全文获取类型
收费全文 | 62074篇 |
免费 | 4695篇 |
国内免费 | 1846篇 |
专业分类
耳鼻咽喉 | 970篇 |
儿科学 | 968篇 |
妇产科学 | 604篇 |
基础医学 | 6741篇 |
口腔科学 | 1540篇 |
临床医学 | 6823篇 |
内科学 | 12499篇 |
皮肤病学 | 895篇 |
神经病学 | 3356篇 |
特种医学 | 1045篇 |
外国民族医学 | 1篇 |
外科学 | 5323篇 |
综合类 | 9446篇 |
现状与发展 | 7篇 |
一般理论 | 2篇 |
预防医学 | 4204篇 |
眼科学 | 834篇 |
药学 | 7232篇 |
44篇 | |
中国医学 | 4654篇 |
肿瘤学 | 1427篇 |
出版年
2024年 | 179篇 |
2023年 | 1182篇 |
2022年 | 2361篇 |
2021年 | 3162篇 |
2020年 | 2614篇 |
2019年 | 2416篇 |
2018年 | 2344篇 |
2017年 | 2410篇 |
2016年 | 2683篇 |
2015年 | 2730篇 |
2014年 | 4983篇 |
2013年 | 5752篇 |
2012年 | 4162篇 |
2011年 | 4478篇 |
2010年 | 3579篇 |
2009年 | 3127篇 |
2008年 | 2867篇 |
2007年 | 2808篇 |
2006年 | 2385篇 |
2005年 | 1927篇 |
2004年 | 1569篇 |
2003年 | 1243篇 |
2002年 | 992篇 |
2001年 | 845篇 |
2000年 | 702篇 |
1999年 | 676篇 |
1998年 | 516篇 |
1997年 | 410篇 |
1996年 | 418篇 |
1995年 | 353篇 |
1994年 | 313篇 |
1993年 | 259篇 |
1992年 | 237篇 |
1991年 | 196篇 |
1990年 | 203篇 |
1989年 | 177篇 |
1988年 | 165篇 |
1987年 | 128篇 |
1986年 | 112篇 |
1985年 | 130篇 |
1984年 | 141篇 |
1983年 | 90篇 |
1982年 | 94篇 |
1981年 | 75篇 |
1980年 | 97篇 |
1979年 | 70篇 |
1978年 | 54篇 |
1977年 | 52篇 |
1976年 | 45篇 |
1974年 | 25篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
良性前列腺增生(BPH)是老年男性常见的泌尿系统疾病,其发病与前列腺慢性炎症之间存在显著相关。感染因子、尿液返流、代谢综合征、衰老过程和自身免疫应答在内的几种刺激,通过相应分子途径引起前列腺免疫细胞的组织定位和组成成分发生广泛改变,从而导致免疫系统失调,之后引发的组织损伤和缓慢愈合,导致了BPH发生和进展。本文通过总结良性前列腺增生与前列腺慢性炎症的相关性的临床研究结果,前列腺免疫细胞在病理生理机制层面与前两者之间的内在联系,以及抗炎药物对BPH-LUTS的干预作用,以其为BPH-LUTS的药物研发提供参考。 相似文献
5.
6.
《Journal of hand therapy》2020,33(1):60-66
Study DesignClinical commentary.Introduction/PurposePain and movement are universally relevant phenomena that influence human experiences in readily observable ways. Improved understanding of pain-movement relationships can guide medical and rehabilitative approaches to recovery and decrease risk of dysfunctional long-term consequences of otherwise normal neuromuscular responses. Therefore, the overall intent of this article is to elucidate the relationships between pain and movement as they relate to clinical decision making.ConclusionsMotor output is highly adaptable, can be influenced by multiple mechanisms at various levels along the nervous system, and may vary between individuals despite similar diagnoses. Therefore, interventions need to be individualized and consider both the types of motor response observed (ie, whether the response is protective or maladaptive), and the patient's acute physical activity tolerance when prescribing exercise/movement. 相似文献
7.
《Journal of endodontics》2020,46(10):1455-1464
IntroductionThe aim of this study was to investigate whether mineral trioxide aggregate (MTA) can be modified with caffeic acid (CA) to form caffeic acid/mineral trioxide aggregate (CAMTA) cement and to evaluate its physicochemical and biological properties as well as its capability in immune suppression and angiogenesis.MethodsMTA was immersed in trishydroxymethyl aminomethane buffer with CA to allow coating onto MTA powders. X-ray diffractometry and tensile stress-strain tests were conducted to assess for physical characteristics of CAMTA and to evaluate for successful modification of MTA. Then, the CAMTA cement was immersed in simulated body fluid to evaluate its hydroxyapatite formation capabilities and Si release profiles. In addition, RAW 264.7 cells and human dental pulp stem cells were used to evaluate CAMTA’s immunosuppressive capabilities and cell responses, respectively. hDPSCs were also used to assess CAMTA’s angiogenic capabilities.ResultsThe X-ray diffractometry results showed that CA can be successfully coated onto MTA without disrupting or losing MTA’s original structural properties, thus allowing us to retain the initial advantages of MTA. CAMTA was shown to have higher mechanical properties compared with MTA and had rougher pitted surfaces, which were hypothesized to lead to enhanced adhesion, proliferation, and secretion of angiogenic- and odontogenic-related proteins. In addition, it was found that CAMTA was able to enhance hydroxyapatite formation and immunosuppressive capabilities compared with MTA.ConclusionsCAMTA cements were found to have improved physicochemical and biological characteristics compared with their counterpart. In addition, CAMTA cements had enhanced odontogenic, angiogenic, and immunosuppressive properties compared with MTA. All of the results of this study proved that CAMTA cements could be a biomaterial for future clinical applications and tissue engineering use. 相似文献
8.
9.
Ahmed M. Abu El-Asrar Ajmal Ahmad Eef Allegaert Mohammad Mairaj Siddiquei Priscilla W. Gikandi Gert De Hertogh 《Ocular immunology and inflammation》2020,28(4):575-588
ABSTRACT
Purpose
To investigate the expression of IL-11 and its receptor IL-11Rα and to quantify density of CD163+ M2 macrophages in proliferative diabetic retinopathy (PDR). 相似文献10.
《Gaceta sanitaria / S.E.S.P.A.S》2015,29(5):390-392
Chronic obstructive pulmonary disease (COPD) is a significant health problem in developed countries. We aimed to estimate the prevalence of COPD in a single Spanish healthcare area. We also aimed to assess if there are any differences in prevalence and spirometry use among primary care services by utilizing already registered information. We designed a cross-sectional study to determine the prevalence of COPD and the performance of spirometries in each primary care service. A total of 8,444 patients were diagnosed with COPD, with a prevalence of 2.6% for individuals older than 39 years. The prevalence increased with age and was much higher in men. Significant heterogeneity was found in the prevalence of COPD and spirometry use among primary care services. COPD was underdiagnosed and there was wide variability in spirometry use in our area. Greater efforts are needed to diagnose COPD in order to improve its clinical outcomes and to refine registries so that they can be used as reliable sources of information 相似文献