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排序方式: 共有751条查询结果,搜索用时 15 毫秒
1.
2.
目的 观察可达龙 (胺碘酮 )加小剂量地高辛对部分经冠脉造影确诊的高血压性心脏病 (高心病 )与冠心病患者心房颤动 (房颤 )转复窦性心律的可能与安全性。方法 符合入选条件、住院连服 2周可达龙 (0 .2g,3/d)未复律的高心病、冠心病并房颤患者 32例 ,加服地高辛 0 .1 2 5g ,2 /d ,2周后为观察终点 ,判断其房颤转复成功率与用药安全性 ;并随访半年 ,观察房颤复发率。结果 32例中转复窦性心律 2 3例 ,转复率 71 .9% ,平均转复时间 (7± 2 )d ,无一例出现药物副作用 ;随访半年 ,复发 6例 ,复发率占复律者的 2 6 .1 %。结论 可达龙加小剂量地高辛对高心病、冠心病患者的房颤转复窦性心律 ,具有疗效较高 ,安全性与依从性好等优点 ,但仍有一定的复发率。 相似文献
3.
L Santoro F Barbieri R Nucciotti F Battaglia F Crispi M Ragno P Greco G Caruso 《Muscle & nerve》1992,15(7):788-795
Amiodarone was injected endoneurially at increasing doses into the exposed tibial nerve of rats to study its electrophysiologic and pathologic effects on peripheral nerve fibers. Forty-five male Wistar rats were used, and each of the following concentrations was injected into 15 nerves: 25 micrograms/mL, 50 micrograms/mL, and 100 micrograms/mL. Microinjection of a 25 micrograms/mL concentration of amiodarone resulted in a subacute, incomplete conduction block evident at day 3 postinjection. This conduction block remained stable until day 10 and recovery was complete at day 35. Microinjection of a 50 micrograms/mL concentration of amiodarone produced a faster evolving conduction block, and significant axon degeneration (approximately 40% of fibers). Injection of a 100 micrograms/mL concentration resulted in severe acute motor axon degeneration followed by complete but delayed regeneration. Results of morphological studies closely correlated with electrophysiological findings. Amiodarone thus seems to have a direct toxic effect on axons at high concentrations in the peripheral nerve, and we suggest that different pathological changes described in human amiodarone neuropathy could be related to different concentrations of the drug in the nerve, perhaps due to variability of blood-nerve barrier efficacy. 相似文献
4.
Single intravenous bolus doses of amiodarone hydrochloride of 30, 60, 90 and 120 mg/kg were administered to male Sprague-Dawley rats to determine the effects of dose on amiodarone pharmacokinetics. Serial blood samples and total urine were collected over 48 hr and assayed for amiodarone and desethylamiodarone by HPLC. The blood amiodarone concentration-time curves for the four doses were best described by a triexponential equation with terminal half-lives (t
1/2
) ranging from 17 to 20 hr. Over the dose range studied, no changes in , t
1/2
, or central compartment volume (Vc=1.2–1.4 L/kg) were observed. On the other hand, reductions in amiodarone clearance (CL and steady-state volume of distribution (V
ss
of 44% (17.7 to 10.0 ml/min per kg) and 50% (16.4 to 8.2 L/kg), respectively, were noted as the dose of amiodarone increased. The conversion of amiodarone to desethylamiodarone (fm was dose-independent and amounted to approximately 10% of each amiodarone dose. No amiodarone or desethylamiodarone was detected in the urine of any of the treated animals. The blood-to-plasma concentration ratio of amiodarone was concentration-independent and therefore did not account for the dose-dependent changes in Vss
and CL observed. The data suggested that the dose-dependent changes noted were due to an alteration in the volume (s) of the peripheral tissue compartment(s).Supported by a Grant-in-Aid from the American Heart Association, Nebraska Affiliate. 相似文献
5.
目的观察正常及模拟“缺血”时胺碘酮对绵羊心室浦肯野纤维起搏离子流(If)的影响。方法双微电极电压钳制术,使膜电位过度极化以激活If。结果胺碘酮1×10-5mol/L在正常台氏液中显著降低浦肯野纤维If幅值;模拟“缺血”也使If幅值降低,在此基础上,胺碘酮使If幅值进一步减小,加剧了“缺血”对If离子流的抑制作用。结论提示胺碘酮能抑制心肌缺血时心室正常自律性活动。 相似文献
6.
目的探讨兔缺血再灌注纤溶活性、内皮血管活性物质的变化及胺碘酮的影响。方法新西兰大白兔60只,随机分为5组,每组12只,Ⅰ组:假手术组,Ⅱ组:急性心肌梗死(acutemyocardialinfarction,AMI)组,Ⅲ组:缺血再灌注(ischemicreperfusion,IR)组,Ⅳ组:IR+利多卡因组,Ⅴ组:IR+胺碘酮组;各组(除Ⅰ组外)分别结扎冠状动脉左室支中点,缺血60min,再灌注240min(Ⅰ,Ⅱ组不进行再灌注),分别取结扎前、再灌注前、再灌注240min血测定内皮素(endochelin,ET)、一氧化氮(nitricoxideNO)浓度和组织型纤溶酶原激活剂(tissuetypeplasminogenactivator,tPA)、纤溶酶原激活剂抑制物(plasminogenactivatorinhibitorPAI)活性。结果冠状动脉结扎后,血浆ET,NO浓度和PAI活性显著高于结扎前(P<0.01),tPA活性显著低于结扎前(P<0.01),再灌注后,血浆ET,NO浓度和PAI活性进一步升高,tPA活性进一步下降,与再灌注前对比均有显著性差异(P<0.01)。再灌注后,与IR组对比,胺碘酮能显著降低血PAI活性和ET浓度(P<0.01);利多卡因组无显著变化。结论胺碘酮可抑制缺血再灌注过程中PAI活性、抑制内皮细胞释放ET的有益作用。 相似文献
7.
8.
目的 研究稳心颗粒联合胺碘酮和培哚普利治疗老年阵发性心房颤动的临床效果和安全性.方法 心内科治疗的老年阵发性心房颤动患者116例,随机分为对照组和观察组,每组58例.对照组使用胺碘酮联合培哚普利治疗,观察组有对照组的基础上加用稳心颗粒治疗.比较2组患者治疗后的效果和不良反应等.结果 观察组有效率为90.57%,对照组有效67.27%,2组差异有统计学意义(P<0.05).2组心率、房颤次数、左心室舒张末内径(LVEDD)、左心房内径(LAd)、左心房最大容积(LAVmax)、P波最大时限(Pmax)、P波离散度(Pd)、A峰峰值流速(VA),治疗前差异无统计学意义(P>0.05),治疗后,观察组与治疗前差异有统计学意义(P<0.05),对照组除左心房内径(LAd)之外与治疗之前差异均有统计学意义(P<0.05).观察组不良反应3例,不良反应发生率为5.45%,对照组不良反应15例,不良反应发生率为28.30%,差异有统计学意义(P<0.05).结论 使用稳心颗粒联合胺碘酮和培哚普利治疗老年阵发性心房颤动的效果较为明确并且优于一般的临床治疗效果,安全性高,值得进一步研究分析和应用. 相似文献
9.
Michael D Taylor Jenny R Roberts Ann F Hubbs Mark J Reasor James M Antonini 《Toxicological sciences》2002,67(2):295-302
Pulmonary fibrosis is a serious lung disorder that in certain cases may be difficult to quantify. It was our objective to evaluate the use of laser scanning confocal microscopy (LSCM) in quantifying fibrosis after exposure to amiodarone (AD) and bleomycin (BLM), two commonly used therapeutic drugs known to cause debilitating lung fibrosis in humans. Male F344 rats were intratracheally dosed with AD (6.25 mg/kg on days 0 and 2), BLM (0.25 and 1.0 mg/kg on day 0), or their respective vehicle controls. The right lung was assayed for hydroxyproline, a biochemical measure of collagen, at day 21 for the BLM groups and day 28 for the AD groups. The left lung was fixed, sectioned into blocks, dehydrated, stained with Lucifer yellow (LY, 0.1 mg/ml), and embedded in Spurr resin. The area of lung tissue stained by LY was quantified by LSCM. A fibrotic response in the AD and BLM groups was confirmed by histopathological assessment and a significant increase (p < 0.05) in total right lung hydroxyproline above control values. The area of connective tissue stained by LY of the two drug-treated groups appeared as bright linear bands in the alveolar septae and was significantly increased (p < 0.05) as measured by image analysis when compared with their respective controls. LSCM, with its advanced image analysis system, is an alternate method to quantify fibrotic lung disease. LSCM could be particularly useful when tissue quantity is limited, such as when tissue has been archived from previous studies, or when analyzing human lung biopsy samples for disease diagnosis, where biochemical analysis is difficult. 相似文献
10.
目的 评价文献中运用心律平与胺碘酮治疗心律失常的疗效.方法 运用计算机检索Pubmed、EMbase、Cochrane图书馆、中国生物医学文献数据库中关于心律平和胺碘酮在治疗心律失常疗效的随机对照试验,将检索时限定为2000年1月~2014年7月.对检索到的论文进行客观质量评价,应用Cochrane协作网提供的Rev Man 5.3软件进行Meta分析.结果 通过药物静脉注射给药,2组心律失常总有效率差异有统计学意义(OR=1.68,95% CI:1.25 ~2.26,P<0.0001);药物口服给药,2组心律失常总有效率差异有统计学意义(OR=1.49,95% CI:1.09 ~ 2.03,P=0.010);2组不良反应发生率比较差异无统计学意义(OR=0.85,95% CI:0.62 ~ 1.16,P>0.05).结论 胺碘酮组治疗心率失常的疗效优于心律平,但对于药物的不良反应率并不增加. 相似文献