全文获取类型
收费全文 | 8990篇 |
免费 | 853篇 |
国内免费 | 278篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 116篇 |
妇产科学 | 80篇 |
基础医学 | 1557篇 |
口腔科学 | 99篇 |
临床医学 | 805篇 |
内科学 | 1260篇 |
皮肤病学 | 109篇 |
神经病学 | 502篇 |
特种医学 | 334篇 |
外科学 | 660篇 |
综合类 | 785篇 |
预防医学 | 857篇 |
眼科学 | 57篇 |
药学 | 1128篇 |
1篇 | |
中国医学 | 373篇 |
肿瘤学 | 1327篇 |
出版年
2024年 | 39篇 |
2023年 | 188篇 |
2022年 | 473篇 |
2021年 | 523篇 |
2020年 | 420篇 |
2019年 | 470篇 |
2018年 | 433篇 |
2017年 | 366篇 |
2016年 | 405篇 |
2015年 | 426篇 |
2014年 | 686篇 |
2013年 | 651篇 |
2012年 | 494篇 |
2011年 | 618篇 |
2010年 | 362篇 |
2009年 | 452篇 |
2008年 | 412篇 |
2007年 | 397篇 |
2006年 | 347篇 |
2005年 | 275篇 |
2004年 | 184篇 |
2003年 | 177篇 |
2002年 | 131篇 |
2001年 | 116篇 |
2000年 | 109篇 |
1999年 | 78篇 |
1998年 | 112篇 |
1997年 | 107篇 |
1996年 | 60篇 |
1995年 | 79篇 |
1994年 | 67篇 |
1993年 | 61篇 |
1992年 | 51篇 |
1991年 | 56篇 |
1990年 | 44篇 |
1989年 | 32篇 |
1988年 | 28篇 |
1987年 | 20篇 |
1986年 | 15篇 |
1985年 | 28篇 |
1984年 | 30篇 |
1983年 | 19篇 |
1982年 | 21篇 |
1981年 | 21篇 |
1980年 | 12篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1976年 | 3篇 |
1974年 | 2篇 |
1973年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
《Saudi Pharmaceutical Journal》2022,30(11):1572-1588
Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of a metabolic syndrome caused by excessive accumulation of fat in the liver. Orthosiphon stamineus also known as Orthosiphon aristatus is a medicinal plant with possible potential beneficial effects on various metabolic disorders. This study aims to investigate the in vitro inhibitory effects of O. stamineus on hepatic fat accumulation and to further use the computational systems pharmacology approach to identify the pharmacokinetic properties of the bioactive compounds of O. stamineus and to predict their molecular mechanisms against NAFLD. Methods: The effects of an ethanolic extract of O. stamineus leaves on cytotoxicity, fat accumulation and antioxidant activity were assessed using HepG2 cells. The bioactive compounds of O. stamineus were identified using LC/MS and two bioinformatics databases, namely the Traditional Chinese Medicine Integrated Database (TCMID) and the Bioinformatics Analysis Tool for the Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Pathway enrichment analysis was performed on the predicted targets of the bioactive compounds to provide a systematic overview of the molecular mechanism of action, while molecular docking was used to validate the predicted targets. Results: A total of 27 bioactive compounds corresponding to 50 potential NAFLD-related targets were identified. O. stamineus exerts its anti-NAFLD effects by modulating a variety of cellular processes, including oxidative stress, mitochondrial β-oxidation, inflammatory signalling pathways, insulin signalling, and fatty acid homeostasis pathways. O. stamineus is significantly targeting many oxidative stress regulators, including JNK, mammalian target of rapamycin (mTOR), NFKB1, PPAR, and AKT1. Molecular docking analysis confirmed the expected high affinity for the potential targets, while the in vitro assay indicates the ability of O. stamineus to inhibit hepatic fat accumulation. Conclusion: Using the computational systems pharmacology approach, the potentially beneficial effect of O. stamineus in NAFLD was indicated through the combination of multiple compounds, multiple targets, and multicellular components. 相似文献
2.
3.
4.
John Bickle 《Topics in Cognitive Science》2015,7(2):299-311
David Marr's three-level method for completely understanding a cognitive system and the importance he attaches to the computational level are so familiar as to scarcely need repeating. Fewer seem to recognize that Marr defends his famous method by criticizing the “reductionistic approach.” This sets up a more interesting relationship between Marr and reductionism than is usually acknowledged. I argue that Marr was correct in his criticism of the reductionists of his time—they were only describing (cellular activity), not explaining (cognitive functions). But a careful metascientific account of reductionistic neuroscience over the past two decades reveals that Marr's criticisms no longer have force. Contemporary neuroscience now explains cognition directly, although in a fashion—causal-mechanistically—quite different than Marr recommended. So while Marr was correct to reject the reductionism of his day and offer an alternative method for genuinely explaining cognition, contemporary cognitive scientists now owe us a new defense of Marr's famous method and the advantages of its explanations over the type now pursued successfully in current reductionist neuroscience. There are familiar reasons for thinking that this debt will not be paid easily. 相似文献
5.
6.
HER2-positive (HER2+) breast cancer (BC) is a heterogenous and multifaceted disease, with interesting therapeutic implications. First, all intrinsic molecular subtypes can be identified in HER2+ tumors, with the HER2-enriched being the most frequent. Such subtypes do not differ much from their counterparts in HER2-negative disease, apart for the high expression of genes in/near the HER2 amplicon on chromosome 17. Intrinsic subtyping, along with the quantification of ERBB2 mRNA levels, is associated with higher rates of pathologic complete response across neoadjuvant trials of dual HER2 blockade and might help select patients for de-escalation and escalation treatment strategies. Secondly, HER2+ tumors have a broad range of DNA alterations. ERBB2 mutations and alterations in the PI3K/Akt/mTOR pathway are among the most frequent and might predict benefit from potent pan-HER, PI3K and mTOR inhibitors. Moreover, HER2+ tumors are usually infiltrated by lymphocytes. These tumor infiltrating-lymphocytes (TILs) predict response to neoadjuvant anti-HER2-based treatment and exert a prognostic role. PD-L1, detected in ∼42 % of HER2+ BC, might also be useful to define patients responding to novel anti-PD1/PD-L1 immunotherapies. New multiparametric clinicopathologic and genomic tools accounting for this complexity, such as HER2DX, are under development to define more tailored treatment approaches. Finally, HER2-targeted antibody-drug conjugates (ADC) such as trastuzumab deruxtecan might be active in tumors with low expression of HER2. Overall, there is a need to molecularly characterize and develop novel targeted therapies for HER2+ disease. 相似文献
7.
《Clínica e investigación en ginecología y obstetricia》2022,49(2):100740
Preeclampsia is a disease with a significant incidence worldwide that is directly associated with 15% of maternal deaths. This is usually characterized by the presence of hypertension and proteinuria, which manifests itself from the middle of pregnancy. MicroRNAs are single-stranded RNA molecules that act primarily by degrading transcribed messenger RNA or inhibiting microRNA translation. Placental microRNAs play a role in the growth and function of the placenta, their potential use as diagnostic biomarkers is considered feasible due to the ability to enter the maternal circulation and be detectable in maternal plasma. 相似文献
8.
9.
Systemic anticancer therapy for hepatocellular carcinoma (HCC) is limited by intrinsic drug resistance and accompanying liver
dysfunction. However, recent advances in molecular targeted therapy (MTT) have shed light on the treatment of advanced HCC.
A recent randomized, placebo-controlled trial demonstrated that sorafenib, a multi-target tyrosine kinase inhibitor, prolonged
overall survival and time-to-progression in patients with advanced HCC. This breakthrough highlights the potential of MTT
targeting hepatocarcinogenic pathways, such as the Raf/MAPK/ERK pathway, angiogenic pathways and the EGFR signaling pathway.
This review discusses the current status and the potential of developing novel MTTs for advanced HCC. 相似文献
10.
Abstract: We describe the use of restriction analysis on PCR-amplified DNA for detecting all B*27 subtypes except B*2710 and B*2711 (i.e. from B*2701 to B*2709). After detecting B*27 by Sty I, double digestions consisting of Sty I plus another informative enzyme led to subtype assignment. We used mismatched primers to create restriction sites when necessary. The method avoids group-specific amplifications and other laborious optimization procedures. It was successfully tested on a panel of well characterized cell lines covering different B*27 subtypes. Then, we studied a group of 57 ankylosing spondyiitis patients and 746 controls from the south of Spain. B*27 showed a very strong association with the disease (OR=211.27, P=\0˜7). B*2702 and B*2705 distribution in controls (20% and 77.1%, respectively) differed from previously reported data in the Spanish population. We unexpectedly found the B*2707 allele in our population (one control). 相似文献