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Anna‐Mari Hekkala Heikki Vnnen Heikki Swan Lasse Oikarinen Matti Viitasalo Lauri Toivonen 《Annals of noninvasive electrocardiology》2006,11(4):318-326
Background: Accurate measurement of the QT interval is important for diagnosing long QT syndrome (LQTS), and in research on determinants of ventricular repolarization time. We tested automatic analysis of QT intervals from multiple ECG leads on chest. Methods: Eleven healthy volunteers and 10 genotyped LQTS patients were tested at rest and during exercise with a bicycle ergometer twice 1–31 months apart. Electrocardiograms were recorded with the body surface potential mapping system, and 12 precordial channels were selected for analysis. Averaged QT peak and QT end intervals were determined with an automated algorithm, and the difference QT end minus QT peak (Tp‐e) was calculated. Repeatability was assessed by coefficient of variation (CV) between measurements. Results: Within one test at rest the QT end intervals were highly repeatable with CV 0.6%. In repeated tests CV was 4.4% for QT end interval and 3.5% when the QT interval was corrected for heart rate. In exercise test at specified heart rates, mean CV was 3.0% for QT end and 2.9% for QT peak interval. The CV of Tp‐e interval was 10.2% at rest, and 9.3% in exercise test. Reproducibility was comparable between healthy subjects and LQTS patients. Conclusions: The BSPM system with automated analysis produced accurate and highly repeatable QT interval measurements. Reproducibility was adequate also over prolonged time periods both at rest and in exercise stress test. The method can be applied in studying duration of ventricular repolarization time in different physiologic and pharmacologic interventions. 相似文献
3.
The Effects of Na~+/Ca~(2+) exchange (NCX) on the Repolarization of Canine Ventricular Myocyte-Potential Arrhythmogenic Effect of NCX during a Mis-matched Repolarization and Relaxation Xiamen Zhongshan Hospital, Xiamen Medical College, Xiamen University@巩燕$Visiting scholar of cardiac arrhythmia research institute,university hospital of Oklahoma!U.S.A
@王焱
@BELA Szabo$Basic cardiac research laboratory,cardiac arrhythmia research institute,university hospital of Oklahoma!… 相似文献
4.
急性心肌梗塞错误溶栓治疗12例分析 总被引:1,自引:0,他引:1
自1993年12月至1995年8月,对155例急性心肌梗塞(AMI)病人进行溶栓治疗,12例发生误溶(7.7%)。其中早期复极综合征4例,室壁瘤2例,心肌炎1例,心肌病1例,完全性左束支阻滞1例,间歇性左前分支阻滞互例,其它2例。本文分析了误溶病例与AMI的鉴别要点,并提出了减少误溶,提高诊疗水平的措施。 相似文献
5.
Humberto Rodriguez-Reyes Andrs Prez-Riera Brenda Lucia Lpez Maria del Refugio Salinas Luz Ma Mayela Muoz Cesar Ivan Laguna Nikus Kjell 《Annals of noninvasive electrocardiology》2020,25(2)
We present a small child with febrile peaks and syncopal episodes secundary to ventricular tachycardia, in whom it was eventually possible to demostrate the Brugada Syndrome with a special presentation in the ECG; early repolarization pattern in lead I and a aVL and Brugada pattern during fever in V1‐V2. This is, to our knowledge, tha first case with this special ECG presentation in a small child. 相似文献
6.
《Heart rhythm》2022,19(8):1306-1314
7.
Jose Luis Alonso Pablo Martínez Montserrat Vallverdú Iwona Cygankiewicz Maria Vittoria Pitzalis Antoni Bays Genís Juan Cinca Paolo Rizzon Pere Caminal Wojciech Zareba Antoni Bays De Luna 《Annals of noninvasive electrocardiology》2005,10(2):121-128
Background: Patients with impaired left ventricular function have a high risk of developing ventricular arrhythmias and sudden death. Among different markers of risk, the prolongation and regional heterogeneity of repolarization are of increasing interest. However, there are limited data regarding feasibility of analyzing repolarization parameters and their dynamics in 24‐hour Holter ECG recordings. Methods: Dynamic behavior of repolarization parameters was studied with a new automatic algorithm in digital 24‐hour Holter recordings of 60 healthy subjects and 55 patients with idiopathic dilated cardiomyopathy (IDC). Repolarization parameters included the mean value of QT and QTc durations, QT dispersion, and peaks of QT duration and QT dispersion above prespecified thresholds. Results: In comparison to healthy subjects, patients with IDC had lower heart rate variability, longer mean QT and QTc durations, higher content of QTc peaks >500 ms, longer QT dispersion and its standard deviation, and a higher content of peaks >100 ms of QT dispersion (P < 0.01 for all comparisons). These repolarization parameters were significantly higher in IDC patients after adjustment for age, sex, and heart rate variability. The parameters of repolarization dynamics correlated with SDNN in healthy subjects but not in dilated cardiomyopathy patients. Conclusions: The automatic assessment of repolarization parameters in 24‐hour digital ECG recordings is feasible and differentiates dilated cardiomyopathy patients from healthy subjects. Patients with dilated cardiomyopathy have increased QT duration, QT dispersion, and increased variability of QT dispersion reflecting variations in T‐wave morphology, the factors which might predispose them to the development of arrhythmic events. 相似文献
8.
Prognostic value of T‐wave morphology parameters in coronary artery disease in current treatment era
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Background
The prognostic value of T‐wave morphology parameters in coronary artery disease in the current treatment era is not well established.Methods
The Innovation to reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS) study included 1,946 patients with angiographically verified coronary artery disease (CAD). The study patients underwent thorough examinations including 12‐lead digital electrocardiogram (ECG) at baseline.Results
During a follow‐up period of 73 ± 22 months, a total of 201 (10.3%) patients died. Of the study patients, 95 (4.9%) experienced cardiac death (CD) consisting of 44 (2.3%) sudden cardiac deaths (SCD) and 51 (2.6%) nonsudden cardiac deaths (NSCD), and 106 (5.4%) patients experienced noncardiac death (NCD). T‐wave morphology dispersion (TMD), T‐wave area dispersion (TWAD), and total cosine R‐to‐T (TCRT) had a significant association with CD even after adjustment with relevant clinical risk markers in the Cox regression analysis (multivariate HRs: 1.015, 95% CI 1.007–1.023, p = .0003; 0.474, 95% CI 0.305–0.737, p = .0009; 0.598, 95% CI 0.412–0.866, p = .006, respectively). When including these parameters to the clinical risk model for CD, the C‐index increased from 0.810 to 0.823 improving the discrimination significantly (integrated discrimination index [IDI] = 0.0118, 95% CI 0.0028–0.0208, p = .01). These parameters were more closely associated with NSCD (multivariate p‐values from .016 to .001) than with SCD (univariate/multivariate p‐values for TMD .015/.197 and for TCRT .012/.43).Conclusion
T‐wave morphology parameters describing repolarization heterogeneity improve the predictive power of the clinical risk model for CD in patients with CAD in the current treatment era.9.
The prevalence of atrial fibrillation (AF) is forecast to rise to 2–5% of the general population by 2050. Of the two fundamental
treatment strategies for AF management, rhythm control is the approach which is generally preferred for active, symptomatic,
and/or younger patients, whereas rate control is all that is found necessary in the more elderly, sedentary, asymptomatic
individual. In many cases, at neither extreme, there remains a genuine choice of therapy, and for those patients, antiarrhythmic
strategies would be preferred if effective and safe antiarrhythmic medications were available. Many new antiarrhythmic agents
exploiting new mechanisms of action or novel combinations of established antiarrhythmic activity are currently being investigated.
Agents which selectively inhibit ion channels specifically involved in atrial repolarization, so-called atrial repolarization
delaying agents, are widely acknowledged as potentially ideal antiarrhythmic treatments, as they will probably be both effective
and safe, at the very least (free of pro-arrhythmic effects at the ventricular level). Modified analogues of traditional antiarrhythmic
drugs with different combinations of ion channel and receptor blocking effects, novel mechanisms of action, and less complicated
metabolic profiles are also under development. Completely innovative antiarrhythmic agents with new antiarrhythmic mechanisms,
such as stretch receptor antagonism, sodium calcium exchanger blockade, late sodium channel inhibition, and gap junction modulation
are also being explored. In addition, there is increasing evidence in support of the antiarrhythmic action of non-antiarrhythmic
drugs. Treatments with statins, omega-3 fatty acids, angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers,
and aldosterone antagonists are all potentially valuable, over and above any effect related to the treatment of underlying
heart disease.
Professor A. John Camm is a consultant to AstraZeneca, Cardiome, sanofi aventis, and Xention. 相似文献
10.