外阴硬化性萎缩性苔藓伴先天性皮肤异色症1例

报告1例外阴硬化性萎缩性苔藓伴先天性皮肤异色症。患者女性，17岁，因外阴白斑伴瘙痒8年就诊。皮损主要表现为外、会阴及肛周有呈哑铃状角化白色斑片，胸背及双上肢伸侧有网状色素沉着斑，伴毛细血管扩张和轻度萎缩性白斑，家庭中有皮肤异色症患者。组织病理改变符合硬化性萎缩性苔藓。     

60例硬肿病临床分析

本文分析30例硬肿病的临床和实验室资料,包括临床表现、血液流变学、病理,超微结构等方面的观察结果。提示本病不仅有皮肤损害,还有系统症状,预后并非完全良好,严重者可丧失劳动能力并危及生命,因此,应重视对本病的治疗和随访。     

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目的    观察Nd：YAG激光处理后硬化牙本质表面的超微形态改变。方法    选取2009年6 — 8月中国医科大学附属口腔医院口腔颌面外科拔除的具有典型牙合面磨损牙15颗,随机分为黏结剂组、激光＋黏结剂组及对照组,每组5颗牙。黏结剂组采用Adper Prompt L-Pop处理15 s;激光＋黏结剂组采用Nd：YAG激光进行预处理后,再用Adper Prompt L-Pop处理15 s;对照组不做任何处理,扫描电镜观察表面形态变化。结果    扫描电镜观察发现,对照组硬化牙本质表面呈现无结构的组织,表面有污染层,部分牙本质小管口暴露;黏结剂组硬化牙本质表面污染层被去除,牙本质小管暴露,部分小管内可见突出表面的矿化晶柱;激光＋黏结剂组牙本质表面较干净,呈现凹凸不平状,有硬化柱的牙本质小管数量相对减少。结论    Nd：YAG激光联合Adper Prompt L-Pop处理能够更有效地去除污染层及牙本质小管内的硬化柱,粗化硬化牙本质表面。     

Er,Cr∶YSGG激光备洞对老年人非龋性硬化牙本质微拉伸粘接强度的影响

目的评价Er,Cr∶YSGG激光备洞对硬化牙本质微拉伸粘接强度的影响,并比较其对两种不同充填材料粘接强度的影响。方法 40颗带有楔状缺损的老年人前磨牙,表面有典型硬化牙本质,随机分成实验组和对照组。实验组用Er,Cr∶YSGG激光备洞,对照组用牙科高速涡轮手机备洞,实验组和对照组再各分两个亚组,均分别用复合树脂和玻璃离子水门汀充填。所有样本在37℃蒸馏水中放置24 h,然后制备成厚度约1 mm的哑铃型片状试件,在Instron 5848微力试验机上测定微拉伸粘接强度,在扫描电镜下观察牙本质断面的表面形态。结果实验组中复合树脂组的微拉伸粘接强度为（35.24 7.05）Mpa,玻璃离子水门汀组微粒伸粘接强度（17.71 5.74）Mpa,对照组中复合树脂组微粒伸粘接强度（27.56 4.79）Mpa,玻璃离子水门汀组微粒伸粘接强度（11.47 5.12）Mpa。实验组和对照组的微拉伸粘接强度比较差异有显著意义（P〈0.05）,两组复合树脂组和玻璃离子水门汀组的微拉伸粘接强度比较;差异有显著意义（P〈0.05）。结论 Er,Cr∶YSGG激光备洞老年人非龋性硬化牙本质后的粘接强度高于高速涡轮手机预备者,复合树脂的粘接强度优于玻璃离子水门汀。     

硬皮病小鼠皮损TGF-β_1 I,III型胶原含量及其相关性分析

目的探讨转化生长因子(TGFβ1)在硬皮病发病中的作用及其与COLI,COLIII含量的相关性。方法采用免疫组化技术检测7例硬皮病小鼠模型的皮损中TGFβ1蛋白及I,III型胶原蛋白含量,以7例正常小鼠皮肤组织作为对照(不加BLM的PBS液处置);并对I,III型胶原及TGFβ1的含量进行比较和相关分析。结果TGFβ1及I,III型胶原在硬皮病小鼠皮损的含量均高于对照组(P<0.001);相关分析表明I型胶原的含量与TGFβ1的含量呈正相关(P<0.05)。结论在硬皮病小鼠皮损中有较多的TGFβ1,且硬化皮肤中TGFβ1与I型胶原的含量有显著相关性。提示其在小鼠皮肤硬化过程中起一定作用,可能与硬皮病的病理纤维化的形成有关。     

Tracheoesophageal and anal atresia in prenatal children exposed to a high dose of alcohol

A half-century ago Otto Ullrich became the first clinical geneticist to assume the Chairmanship of a clinical department in a medical school. Clinical genetics owes Ullrich the delineation and definition of several important genetic diseases and syndromes, most importantly the condition named after him and Henry Turner. This paper reports on Ullrich's teacher, his career, his personality, and “his” syndromes.     

Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases

In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study, recruiting patients with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized graft versus host disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p < 0.01) and shear wave speed 128% higher (p < 0.005) compared to those in normal skin—indicating stiffer mechanical properties in the sclerotic skin. This trend persisted through disease types. We conclude ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis.