated the frontal lobe to a depth of 3 cm via the orbital cavity and the anterior skull base. The stick was successfully removed while visualizing the anterior skull base in an endoscopic transethmoidal approach. A follow-up examination one year after the accident demonstrated normal visual acuity and ocular motility, with no diplopia, tearing or pain.DiscussionPenetrating facial injuries caused by stick-like objects carry a significantly higher risk of serious neurological involvement. Even if penetrating facial injuries sometimes appear trivial, the external injury site is often insufficient to determine the position of the object within the head. Although the cheek is a rare entry site for intracranial injuries, the extent of damage should be assessed fully before attempting removal. 相似文献
7.
Hisako Katano Hideyuki Koga Nobutake Ozeki Koji Otabe Mitsuru Mizuno Makoto Tomita Takeshi Muneta Ichiro Sekiya 《Journal of orthopaedic science》2018,23(4):676-681
Background
Meniscus surgery is the most commonly performed orthopedic surgery, and despite recent emphasis on saving the meniscus, the current status of meniscus surgeries is little known in many countries, including Japan. The National Database of Health Insurance Claims and Specific Health Checkups of Japan and the Statistics of Medical Care Activities in Public Health Insurance track meniscus surgeries through health insurance claims. The National Database provides the numbers for 2014 and 2015, and the Statistics of Medical Care Activities provides the numbers from June 2011 to June 2016. Our aim was to analyze isolated meniscus surgery numbers and meniscus repair ratios by age group based on the National Database and evaluate trends of meniscus repair ratios for the latest six years from the Statistics of Medical Care Activities.Methods
Meniscus surgeries by age group were counted from the National Database for 2014–2015, and meniscus repair ratios (meniscus repairs/meniscus surgeries) were calculated. The numbers were also counted from the Statistics of Medical Care Activities in 2011–2016. For statistical analysis of annual trends of meniscus repair ratios, the Cochran–Armitage trend test was used. Meniscus surgeries with concomitant knee ligament surgeries were excluded.Results
According to the National Database, isolated meniscus surgeries totaled 34,966 in 2015, with peak ages of patients in their late teens and 60s. The meniscus repair ratio was 19% in 2014 and 24% in 2015. According to the Statistics of Medical Care Activities, the meniscus repair ratio was 9% in 2011 and significantly increased to 25% in 2016 (p = 0.0008). The ratio also increased significantly in each age group between the early 20s and late 70s.Conclusions
Approximately 35,000 meniscus surgeries are performed in Japan annually, with peak ages in the late teens and 60s. The number of meniscus repairs has increased over the past six years. 相似文献8.
9.
Regular and irregular astigmatism after superior versus temporal scleral incision cataract surgery 总被引:6,自引:0,他引:6
OBJECTIVE: To evaluate the effect of superior and temporal scleral incisions on regular and irregular astigmatism in small incision cataract surgery. DESIGN: Prospective, randomized, comparative clinical trial. PARTICIPANTS: One hundred seventy-four eyes of 87 patients with bilateral cataracts scheduled to undergo routine cataract surgery. METHODS: One eye of each patient was randomly assigned to the superior incision group, and the contralateral eye was allocated to the temporal incision group. Phacoemulsification and intraocular lens implantation were performed through an unsutured 4.1-mm scleral incision. Patients were examined 1 day and 1, 3, and 6 months after surgery. MAIN OUTCOME MEASURES: Surgically-induced regular astigmatism calculated with vector analysis method, irregular astigmatism obtained by Fourier analysis of videokeratography data, and uncorrected and corrected visual acuity. RESULTS: Postoperatively, the superior incision group showed slight against-the-rule astigmatic changes, whereas slight with-the-rule astigmatism was seen in the temporal incision group. The amount of against-the-wound astigmatism and absolute value of length of the induced vector did not differ significantly between groups (P > 0.05, paired t test). In both groups, irregular astigmatism 1 day after surgery was significantly greater than the preoperative levels (P < 0.001), but not thereafter. No significant intergroup difference was observed in the amount of irregular astigmatism at any postoperative visits (P > 0.05). There was no significant difference in uncorrected and corrected visual acuity between groups postoperatively (P > 0.05, chi-square test). CONCLUSIONS: In small scleral incision cataract surgery, superior and temporal approaches are comparable in terms of visual rehabilitation and induction of regular and irregular astigmatism. 相似文献
10.
Hideo Torii Keizo Takahashi Fumiaki Yoshitomi Kazunori Miyata Yasuo Ishii Tetsuro Oshika 《Ophthalmology》2001,108(12):2182-2185