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Identification of the C-terminal flanking peptide of preprocholecystokinin in rat brain by a novel radioimmunoassay 总被引:1,自引:0,他引:1
The C-terminal flanking peptide of preprocholecystokinin (preproCCK) has been identified in extracts of rat brain using a novel radioimmunoassay. There is a single form of immunoreactive material on gel filtration, ion exchange and reversed-phase HPLC. The C-terminal preproCCK immunoreactivity had a similar pattern of distribution to CCK8 in different regions of rat brain. This assay should help in studies of neuronal CCK biosynthesis. 相似文献
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用原位杂交法研究大鼠脑损伤后胆囊收缩素和脑啡肽mRNA量的变化 总被引:2,自引:0,他引:2
应用原位杂交技术,研究大鼠脑损伤后前胆囊收缩素(PCCK)和前脑啡肽原(PPE)mRNA的表达。结果表明,在大鼠脑损伤24h后同侧脑内PCCK和PPEmRNA量增加,尤其以新皮质和海马显著。给予NMDA受体非竞争性拮抗剂ketamine可以抑制增加。因此,作者认为在脑损伤后可诱发胆囊收缩素(CCK)和脑啡肽(ENK)合成增加,并参与脑损伤病理改变,另外这种合成增加可能由NMDA受体介导。 相似文献
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