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《Diagnostic Histopathology》2022,28(12):522-533
Neoplasms of bone with numerous non-neoplastic osteoclast type giant cells are relatively common and exhibit diverse phenotypes of the neoplastic cells. These tumors have a broad spectrum of biological potential which necessitates accurate recognition and diagnosis. Their clinicopathological features are overlapping, therefore, immunohistochemistry and molecular studies may be required for evaluation. Correlation with imaging studies provides additional information that should be incorporated into the pathological interpretation. 相似文献
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Giant cell rich lesions encompass a relatively large group of biologically and morphologically diverse bone tumours. They are all related to one another by the presence of numerous multinucleated osteoclast-like giant cells. However, they differ from each other by virtue of their clinical and radiographic characteristics and in many cases, their morphology. In select cases, immunohistochemistry may be necessary to make an accurate diagnosis. The importance of correctly identifying these tumours rests on the differences in their treatment and prognosis. 相似文献
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非骨化性纤维瘤的X线平片及CT诊断(附14例报告) 总被引:4,自引:1,他引:3
目的 分析非骨化性纤维瘤的X线平片及CT表现 ,探讨其诊断价值。方法 14例中男 11例 ,女 3例 ,年龄 9~ 5 1岁 ,均经手术病理证实 ,有完整的X线、CT资料。结果 10~ 2 0岁发病最多 (占 64.3% ) ,多发生于膝关节附近、股骨及胫骨干骺区。X线表现分为两型 :皮质型 6例 ,髓腔型 8例。CT特征表现为 :( 1)局部骨皮质破坏 ;( 2 )病灶内细而短的骨嵴 ;( 3)病灶近髓腔侧有细的硬化线。结论 X线平片结合CT检查可提高NOF诊断的准确性 相似文献
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Non-ossifying fibroma or benign lipoblastoma of bone–an electron-microscopic and histochemical study
An ultrastructural and histochemical analysis was made of a lesion identified by light microscopy as a non-ossifying fibroma of bone. A histogenetic sequence was traced from spindle-shaped fibroblast-like cells to multivacuolated lipoblasts with abundant glycogen. These lipid-laden cells showed remarkable similarity to some cells of a well differentiated liposarcoma. Others have interpreted the lipid-containing cells of non-ossifying fibroma as representing fibroblasts which have imbibed or synthesized lipid or lipid-laden macrophages. Our studies demonstrate that this tumour consists of primitive mesenchymal cells with partial maturation to early lipoblasts, suggesting its classification as a benign lipoblastoma of bone. 相似文献
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《Diagnostic Histopathology》2016,22(10):397-412
We review entities that have historically been thought to be pseudotumors or mimics of bone tumours. We discuss tumifactive amyloid deposits, the brown tumours of hyperparathyroidism, the various types of cysts that can be seen in bone, Nora lesion, subungual exostosis, haemophilic pseudotumors, non-ossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, Paget disease, tophaceous gout and pseudogout. 相似文献
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Pieter J. Slootweg 《Journal of oral pathology & medicine》1989,18(3):128-132
The present investigation concerns 113 patients with peripheral giant cell granulomas, 52 patients with central giant cell granulomas and 18 patients with non-ossifying fibromas of the long bones. The purpose was to analyze the possible equivalence of central giant cell granulomas with non-ossifying fibromas. Non-ossifying fibromas occur at a lower mean age than central giant cell granulomas and moreover, although central giant cell granulomas may exhibit areas that are histologically similar to non-ossifying fibromas, the presence of other features, especially bone formation, warrants a recognition of central giant cell granulomas and non-ossifying fibromas as separate entities. 相似文献
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摘要: 非骨化性纤维瘤发病率极低, 多发生于四肢长骨距离骺板3~4 cm的干骺端, 尤以胫骨、 股骨和腓骨为多见, 但发生于髌骨者国内外鲜有报道, 本文通过分析收治的1例髌骨非骨化性纤维瘤患者的检查及手术情况, 探讨其临床表现、 病理特点及预后。 相似文献
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Carolina C Gomes Marina G Diniz Victor C Bastos Vanessa F Bernardes Ricardo S Gomez 《The Journal of pathology》2020,250(2):126-133
Next-generation sequencing has revealed mutations in several bone-related lesions and was recently used to uncover the genetic basis of giant cell lesions of the jaws (GCLJ). Consistent with their benign nature, GCLJ show a low tumor mutation burden. They also harbor somatic, heterozygous, mutually exclusive mutations in TRPV4, KRAS, or FGFR1. These signature mutations occur only in a subset of lesional cells, suggesting the existence of a ‘landscaping effect’, with mutant cells inducing abnormal accumulation of non-mutant cells that form the tumor mass. Osteoclast-rich lesions with histological similarities to GCLJ can occur in the jaws sporadically or in association with genetically inherited syndromes. Based on recent results, the pathogenesis of a subgroup of sporadic GCLJ seems closely related to non-ossifying fibroma of long bones, with both lesions sharing MAPK pathway-activating mutations. In this review, we extrapolate from these recent findings to contextualize GCLJ genetics and we highlight the therapeutic implications of this new information. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献