Sternal abscess due to Bartonella (Rochalimaea) henselae in a renal transplant patient

 Bartonella henselae, previously called Rochalimaea henselae, is the causative agent of cat scratch disease (CSD) in immunocompetent subjects and bacillary angiomatosis in immunocompromised ones. Bone lesions are common in bacillary angiomatosis, but not in CSD. We present the case of a patient with a renal transplant treated by immunosuppressive therapy who developed a sternal abscess with a histological pattern of CSD. The CT pattern was that of a lytic bone lesion with adjacent fluid collection. The diagnosis was made on the basis of a polymerase chain reaction amplification performed on bone material. Bartonella henselae is a newly described bacteria that causes CSD in a normal host and bacillary angiomatosis in immunocompromised patients. We report a case of an osteolytic lesion of the sternum with adjacent fluid collection related to CSD, which occurred in a patient with a renal transplant.     

The value of abdominal angiography in Turner's syndrome: A case report

In patients with Turner's syndrome, there is a relatively high incidence of gastrointestinal bleeding due to telangiectasias of the intestine. Despite the importance of preoperative diagnosis of the lesion in planning surgical treatment, the related angiographic findings have never been reported. We have studied one patient in whom the diagnosis was established by preoperative angiography. This work was supported in part by USPHS Grant 2 R10-HL15265     

肺毛细血管瘤病二例临床病理观察及文献复习

目的 探讨肺毛细血管瘤病的临床病理特征,提高对其临床及病理改变的认识.方法 对2例肺毛细血管瘤病的临床资料和组织学形态进行回顾性分析,并采用组织化学染色和免疫组织化学染色(EnVision法)研究其形态和免疫表型特点.结果 患者主要临床表现为喘憋,影像学(CT及肺动脉造影)特点为双肺多发结节影,肺动脉增宽,组织学表现为灶状分布的肺问质和肺泡壁毛细血管增生,小动脉肌性化,免疫组织化学染色提示病灶中肥大细胞数量增多,血小板衍生生长因子受体(PDGFR)-β表达上调,Ki-67阳性指数小于1％,p53阴性.结论 肺毛细血管瘤病是一种肺毛细血管增生性疾病,其发病机制可能与肥大细胞数量和PDGFR-β上调有关.病理医师在肺毛细血管瘤病的正确诊断和治疗中起重要作用,应提高对该病的认识.     

Angiomatosis in the Head and Neck—3 Case Reports

Angiomatosis is a diffuse vascular lesion which involves a large segment of the body in a contiguous fashion involving multiple tissues (e.g. subcutis, muscle, bone, adipose tissue etc.) in different planes. Such lesions usually present in the first two decades of life with female predilection and are commonly seen in lower extremities. It clinically mimics hemangioma or vascular malformation and its surgical removal is difficult because of its infiltrative nature and thus has high recurrence rate (90%). Therefore a precise histopathological diagnosis of angiomatosis is important to achieve a curative resection. Histopathologically it consists of proliferating blood vessels of varying caliber, infiltrating into the soft tissues. Proliferating capillaries are seen within or adjacent to major vessels. Few cases are reported in head and neck region. This article highlights three unusual cases of angiomatosis reported as benign lesions, in rare sites such as the malar region (predominantly infiltrating the adipose tissue), within the masseter (predominantly infiltrating the muscle) and in the mandible (infiltrating the bone). Histopathological differential diagnosis is also discussed.     

Pancreatic Angiomatosis: Report of a Case

Recent advances in imaging techniques such as dynamic intravenous contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) have enabled us to detect pancreatic cysts, some of which are potentially malignant. As the histopathological diagnosis cannot be confirmed preoperatively, enlarged pancreatic cysts are usually removed surgically. We report a rare case of pancreatic angiomatosis in a 21-year-old woman who presented with vague abdominal pain, a feeling of fullness, and nausea. Abdominal ultrasonography, contrast-enhanced CT, and MRI showed a huge mass in the right upper abdomen. We performed pylorus-preserving pancreato-duodenectomy, and the histopathological examination of the excised specimen revealed that the tumor was angiomatosis, probably originating from parapancreatic fibro-adipose tissue. She is doing well and has no evidence of recurrence 8 years after the operation. A complete surgical excision should be performed as curative treatment for pancreatic angiomatosis, which is an extremely rare disease when not associated with Von Hippel–Lindau syndrome.     

Osteoblastomatosis of bone. A benign,multifocal osteoblastic lesion,distinct from osteoid osteoma and osteoblastoma,radiologically simulating a vascular tumor

Two adult patients are described with multifocal osteolytic lesions radiologically simulating a vascular tumor. One patient had multiple bones involved. Histologically, the individual lesions had the features of the nidus of osteoid osteoma/osteoblastoma. A review of the English language medical literature yielded only one other reported case with similar features. The process is designated as osteoblastomatosis to indicate its bone-forming character, prominent osteoblast proliferation, and multiplicity. The cases are distinguished from multifocal/multicentric osteoid osteoma and osteoblastoma, and from benign and malignant vascular tumors. Presented at the International Skeletal Society Meeting, (M. Sundaram, Case 7), Toronto, Canada, 1993 (Case 1), and (G.Y. El-Khoury, Case 20) San Francisco, 2003 (Case 2).     

肺硬化性血管瘤10例临床分析

目的 通过探讨肺硬化性血管瘤（ＰＳＨ）的临床、Ｘ线及病理特征,提高对ＰＳＨ的认识。方法 对１０例手术病理证帝的ＰＳＨ患者的临床和肺部Ｘ线表现及病理资料作一回顾性分析。结果 男女之比为１：４,年龄２４￣５７岁,平均４０岁。在６例患者无症状,４例２有症状（咳嗽４例,胸痛３例,咳血丝痰２例,间歇性低热）。Ｘ线胸片多表现为孤立性、圆形或卵圆形、密度均匀、境界清楚、边缘光滑的结节状阴影,肿瘤直径范围为１．５     

The ultrastructure of Sturge-Weber disease

Summary Five infantile and one adult case of Sturge-Weber disease were studied pathologically. The calcification occurring under the leptomeningeal angiomatosis increased with advancing age. Light and electron microscopy of two cases showed the smallest, and therefore possibly the earliest, calcifications occurred in perithelial cells. It is hypothesized the cause of calcification is anoxic injury to endothelial, perithelial and possibly glial mitochondria due to stasis and abnormal vessel permeability in the cerebral vessels composing the Sturge-Weber angioma.     

“Angiodysgenetic necrotizing encephalopathy” and its different manifestations

Summary Various observations of diffuse meningocerebral angiomatoses, which cannot be satisfactorily classified with the common phakomatoses, have been reported. They may occur at any age, with familial accumulation or sporadically. Divry and van Bogaert were the first to draw attention to such conditions in adults, where meningo-cerebral angiomatoses seemed to be combined with sudanophilic leukodystrophy. However, subsequently the latter was considered to be due to hypoxic damage to the white matter. In other observations, the severe damage to the grey matter was more evidently of hypoxic origin. Observations on two newborn individuals, sporadic examples of diffuse meningo-cerebral angiomatosis and with severe necrotic changes in the grey and white matter, are reported and discussed. Published reports on the various age-related forms are summarized and a general designation is suggested, which includes the various observations under a general heading. A parallel will be drawn between the meningo-cerebral angiomatosis and Foix-Alajouanin's disease.Presented at the 27th Annual Meeting of the Japanese Teratology Society, Tokyo, Japan, July 17–18, 1987Dedicated to Professor Hans Jacob, Marburg, on the occasion of his 80th birthday