维生素C对复杂性区域疼痛综合征预防效果的Meta分析

目的本研究通过文献检索分析,评估维生素C在预防四肢创伤或围手术期发生复杂性区域疼痛综合征(CRPS)的有效性。方法用于文献检索的数据库有:Ovid EMBASE,Ovid MEDLINE,CINAHL,the Cochrane Database和中国知网数据库(CNKI),从中检索关于围手术期患者每日服用不少于500mg维生素CRPS发病率的文献。结果根据纳入和排除标准对所检索的文献进行筛选,选中5篇文献进行Meta分析,其中1篇是关于足踝创伤或手术患者,另4篇是关于上肢创伤患者。所有5篇文献的研究均满足了除干预措施外的最小异质性(Tau~2=0.00)。最终Meta分析显示,在患肢受伤或手术后口服维生素C至少500mg,疗程50d,比值比(OR)为0.20[95%CI=(0.12,0.34)]。结论创伤或术后当天开始服用维生素C可以有效预防CRPS的发生。     

角膜碱烧伤早期地塞米松与维生素C局部治疗实验研究

目的探讨角膜碱烧伤早期地塞米松局部治疗的病理学基础。方法将双眼角膜碱烧伤30只兔分成5组：地塞米松组、维生素C组、地塞米松＋维生素C组、地塞米松和维生素C间断联合治疗组及烧伤对照组，进行疗效观察。结果间断联合组角膜溃疡发生率明显降低，角膜上皮修复率明显升高，与其余各组相比差异显著（P＜0．05－P＜0.01）。结论角膜碱烧伤早期地塞米松＋维生素C局部治疗是有意义的。     

维生素C Na胶囊与维生素C片剂的相对生物利用度比较

用高效液相色谱法测定人血中Vc,对10名健康志愿者po Vc Na胶囊的相对生物利用度及其药物动力学进行研究.结果受试药Vc Na胶囊和对照药Vc片的C_(max)为(67.71±24.13)和(74.33±17.50)μmol/L;T_(1/2)为(7.44±2.00)和(7.69±3.07)h;AUC为(746.4±411.4)和(785.4±428.8)μmol·h/L.各参数经配对t检验均无显著性差异,显示两种制剂体内吸收、分布和消除基本一致.Vc-Na胶囊人体相对生物利用度为(95.1±9.1)%.提示Vc Na胶囊可作为Vc在临床上应用.     

预先静脉注射维生素C对兔脊髓缺血再灌注损伤的保护作用

目的：探讨预先静脉注射维生素C注射液对免脊髓缺血再灌注损伤的作用,并为其临床应用提供依据。方法：30只成年雄性家兔随机分成假手术组（A组）、缺血对照组（B组）、维生素c组（c组）各10只。A组仅松套腹主动脉;B组阻断左肾动脉下腹主动脉40min后再灌注4d,建立脊髓缺血再灌注损伤模型;C组于阻断腹主动脉前15min一次性静脉注射维生素c注射液0．5g／kg,其余操作同B组。于缺血即刻,再灌注即刻、2h、4h、8h、16h测定血清丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性;于再灌注24h、48h和96h采用Tarlov评分评定后肢神经功能;于再灌注96h观察脊髓组织病理学改变。结果：缺血再灌注各时点,家兔血清MDA含量：A组〈C组〈B组;SOD活性：A组〉c组〉B组;B组和c组间差异有统计学意义（P％0．05）。于各评定时间点,A组家兔无瘫痪,B组10只均完全性瘫痪,C组仅3只完全性瘫痪,B组和C组间差异有统计学意义（P〈0．05）。于再灌注96h与B组比较,C组家兔脊髓前角正常神经细胞数较多,凋亡神经元较少（P〈0．05）。结论：预先静脉注射维生素C对免脊髓缺血再灌注损伤有较好的保护作用。     

Are retinol,vitamin C,vitamin E,folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study

In the Netherlands Cohort Study among 120 852 subjects aged 55-69 years at baseline (1986), the association between vitamins and carotenoids intake, vitamin supplement use, and bladder cancer incidence was examined. Exposure status was measured with a food-frequency questionnaire. After 6.3 years of follow-up, data from 569 cases and 3123 subcohort members were available for case-cohort analyses. The age-, sex-, and smoking-adjusted relative risks (RRs) for retinol, vitamin E, folate, a-carotene, b-carotene, lutein and zeaxanthin, and lycopene were 1.04, 0.98, 1.03, 0.99, 1.16, 1.11, and 1.08, respectively, comparing highest to lowest quintile of intake. Only vitamin C (RR: 0.81, 95% CI: 0.61-1.07, P-trend = 0.08), and b-cryptoxanthin intake (RR: 0.74, 95% CI: 0.53-1.03, P-trend < 0.01) were inversely associated with bladder cancer risk. The association with vitamin C disappeared after adjustment for b-cryptoxanthin but not vice versa. The RRs for supplemental use of vitamin A, C or E compared to no use were around unity. We conclude that dietary or supplemental intake of vitamin A, vitamin C, vitamin E, and intake of folate, and most carotenoids are not associated with bladder cancer. In this study, only b-cryptoxanthin intake appeared to be inversely associated.