28例青年人胃癌的临床及病理分析

对２８例青年人胃癌的临床及病理分析结果表明，其发病具有症状隐匿、病程短、进展快的特点，本组病例从出现症状到漏诊在６个月内为５７．１％（１６例），首发症状以上腹部疼痛、吐血、黑便多见，病理特征以结节蕈伞型、高分化腺癌多见。     

农村医疗救助基金利用的影响因素与对策建议

医疗救助是政府对因患病而无经济能力诊治的贫困人群,实施专项帮助和资金资助的一种医疗保障制度。目前,全国有1501个县开展了农村医疗救助工作,初步形成了比较系统的农村医疗救助制度和框架,但是在农村医疗救助实际工作中发现,每年实际支付救助金数额与按特困人口医疗救助计划中测算的每年应支付数额相比,使用率不足50%。针对这种情况,分析影响农村医疗救助基金利用的影响因素,提出了对策建议。     

FIZZ1在炎症相关性肺动脉高压中的作用

低氧诱导促有丝分裂因子(hypoxia-induced mitogenic factor,HIMF)是一类富含半胱氨酸的分泌蛋白.HIMF首先在炎症区域被发现,并且扮演着炎症细胞标志物的角色,HIMF同时又称作发现于炎症区域1(found in inflammatory zone 1,FIZZ1).由于该蛋白家族成员在低氧与炎症相关生理病理过程中起不可忽视的作用,国内外对该蛋白家族的研究越来越多.目前该因子在血管生长、平滑肌增殖、气道炎症、肠道免疫等方面的作用已有相关研究.     

FIZZ1 Plays a Crucial Role in Early Stage Airway Remodeling of OVA-Induced Asthma

The aim of this study was to elucidate the role of Found in Inflammatory Zone 1 (FIZZ1, also known as RELM-α or resistin-like molecule-α) in airway remodeling in asthma. We used a rat model of ovalbumin (OVA) sensitization and challenge to induce lung inflammation and remodeling. Expression of α -SMA in the lungs of OVA-treated rats was significantly elevated in the peribronchial regions compared with control saline-treated animals. Expression of FIZZ1 mRNA in alveolar epithelial type II cells (AECII) isolated from OVA-treated animals was higher than in control animals. Forced expression of recombinant FIZZ1 in rat-1 lung fibroblast cell line enhanced production of collagen type I and α -SMA compared with control transfected cells. These results suggest that FIZZ1 can induce fibroblasts to express markers of myofibroblast differentiation such as α -SMA and collagen type I, which are characteristic of early stages of airway remodeling seen in asthma.     

Moderate alcohol intake and motor vehicle crashes: the conflict between health advantage and at-risk use

AIMS: To review the evidence on moderate alcohol intake and motor vehicle crash (MVC) risk, and discuss the possible public health tension in balancing risk reduction and increment with respect to moderate alcohol intake. METHOD: A Medline review was conducted on moderate alcohol intake, MVC, and cardiovascular disease (CVD) risks. RESULT: Moderate alcohol intake (24 g ethanol, two US standard drinks, or less a day) is associated with 20% reduction in risk of CVD. Public awareness of this may contribute to why rates of driving with blood alcohol content (BAC) <0.08 g/dl in the United States are static. Studies show 3- to 17-fold increased risk of a fatal MVC with BAC < 0.08 g/dl compared to sober drivers. The United States has 0.08 g/dl BAC laws, higher than that reached by a driver drinking two drinks per day or less. CONCLUSION: The public should be educated that although moderate alcohol drinking may not violate BAC laws, it still carries significant risk of MVC. Current BAC laws in some countries needs re-evaluation.     

心理测验在我国大学生心理健康评价中的应用现状及存在问题

目的　了解心理测验在我国大学生心理健康评价中的应用现状和发展趋势。方法　以 CNKI数据探索系统 (全文数据库 )为检索平台 ,标引关键词“大学生与心理健康”为检索入口词 ,检索该系统收录的 1 994～ 2 0 0 3年相关文献。结果　检索到相关文献 2 2 6篇 ,其中 90篇文献运用心理测验量表 ,使用量表的文献占 3 9.82 %。结论　心理测验作为大学生心理健康的评价工具之一已得到学校心理卫生工作者的认同和运用 ,但在使用过程中尚存在一些有待改进和完善的问题     

Loxin polymorphism is associated with increased resistin levels and with oxidative status

Objectives

We hypothesized that LOX-1 polymorphism may impact on inflammation and cardiovascular risk by modulating systemic resistin expression.

Design and methods

276 men were randomly selected from a population-based cohort. Metabolic and inflammatory markers were evaluated at baseline and after 6-years follow-up, OLR1 (loxin) IVS4-14 A>G polymorphism was assessed.

Results

Mean plasma resistin and nitrotyrosine values were significantly higher, and TAS was significantly lowered in homozygous for the G allele. The G allele was significantly and directly associated with resistin and nitrotyrosine values.

Conclusion

Enhanced oxidized-LDL uptake by LOX-1 G-allele carriers is associated with increased pro-oxidant status and resistin levels, suggesting a major uptake of ox-LDL by macrophages, smooth muscle cells, and monocytes.