全文获取类型
收费全文 | 1726篇 |
免费 | 102篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 20篇 |
妇产科学 | 23篇 |
基础医学 | 117篇 |
口腔科学 | 12篇 |
临床医学 | 190篇 |
内科学 | 264篇 |
皮肤病学 | 336篇 |
神经病学 | 186篇 |
特种医学 | 18篇 |
外科学 | 192篇 |
综合类 | 172篇 |
预防医学 | 29篇 |
眼科学 | 95篇 |
药学 | 102篇 |
中国医学 | 67篇 |
肿瘤学 | 33篇 |
出版年
2024年 | 5篇 |
2023年 | 25篇 |
2022年 | 50篇 |
2021年 | 75篇 |
2020年 | 95篇 |
2019年 | 54篇 |
2018年 | 73篇 |
2017年 | 57篇 |
2016年 | 47篇 |
2015年 | 76篇 |
2014年 | 116篇 |
2013年 | 167篇 |
2012年 | 92篇 |
2011年 | 92篇 |
2010年 | 71篇 |
2009年 | 84篇 |
2008年 | 81篇 |
2007年 | 57篇 |
2006年 | 46篇 |
2005年 | 69篇 |
2004年 | 57篇 |
2003年 | 47篇 |
2002年 | 37篇 |
2001年 | 35篇 |
2000年 | 20篇 |
1999年 | 19篇 |
1998年 | 33篇 |
1997年 | 24篇 |
1996年 | 19篇 |
1995年 | 16篇 |
1994年 | 15篇 |
1993年 | 9篇 |
1992年 | 10篇 |
1991年 | 15篇 |
1990年 | 8篇 |
1989年 | 9篇 |
1988年 | 9篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 9篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1972年 | 1篇 |
排序方式: 共有1872条查询结果,搜索用时 15 毫秒
1.
2.
3.
Central Sensitization Theory of Migraine: Clinical Implications 总被引:4,自引:2,他引:2
The clinical science of migraine headache continues to evolve. Theories of the pathophysiology of migraine have progressed from the early vascular basis of migraine to more complex current theories that emphasize the centrality of neuronal dysfunction. The most recently articulated theory of migraine is the central sensitization hypothesis, which proposes that altered processing of sensory input in the brainstem, principally the trigeminal nucleus caudalis, could account for many of the temporal and symptomatic features of migraine, as well as its poor response to triptan therapy when such treatment is initiated hours after the onset of pain. Both preclinical and clinical data support the central sensitization theory. A critical clinical implication of this theory is that drugs that are capable of either aborting or arresting the process of central sensitization, most prominently dihydroergotamine, may have a unique role in the treatment of migraine. An additional, and highly practical, implication is based upon the finding that cutaneous allodynia—pain arising from innocuous stimulation of the skin, as in hair brushing or the application of cosmetics—is an easily identifiable marker of central sensitization. Thus, the presence or absence of cutaneous allodynia can be integrated into the routine clinical assessment of migraine and utilized as a determinant of treatment. Future basic and clinical research on central sensitization is likely to be of ongoing importance to the field. 相似文献
4.
Although fever may induce seizures, especially in children, its occurrence following epileptic spells has been rarely described, except from generalized convulsive status epilepticus. We present two patients suffering from focal seizures accompanied by episodes of post-ictal fever, and review similar reports in the literature of the last 40 years. Temperature changes following non-convulsive seizures might be induced by gene upregulation occurring in the hypothalamus, the nucleus tractus solitarius, or in other brain regions, producing a local inflammatory response. Direct propagation of electrical discharges seems less consistent with the timing of development of this symptom. Heterogeneity of reported clinical features argues against the assumption of a definite localizing or lateralizing value for post-ictal fever. 相似文献
5.
Leonardo Bonilha MD PhD Paulien M. de Vries Diana J. Vincent MD PhD Chris Rorden MD PhD Paul S. Morgan Mark W. Hurd PhD Nada Besenski MD Kenneth J. Bergmann MD Vanessa K. Hinson MD PhD 《Movement disorders》2007,22(8):1110-1116
We investigated whether structural white matter abnormalities, in the form of disruption of axonal coherence and integrity as measured with diffusion tensor imaging (DTI), constitute an underlying pathological mechanism of idiopathic dystonia (ID), independent of genotype status. We studied seven subjects with ID: all had cervical dystonia as their main symptom (one patient also had spasmodic dysphonia and two patients had concurrent generalized dystonia, both DYT1‐negative). We compared DTI MR images of patients with 10 controls, evaluating differences in mean diffusivity (MD) and fractional anisotropy (FA). ID was associated with increased FA values in the thalamus and adjacent white matter, and in the white matter underlying the middle frontal gyrus. ID was also associated with increase in MD in adjacent white matter to the pallidum and putamen bilaterally, left caudate, and in subcortical hemispheric regions, including the postcentral gyrus. Abnormal FA and MD in patients with ID indicate that abnormal axonal coherence and integrity contribute to the pathophysiology of dystonia. These findings suggest that ID is not only a functional disorder, but also associated with structural brain changes. Impaired connectivity and disrupted flow of information may contribute to the impairment of motor planning and regulation in dystonia. © 2006 Movement Disorder Society 相似文献
6.
Martina Ballmaier Elizabeth R Sowell Paul M Thompson Anand Kumar Katherine L Narr Helen Lavretsky Suzanne E Welcome Heather DeLuca Arthur W Toga 《Neuropsychopharmacology》2004,55(4):382-389
BACKGROUND: In elderly depression, volumetric brain imaging findings suggest abnormalities of the frontal lobe, particularly the orbitofrontal cortex, and the hippocampus. No studies to date have mapped cortical abnormalities over the entire brain surface in major depression. Here, we conducted detailed spatial analyses of brain size and gray matter within the cortical mantle in elderly patients with major depression. METHODS: High-resolution, three-dimensional, structural magnetic resonance imaging data and cortical pattern matching methods were used in 24 depressed elderly patients and 19 group-matched controls to measure local brain size and proportions of gray matter at thousands of homologous cortical surface locations. RESULTS: Prominent brain size reductions were observed in the depressed subjects in the orbitofrontal cortex bilaterally. Cortical gray matter measurements revealed significant gray matter increases in the orbitofrontal cortex, adjacent to focal trend level significant decreases of gray matter in the same region. Depressed patients also exhibited significant gray matter increases in parietal cortices, as well as the left temporal cortex. CONCLUSIONS: Complex cortical changes may contribute to the brain size reduction of the orbitofrontal cortex and to the gray matter abnormalities detected in orbitofrontal cortex and temporoparietal cortices, thereby providing a potentially new window into the pathophysiology of elderly depression. 相似文献
7.
Vishwa Prakash Raman Tandon Raghav Mantri 《Journal of plastic, reconstructive & aesthetic surgery》2006,59(10):1102-1104
Supragaleal placement of tissue expander for management of alopecia of scalp excludes tough galeal layer so that easier and faster expansion of scalp may be achieved. 相似文献
8.
谢林 《湖南中医药大学学报》1994,14(2):1-3
本文从髌骨软骨软化症的病因病理出发,阐述了活血化瘀疗法治疗髌骨软骨软化症的作用及其原理,列举了活血化瘀法在该病治疗中的具体运用,同时强调了在辨证施治基础上活血化瘀的重要性。 相似文献
9.
Empty Sella and Headache 总被引:2,自引:0,他引:2
Teresa Catarci Fabrizio Fiacco Luigi Bozzao Manuela Pati Alice Valeria Magiar Rosanna Cerbo 《Headache》1994,34(10):583-586
SYNOPSIS
Empty sella is an anatomical condition caused by herniation of the subarachnoid space into the pituitary fossa through an incompetent seller diaphragm. Headache seems to be one of the most frequently reported symptoms. We studied 13 headache patients (12 females, 1 male) presenting with primary empty sella (PES) on CT scan. The characteristics of the headache were analyzed and plasma levels of pituitary hormones or cortisol assessed. We confirmed the nonspecific nature of the headache in PES even though the majority of our patients complained of daily headache, mostly localized anteriorly. Hormone plasma levels were within normal range in all the patients assessed. However, four patients reported earlier endocrine disorders and more than half of the patients presented with obesity.
In our opinion, PES should be suspected in middle-aged overweight women with daily headache even in the absence of endocrine symptomatology. 相似文献
Empty sella is an anatomical condition caused by herniation of the subarachnoid space into the pituitary fossa through an incompetent seller diaphragm. Headache seems to be one of the most frequently reported symptoms. We studied 13 headache patients (12 females, 1 male) presenting with primary empty sella (PES) on CT scan. The characteristics of the headache were analyzed and plasma levels of pituitary hormones or cortisol assessed. We confirmed the nonspecific nature of the headache in PES even though the majority of our patients complained of daily headache, mostly localized anteriorly. Hormone plasma levels were within normal range in all the patients assessed. However, four patients reported earlier endocrine disorders and more than half of the patients presented with obesity.
In our opinion, PES should be suspected in middle-aged overweight women with daily headache even in the absence of endocrine symptomatology. 相似文献
10.
浅议病理生理学教学改革 总被引:3,自引:1,他引:2
本文从病理生理学理论和实验教学两个方面论述了病理生理学方法的改革与实践。教学模式变学生被动为自主学习,在传授知识同时注重培养学生自学创新能力。 相似文献