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1.
Ming-kaiLI Xiao-xingLUO Liang-weiCHEN ZhongCHEN JiaMENG JingHU Yu-meiWU Jing-ruMENG ZhengHOU XueMA 《中国药理通讯》2005,22(2):18-18
AIM To provide the evidence about localization, biosynthesis, metabolism and release of histamine from the cardiac sympathetic nerve terminals, and endogenous sympathetic histamine could inhibit itsel frelease from the nerve terminal through the presynaptic histamine H3 receptor. METHODS Using double-labeled immunohistochemistry to observe the co-localization of histamine and NE in the superior cer-vical ganglia (SCG) of macaca mulatto monkey; Different-speed centrifugation to obtain the cardiac sympathetic nerve terminal model (the cardiac synaptosomes), spectrofluorometer and ELISA techniques to detect the release of histamine from the cardiacsynaptosomes. RESULTS ( 1 ) The coexistence of histamine and norepinephrine immunoreactivities was identified in the same neuron within SCG of macaca mulatto monkey. (2) Depolarization of macaca mulatto monkey cardiac synaptosomes with 50 mmol/L potassium caused the release of endogenous histamine, 相似文献
2.
赞美,即鼓励、强化,是行为科学中的一个概念。它可以给平凡的生活带来希望,可以把世间的噪音化为音乐。赞美对人类心灵的重要性,好比植物依赖于阳光,没有 相似文献
3.
龚晖 《国外医学(药学分册)》1995,22(2):79-82
MCI-154为CI-914和CI-930等哒嗪酮磷酸二酯酶抑制剂的新衍生物,具有较强的强心和扩血管作用,其优点是无显著的正性频率作用,并可改善心脏缺血区的收缩功能,提高心肌收缩蛋白系统对Ca^2+敏感性为其主要强心作用机制,已被列入新型强心药物-钙增敏剂的主要成员,本文介绍其化学结构,药理作用及其作用机制的最新研究结果。 相似文献
4.
Objective: To investigate the anti-inflammatory effect of erythropoietin (EPO) pretreatment on cardiomyocytes exposed to hypoxialreoxygenation injury (H/R) and explore the possible mechanism.
Methods: The cultured neonatal rats' ventricular cardiomyocytes were divided randomly into 4 groups, control group (C group), EPO pretreatment group (E group), EPO and pyrrolidine dithiocarbamate (PDTC) pretreatment group (EP group) and PDTC pretreatment group (P group). After 24 hours' pretreatment, the cardiomyocytes were exposed to H/R. After pretreatment and H/R, the expression of tumor necrosis factor- α (TNF- α ) gene in all the groups was detected by RT-PCR and Western blot. The nuclear factor- κ B (NF- κB) activity was detected by electrophoretic mobility shift assay (EMSA) and the inhibitor- κB α (Ⅰ- κB α) protein level was detected by Western blot.
Results: The decrement of Ⅰ- κB a protein and the increasing NF- KB activity were found in cardiomyocytes pretreated with EPO before H/R compared to other groups (t=3.321, 4.183, P〈0.01). However, after H/R, NF- κB activity and expression of TNF- α gene were significantly reduced, Ⅰ- κB a protein expression was increased in cardiomyocytes of E group compared to other groups (t=-3.425, 3.687, 3.454, P〈0.01). All theses changes caused by EPO pretreatment were eliminated by the intervention of PDTC (an antagonist to NF- κB) during pretreatment.
Conclusions: EPO pretreatment can inhibit the activation of NF- κB and upregulation of TNF- α gene in cardiomyocytes exposed to H/R through a negative feedback of NF- κB signaling pathway, and thus produces the anti-inflammatory effect. This might be one of the ways EPO produces the anti-inflammatory effect. 相似文献
Methods: The cultured neonatal rats' ventricular cardiomyocytes were divided randomly into 4 groups, control group (C group), EPO pretreatment group (E group), EPO and pyrrolidine dithiocarbamate (PDTC) pretreatment group (EP group) and PDTC pretreatment group (P group). After 24 hours' pretreatment, the cardiomyocytes were exposed to H/R. After pretreatment and H/R, the expression of tumor necrosis factor- α (TNF- α ) gene in all the groups was detected by RT-PCR and Western blot. The nuclear factor- κ B (NF- κB) activity was detected by electrophoretic mobility shift assay (EMSA) and the inhibitor- κB α (Ⅰ- κB α) protein level was detected by Western blot.
Results: The decrement of Ⅰ- κB a protein and the increasing NF- KB activity were found in cardiomyocytes pretreated with EPO before H/R compared to other groups (t=3.321, 4.183, P〈0.01). However, after H/R, NF- κB activity and expression of TNF- α gene were significantly reduced, Ⅰ- κB a protein expression was increased in cardiomyocytes of E group compared to other groups (t=-3.425, 3.687, 3.454, P〈0.01). All theses changes caused by EPO pretreatment were eliminated by the intervention of PDTC (an antagonist to NF- κB) during pretreatment.
Conclusions: EPO pretreatment can inhibit the activation of NF- κB and upregulation of TNF- α gene in cardiomyocytes exposed to H/R through a negative feedback of NF- κB signaling pathway, and thus produces the anti-inflammatory effect. This might be one of the ways EPO produces the anti-inflammatory effect. 相似文献
5.
我院应用非洋地黄类强心剂合并酚妥拉明治疗慢性肺源性心脏病 (肺心病 ) ,心力衰竭Ⅱ~Ⅲ度患者 30例 (称治疗组 ) ,与同期应用一般常规治疗 38例 (称对照组 )作对比观察 ,结果治疗组收到了满意疗效 ,现报道如下 :1 临床资料1 1 一般资料我院自 1998年 10月以来 ,在收治的慢性肺心病并发心衰患者中抽取 30例 (治疗组 )和 38例 (对照组 )作治疗统计对照。两组病例年龄均在 5 5~ 70岁 ,肺心病病史 6年以上 ,其原发病有慢性支气管炎、支气管扩张、支气管哮喘并发肺气肿 ,全部病例符合内科学肺心病诊断标准[1]1 2 治疗方法对照组 :采用常规… 相似文献
6.
7.
吕道玲 《中国临床医药实用杂志》2005,(4):29-29
失血性休克病人的病情十分危急,须争分夺秒采取果断手术等措施,麻醉选择更是至关重要,特别是在基层医院,设备条件落后,很多不具备插管条件,麻醉选择受限。选择良好的麻醉方法,达到手术医师的麻醉要求,以及时救治患者至关重要。我院于2000年以来,采用小剂量氯胺酮麻醉用于15例重型失血性休克手术病人,获得满意效果,现报道如下: 相似文献
8.
VirginieMELLIN PaulMULDER BenoitDiMEGLIO JeanPaulHENRY ChristianTHUILLEZ 《Acta pharmacologica Sinica》2004,25(11):1533
AIM: Aldosterone receptor antagonists reduce total and cardiovascular mortality in patients with chronic heart failure (CHF) under active angiotensin converting enzyme inhibition treatment,illustrating the deleterious involvement of aldosterone in the progression of CHF. The reduction of aldosterone synthesis through inhibition of aldosterone synthase is an alternative way to prevent the effects of aldosterone. However, whether chronic aldosterone synthase inhibition exerts beneficial effects in CHF 相似文献
9.
10.
JINYin-bin ZHANGhong HUANGYe-cho JIANGDa-zong 《中国生物医学工程学报(英文版)》2004,13(2):59-71
The Luo-Rudy models of mammalian ventricular cell were chosen in studying cardiac electrophysiology. Rush and Larsen‘s algorithm and adaptive time step methods were used to solve the ordinary differential equations (ODE‘s). The operator splitting (or time splitting) and adaptive time step methods were used to solve the partial differential equations (PDE‘s) in cardiac tissue conduction models. The alternating direction implicit (ADI) method was used to integrate the PDE. Using these methods we accomplished the simulation programs of single cardiomyocyte model, one-dimensional cable model (l-D) and two-dimensional (2-D) tissue model. The methods of initiating spiral waves were studied with these software. The data getting from 2-D simulation can be used for further study on isopotential contour lines, spiral wave tip trajectories, and pseudo-ECG. The software for computer simulation have been successfully used in simulation studying of electrophysiology properties of single cardiomyocyte, conduction in one-dimensional cable model (l-D) and two-dimensional (2-D) tissue model. 相似文献