全文获取类型
收费全文 | 1603篇 |
免费 | 126篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 239篇 |
儿科学 | 35篇 |
妇产科学 | 3篇 |
基础医学 | 61篇 |
口腔科学 | 7篇 |
临床医学 | 324篇 |
内科学 | 422篇 |
皮肤病学 | 1篇 |
神经病学 | 308篇 |
特种医学 | 22篇 |
外科学 | 14篇 |
综合类 | 192篇 |
预防医学 | 21篇 |
眼科学 | 5篇 |
药学 | 85篇 |
1篇 | |
中国医学 | 32篇 |
肿瘤学 | 9篇 |
出版年
2024年 | 3篇 |
2023年 | 23篇 |
2022年 | 42篇 |
2021年 | 65篇 |
2020年 | 75篇 |
2019年 | 46篇 |
2018年 | 51篇 |
2017年 | 100篇 |
2016年 | 62篇 |
2015年 | 54篇 |
2014年 | 88篇 |
2013年 | 109篇 |
2012年 | 88篇 |
2011年 | 71篇 |
2010年 | 54篇 |
2009年 | 56篇 |
2008年 | 51篇 |
2007年 | 60篇 |
2006年 | 67篇 |
2005年 | 49篇 |
2004年 | 50篇 |
2003年 | 57篇 |
2002年 | 57篇 |
2001年 | 34篇 |
2000年 | 40篇 |
1999年 | 45篇 |
1998年 | 21篇 |
1997年 | 29篇 |
1996年 | 23篇 |
1995年 | 24篇 |
1994年 | 19篇 |
1993年 | 16篇 |
1992年 | 12篇 |
1991年 | 8篇 |
1990年 | 11篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 12篇 |
1986年 | 18篇 |
1985年 | 9篇 |
1984年 | 15篇 |
1983年 | 9篇 |
1982年 | 5篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1978年 | 8篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1973年 | 1篇 |
排序方式: 共有1781条查询结果,搜索用时 15 毫秒
1.
Paolo Mazzone Fabrizio Stocchi Salvatore Galati Angelo Insola Maria Grazia Altibrandi Nicola Modugno Domenicantonio Tropepi Livia Brusa Alessandro Stefani 《Neuromodulation》2006,9(3):221-228
Objectives. Traditional deep brain stimulation (DBS) at the subthalamic nucleus (STN) has proved to be efficacious on core Parkinsonian symptoms. However, very disabling l ‐dopa–induced abnormal involuntary movements (AIMs) and axial signs are slightly affected, suggesting that we target less conventional targets. Our candidates for DBS were the globus pallidus internus (GPi) plus the intralaminar thalamic complex (Pf or CM), given its extensive functional links with basal ganglia nuclei. Materials and Methods. The routine utilization of our innovative stereotactic apparatus allows us to implant, at the same time, both the CM‐Pf complex together with the GPi in six Parkinson disease patients. Both intraoperative and postoperative neurophysiologic assessments helped us recognize functional subregions while optimizing implantation of electrodes. Unified Parkinson disease rating scale (UPDRS) motor scores, AIMs, and freezing were carefully blindly evaluated for each condition. Results. A significant amelioration of UPDRS scores was achieved by simultaneous activation of both targets. CM‐Pf activation was only slightly effective in reducing rigidity and akinesia, but more efficacious on freezing. Not surprisingly, AIMs were peculiarly decreased by the activation of the permanent electro‐catheter in the posteroventral GPi. Conclusions. These findings confirm that, in selected patients, it is conceivable to target structures other than the conventional STN in order to maximize clinical benefit. 相似文献
2.
Paroxysmal dyskinesias (PxDs) are involuntary, episodic movements that include paroxysmal kinesigenic (PKD), paroxysmal nonkinesigenic (PNKD), and paroxysmal hypnogenic (PHD) varieties. Although most PxDs are primary (idiopathic or genetic), we found 17 of our 76 patients with PxD (22%) to have an identifiable cause for their PxD (10 men; mean age, 41.4 years). Causes included peripheral trauma (in three patients), vascular lesions (in four), central trauma (in four), kernicterus (in two), multiple sclerosis (in one), cytomegalovirus encephalitis (in one), meningovascular syphilis (in one), and migraine (in one). The latency from insult to symptom onset ranged from days (trauma) to 18 years (kernicterus), with a mean of 3 years. Nine patients had PNKD, two had PKD, five had mixed PKD/PNKD, and one had PHD. Hemidystonia was the most common expression of the paroxysmal movement disorder, present in 11 patients. Both of the patients with PKD had symptom durations of <5 minutes. Symptom duration ranged from 10 seconds to 15 days for PNKD and from 5 minutes to 45 minutes for mixed PKD/PNKD. There were no uniformly effective therapies, but anticonvulsant drugs, clonazepam, and botulinum toxin injections were the most beneficial. Awareness of the variable phenomenology and the spectrum of causes associated with secondary PxD will allow for more timely diagnosis and early intervention. 相似文献
3.
4.
Alain Djacoba Tehindrazanarivelo Jean Marc Visy Marie-Germaine Bousser 《Cephalalgia : an international journal of headache》1992,12(5):318-320
We report two patients with ipsilateral attacks of cluster headache and chronic paroxysmal hemicrania. The first patient, a 33-year-old man, started having attacks of chronic cluster headache at the age of 27. At 33, they were replaced by typical attacks of ipsilateral chronic paroxysmal hemicrania which showed a dramatic improvement with indomethacin 150 mg daily. After two days of complete remission, cluster headache attacks reappeared and persisted until verapamil, 360 mg a day, was added to indomethacin. The second patient, a 45-year-old man, first developed attacks of episodic cluster headache at the age of 35. At 44, he experienced ipsilateral typical attacks of chronic paroxysmal hemicrania, and two months later attacks of cluster headache. Under verapamil 240 mg daily, attacks of cluster headache disappeared, but those of chronic paroxysmal hemicrania increased in frequency until indomethacin 150 mg daily was added. These observations suggest a close relationship but not a similarity between cluster headache and chronic paraoxysmal hemicrania, and show the practical therapeutic interest of maintaining this distinction. 相似文献
5.
本文分析了20例PNH患者红细胞膜总脂,Ch/PIM比及磷脂组分,并比较了10例PNH红细胞膜AChE在PBS系统和生理盐水中的酶活性。发现PNH红细胞膜脂缺失严重,比正常少22%,但Ch/PIM比值及各磷脂相对含量均无明显改变。在PBS中AChE活性接近正常红细胞,但在生理盐水中明显低于正常红细胞,仅为正常的40%。表明PNH红细胞对补体敏感而溶血可能是由于补体导致膜脂缺失,进而破坏了红细胞膜结构的完整性而引起的,这也是AChE活性在低pH环境中酶活性比正常红细胞低的原因。 相似文献
6.
J. D. Schaafsma Y. Balash T. Gurevich A. L. Bartels J. M. Hausdorff N. Giladi 《European journal of neurology》2003,10(4):391-398
To assess the effect of levodopa on distinct freezing of gait (FOG) subtypes in patients with 'off' FOG. Nineteen patients (12 men, mean age 62.0 +/- 8.4 years) with Parkinson's disease and clinically significant FOG during 'off' states were videotaped whilst walking 130 m during 'off' and 'on' states. Three independent observers characterized the type, duration, and clinical manifestations and quantified FOG by analyzing the videotapes. Their combined mean scores were used for statistical analysis. The intra-class correlation coefficient assessed inter-observer reliability. Wilcoxon and Friedman tests evaluated differences in mean frequencies of FOG characteristics. During 'off' states, FOG was elicited by turns (63%), starts (23%), walking through narrow spaces (12%) and reaching destinations (9%). These respective values were only 14, 4, 2 and 1% during 'on' states (P < 0.011). Moving forward with very small steps and leg trembling in place were the most common manifestations of FOG; total akinesia was rare. Most FOG episodes took <10 s and tended to be shorter during 'on' states. Levodopa significantly decreased FOG frequency (P < 0.0001) and the number of episodes with akinesia (P < 0.001). Distinction amongst FOG subtypes enables evaluation of distinctive therapeutic response. Levodopa helps in reducing the frequency and duration of 'off'-related FOG. 相似文献
7.
目的 比较阵发性睡眠性血红蛋白尿症(PNH)患者血细胞表面3种糖基化磷脂酰肌醇(GPI)锚定蛋白表达情况。方法 流式细胞术检测25例PNH患者粒细胞表面GPI锚定蛋白CD55、CD59和CD87的表达水平,并分析它们在不同疾病状态下的改变。结果 PNH患者粒细胞表面3种GPI锚定蛋白间具有较好的相关性(P均<0.05),红细胞表面CD55和CD59也表现出相关(P<0.01),但与粒细胞表面CD55和CD59的缺乏情况并不一致。结论 PNH患者同一系血细胞表面GPI锚定蛋白呈平行关系,这有助于对PNH发病机制的进一步了解。 相似文献
8.
The suspicion of a diagnosis of Rett syndrome (RTT) is based on clinical criteria that are often not present in the first two stages of the disease, as many of its symptoms will appear at a later age. This sometimes postpones the genetic diagnosis and an early clinical intervention. We present the case of 19-months-old girl who came to the consultation because of an arrest of psychomotor development noticed 5 months earlier without change in sleep pattern, behavior, or social communication. In the observation of 1 hour videotape, she presented subtle stereotypic movements of the face and hands as well as repetitive dystonic posturing of her limbs. A genetic test confirmed the diagnosis of RTT, showing a truncating mutation in the MECP2 gene (R270X). This case confirms that stereotypic movement anomalies, albeit infrequent and subtle, are already present before the regression stage and while maintaining prehension and that, in addition, repetitive dystonic postures may occur. Recognition of these early movement disorders will improve clinicians' ability to perform an earlier diagnosis of RTT. 相似文献
9.
同时性后半规管与水平半规管性良性位置性眩晕 总被引:6,自引:1,他引:5
目的:探讨同时性后半规管与水平半规管性良性位置性眩晕(混合性良性位置性眩晕)的诊治方法。方法:联合应用Epley手法和Barbecue翻滚法对4例患者进行治疗,两次治疗间隔1d。结果:4例患者眩晕症状完全消失,随访至今无复发。结论:混合性良性位置性眩晕兼有后半规管与水平半规管性良性位置性眩晕的临床表现,联合采用Epley手法和Barbecue翻滚法治疗该病是可行的。 相似文献
10.
The development of paroxysmal nocturnal haemoglobinuria (PNH) requires two coincident factors: somatic mutation of the PIG-A gene in one or more haemopoietic stem cells and an abnormal, hypoplastic bone marrow environment. When both of these conditions are met, the fledgling PNH clone may flourish. This review will discuss the pathophysiology of this disease, which has recently been elucidated in some detail. 相似文献