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K. E. Anderson A. M. Dart E. A. Woodcock 《Clinical and experimental pharmacology & physiology》1994,21(2):141-144
1. Global myocariial ischaemia (MI) for periods greater tan 5 min caused an inhibition of phosphatidylinositol specific phospholipase C (PtdIns-PLC) activity. 2. Two min reperfusion following a 20 min MI period, a time point associated with reperfusion-induced arrhythmias, resulted in an activation of PtdIns-PLC activity, dependent on endogenous noradrenaline and mediated via al-adrenoceptors. 3. This 2 min reperfusion response, in contrast to healthy myocardium, resulted in: (i) enhanced PtdIns-PLC activity; (ii) increased sensitivity to endogenous noradrenaline; (iii) rapid increases in inositol(1,4,5)trisphosphate (Ins(1,4,5)P3); and (iv) PLC hydrolysis primarily of PtdIns(4,5)P<sub>2</sub>, such that the majority of InsP isomers derive from Ins(1,4,5)P<sub>3</sub>. 4. Together, these data suggest a functional role for Ins(1,4,5)P3 under postischaemic reperfusion conditions, and provide a possible link between al-adrenoceptor stimulation of the PtdIns turnover pathway and reperfusion injury. 相似文献
6.
M. Turgut 《Acta neurochirurgica》2007,149(10):1063-1069
Summary
<i>Background.</i> Şerefeddin Sabuncuoğlu (A.D. 1385–1468) was the author of the first illustrated surgery atlas Cerrahiyyetü’l Haniyye (Imperial
Surgery), which was written in Turkish in 1465. The purpose of this report is to present his unique contribution to modern
neurological surgery.
<i>Methods.</i> Cerrahiyyetü’l Haniyye consists of 412 pages in three chapters, in which there are a total of 191 sections dealing with a
variety of surgical specialties, including neurosurgery. In each section of the book, a sentence written in rhyme and meter
gives the diagnosis, classification and surgical technique in detail. Şerefeddin Sabuncuoğlu describes medical and surgical
management of neurological diseases such as spinal trauma, epilepsy, migraine, facial palsy, hemiplegia, low back pain, cranial
fracture, hydrocephalus and abscesses of the head in his textbook.
<i>Conclusions.</i> Şerefeddin Sabuncuoğlu was a great surgeon in Turkish medical history and the sections on neurological diseases in Cerrahiyyetü’l
Haniyye are of great importance in neurosurgery. Today, he is justified as a pioneer of surgery, an investigator and a medical
illustrator in the early period of Ottoman Empire. His atlas is a modification of original contributions from earlier treatises. 相似文献
7.
利用人T淋巴母细胞(Jurkat)细胞系作为研究对象。企图探探索细胞外基质成份及肌醇磷脂细胞信息传递系统与细胞移动的关系。研究结果表明:当细胞被伏波醇酯(PMA)处理过后,其粘连性与移动件对纤维连结蛋白(FN)底物的反应在已是高水平的基础上有更进一步提高的作用。与FN刊相反的是,未经PMA处理处的Jurkat细胞对层粘连蛋白(Lm)底物却无明显的粘连性及移动性增加的反应,尽管在PMA处理过4小时内亦无任何的增强。但是,当PMA作用于细胞24一48小时后则明显池增加其Lm底物的粘连性及移动性反应,表明了其明显的协同作用。分别用抗FN、抗Lm及蛋白激酶C抑制剂Staurosprine(SP)时均起到特异性的抑制作用。可见,协同作用的产生是通过蛋白激酶C激活后的-段时间内,使细胞表面Lm受体密度增加而对底物Lm反应增强所致。 相似文献
8.
Ryozo Oishi Yoshinori Itoh Tamotsu Fukuda Yasunori Araki Kiyomi Saeki 《Journal of neural transmission (Vienna, Austria : 1996)》1988,73(1):65-69
Summary The size of the neuronal and non-neuronal histamine pools in the brain of three different strains of rats was measured by assuming that the <img src="/content/l072557712553u57/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-fluoromethylhistidine-induced maximal decrement of histamine represents the size of the neuronal pool. Although the total histamine levels in the brain showed a considerable interstrain variation, no significant interstrain difference was observed in the neuronal histamine level. These results suggest that the size of the neuronal histamine pool in the brain is relatively stable, whereas the size of the non-neuronal histamine pool is variable. 相似文献
9.
S. -L. Brown D. S. Charney S. W. Woods G. R. Heninger J. Tallman 《Psychopharmacology》1988,94(1):24-28
Lymphocyte beta adrenergic receptor binding using [<sup>125</sup>I]CNP was determined in patients with panic disorder (<i>N</i>=4) or agoraphobia with panic attacks (<i>N</i>=17) and age- and sex-matched healthy subjects (<i>N</i>=22). The patients showed a significantly lower number of <img src="/content/wu4260l3781wn4j4/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-adrenergic receptor binding sites and a significantly higher affinity of binding than healthy subjects. A past or present history of major depression in the patients did not alter these findings. These results are consistent with a growing body of knowledge implicating noradrenergic dysfunction in the pathophysiology of panic anxiety. 相似文献
10.
Five aliphatic 5<img src="/content/l6444461378u1m1u/xxlarge8242.gif" alt="prime" align="BASELINE" BORDER="0">-esters of 5-iodo-2<img src="/content/l6444461378u1m1u/xxlarge8242.gif" alt="prime" align="BASELINE" BORDER="0">deoxyuridine (IDU) were synthesized via an acid chloride alcoholysis reaction. The solubility in pH 7.4 phosphate buffer, lipophilicity as determined by partition experiments in octanol/pH 7.4 buffer, and cytotoxicity of these potential prodrugs were evaluated. The esters showed a 43- to 250-fold increase in lipophilicity and a 1.6- to 14-fold decrease in aqueous solubility relative to IDU. At a concentration of 50 µ<i>M</i>, all esters showed reduced cytotoxicity toward uninfected Vero cells relative to IDU. 相似文献