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排序方式: 共有666条查询结果,搜索用时 906 毫秒
1.
傅海燕 《中国中医基础医学杂志》2003,9(12):48-50
《素问》用“俞”,《灵枢》用“输”与“腧”表示腧穴,三字用法基本相同。“俞”源于用船运送,“输”源于用车运送,均引申为转运气血的穴位。“腧”是“俞”的今字,其字形代表的意义最符合中医学中腧穴的含义。应以“腧”作为规范的词语,表示腧穴的各种意义。 相似文献
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Philip Eisermann Dennis Rubbenstroth Daniel Cadar Corinna Thom-Bolduan Petra Eggert Alexander Schlaphof Frank Leypoldt Martin Stangel Thorsten Fortwngler Florian Hoffmann Andreas Osterman Sabine Zange Hans-Helmut Niller Klemens Angstwurm Kirsten Prtner Christina Frank Hendrik Wilking Martin Beer Jonas Schmidt-Chanasit Dennis Tappe 《Emerging infectious diseases》2021,27(5):1371
Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of encephalitis cases in Germany during 2018–2020 by using a serologic testing scheme applied along proposed graded case definitions for VSBV-1, BoDV-1, and unspecified bornavirus encephalitis. Of 103 encephalitis cases of unknown etiology, 4 bornavirus infections were detected serologically. One chronic case was caused by VSBV-1 after occupational-related contact of a person with exotic squirrels, and 3 acute cases were caused by BoDV-1 in virus-endemic areas. All 4 case-patients died. Bornavirus etiology could be confirmed by molecular methods. Serologic testing for these cases was virus specific, discriminatory, and a practical diagnostic option for living patients if no brain tissue samples are available. This testing should be guided by clinical and epidemiologic suspicions, such as residence in virus-endemic areas and animal exposure. 相似文献
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《Genetics in medicine》2023,25(11):100936
Genome sequencing can generate findings beyond the initial test indication that may be relevant to a patient or research participant’s health. In the decade since the American College of Medical Genetics and Genomics published its recommendations for reporting these findings, consensus regarding terminology has remained elusive and a variety of terms are in use globally. We conducted a scoping review to explore terminology choice and the justifications underlying those choices. Documents were included if they contained a justification for their choice of term(s) related to findings beyond the initial genomic test indication. From 3571 unique documents, 52 were included, just over half of which pertained to the clinical context (n = 29, 56%). We identified four inter-related concepts used to defend or oppose terms: expectedness of the finding, effective communication, relatedness to the original test indication, and how genomic information was generated. A variety of justifications were used to oppose the term “incidental,” whereas “secondary” had broader support as a term to describe findings deliberately sought. Terminology choice would benefit from further work to include the views of patients. We contend that clear definitions will improve ethical debate and support communication about genomic findings beyond the initial test indication. 相似文献
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目的探讨老年冠心病患者的益处发现体验。方法 2016年12月至2017年1月,采用目的抽样法选取上海市某三级甲等医院心内科收治的老年冠心病患者11例为研究对象。采用现象学研究方法,对其进行半结构访谈,采用Colaizzi 7步分析法分析访谈资料,提炼出主题。结果患者的益处发现表现为感恩、新的生活哲学、新的可能性、领悟社会支持、健康相关行为改变及利他行为等6个主题。结论医护人员应该具有心理护理的相关知识,能够识别患者益处发现的表现,可以通过增加患者对疾病的认知,改变患者的行为,从而促进患者体验到更多的益处发现,进而促进患者良好的心理适应,提高其遵医依从性,改善身心健康。 相似文献
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A flexible and simple Bayesian decision‐theoretic design for dose‐finding trials is proposed in this paper. In order to reduce the computational burden, we adopt a working model with conjugate priors, which is flexible to fit all monotonic dose‐toxicity curves and produces analytic posterior distributions. We also discuss how to use a proper utility function to reflect the interest of the trial. Patients are allocated based on not only the utility function but also the chosen dose selection rule. The most popular dose selection rule is the one‐step‐look‐ahead (OSLA), which selects the best‐so‐far dose. A more complicated rule, such as the two‐step‐look‐ahead, is theoretically more efficient than the OSLA only when the required distributional assumptions are met, which is, however, often not the case in practice. We carried out extensive simulation studies to evaluate these two dose selection rules and found that OSLA was often more efficient than two‐step‐look‐ahead under the proposed Bayesian structure. Moreover, our simulation results show that the proposed Bayesian method's performance is superior to several popular Bayesian methods and that the negative impact of prior misspecification can be managed in the design stage. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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ObjectiveThe K6 and K10 are well-validated screening measures for psychological distress and are widely used. However, the accuracy of these scales in identifying common mental disorders may be suboptimal. This study aimed to develop a brief scale of psychological distress—the Distress Questionnaire-5 (DQ5)—and validate its diagnostic accuracy in identifying common mental disorders, relative to the K6 and K10.Study Design and SettingThe DQ5 was developed from a pool of 347 items reflecting a range of mental health symptoms. Validation of the DQ5 was conducted concurrently, on the basis of DSM-5 criteria for seven common mental disorders. A population-based sample of Australian adults (n = 3,175) was recruited online, with data weighted to reflect population estimates of disorder prevalence, age, and gender.ResultsAt specified cut points, the DQ5 was significantly more accurate in identifying individuals who met criteria for each of the disorders examined relative to the K6, with the exception of major depression where there was no significant difference in sensitivity or specificity.ConclusionThe DQ5 is a promising tool for identifying psychological distress in the community, with potential for use in a range of clinical settings. 相似文献
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《Journal of the American College of Radiology》2016,13(7):764-767
The authors explore the benefits and risks of not reporting imaging findings that do not have clinical relevance, with the goal of developing recommendations to reduce their reporting. The authors review the example of incidentally detected, simple renal cysts (Bosniak category I), including medicolegal conditions required for such a shift in reporting practices to be acceptable. The authors propose four potential criteria for not reporting clinically unimportant findings and recommend that these criteria be debated in other contexts, so that they can be refined and implemented. 相似文献
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