联合应用纳络酮、尿激酶及低分子肝素治疗急性脑梗塞的临床研究

目的：本文联合应用纳诺酮,尿激酶及低分子肝素治疗３５例急性脑梗塞（ＡＣＩ）患者（治疗组）,观察其治疗前后的β－内啡肽（β－ＥＰ）改变及临床疗效。方法：并与３０例常规药物治疗组（对照组）比较。结果：结果显示,两组患者的血浆β－ＥＰ浓度均明显高于正常组,治疗组治疗后,其β－ＥＰ浓度显著下降,临床疗效明显高于对照组。提示纳络酮能明显降低（ＡＣＩ）患者的血浆β－ＥＰ浓度。结论三药联合应用的临床疗效明显优于     

Le lithium chez le sujet bipolaire âgé

Regarding the burden of mental disorders in elderly patients, including morbidity and mortality, especially by suicide, and impairment of quality of life and functional autonomy, there is a need to take into account special health care needs of elderly persons. In bipolar disorders, lithium tends to be under-prescribed in elderly patients, while it is still a first line choice in guidelines. If it is true that there is a lack of controlled studies on effectiveness of lithium in elderly patients, available data from lithium side effects, especially on renal function, don’t justify this under-utilization. Moreover, anti-inflammatory and neuroprotective effects of lithium may be of particular interest in ageing, in preventing and/or controlling the occurrence of some neurodegenerative process.     

Cosmétovigilance en 2007

Cosmetics are products, which by definition “…must not damage human health in the normal conditions of use”. However, unwanted effects do occur, the best known being cutaneous and allergic reactions. The dermatology-allergy specialist is thus the first to be concerned with cosmetovigilance. In 1966, the Groupe d’études et de recherche en dermato-allergologie (GERDA) created a vigilance network concerned with cutaneous allergic incidents [Réseau de vigilance sur les accidents allergiques cutanés (REVIDAL)], the REVIDAL GERDA, which acts as a coordinator for cosmetovigilance. In 2004, a public cosmetovigilance committee was created; all serious adverse effects or those appearing to be serious were to be reported immediately to the Agence française de sécurité sanitaire des produits de santé (AFSSAPS) by health professionals who observed them. Manufacturers are required to participate in this public cosmetovigilance. They have a similar responsibility via the Direction générale de la concurrence et de la consommation (DGCCRF) to report to AFSSAPS the list of their products which contain substances for which there is a serious doubt. This means that cosmetovigilance requires collection of cases; it will work well only if reports are made regularly. The physician who reports cases improves the management of his patients and participates in Public Health actions. This type of cosmetovigilance will extend to all EU countries. Reports by consumers should be possible, but they will be encouraged to consult a doctor before doing so.     

Gardasil®-induced erythema nodosum

Erythema nodosum is a panniculitis occurring more frequently in young women. We report a 16-year-old woman who presented with erythema nodosum that occurred following Gardasil^® administration (vaccine against HPV types 6, 11, 16 and 18) and that is proposed to young female. This adverse effect is not a contraindication to the HPV vaccination because its benefit against the oncogene risk of Papillomavirus is documented.     

心先安治疗病窦综合征34例疗效观察

目的观察新型腺苷类化合物心先安治疗病态窦房结综合征的l临床价值。方法选择34例病窦综合征患者，给予心先安120mg＋5％葡萄糖注射液250ml静脉应用，每日1次，连用14天，观察治疗前后病人自觉症状及心率的改善情况。结果显效24例，有效6例，无效4例，总有效率为89．8％。结论心先安疗效确切，副作用小，安全范围大，值得在临床上选择使用。