Osteochondroma of C7 vertebra presenting as compressive myelopathy in a patient with nonhereditary (nonfamilial/sporadic) multiple exostoses

Introduction Osteochondromas are most commonly found in the appendicular skeleton. They occur less frequently in the spine and compression of the spinal cord is very rare. To the best of our knowledge, this is the first report of an osteochondroma arising from C7 vertebra presenting with compressive myelopathy in a patient with nonhereditary multiple exostoses. Our purpose is to report this rare presentation and its successful management, and to highlight the clinico-radiological features of this treatable condition.Materials and methods A 20-year-old male with nonhereditary exostoses presented with gradual onset weakness in bilateral lower limbs, which had rapidly progressed to complete paraplegia over 1 month. The tumor was effectively treated by surgical excision along with spinal decompression. The diagnosis was confirmed by histopathological evidence complemented by clinico-radiological studies.Results There has been a complete functional recovery without any evidence of recurrence at last follow-up at 2 years.Conclusion Compressive myelopathy due to an osteochondroma arising from C7 vertebra in a case with nonhereditary multiple exostoses is being reported for the first time. Both CT and MRI demonstrated the origin, size, extent and relationship of the tumor to the vertebral and neural elements. Complete recovery of functions after surgical decompression was achieved in this case. An osteochondroma of spine must always be considered in all patients with multiple exostoses who have spine pain or develop neural deficit.     

家族性与非家族性大疱性扁平苔藓临床分析

目的　比较家族性与非家族性大疱性扁平苔藓 (BLP)临床特点的异同。方法　对 3 6例家族性BLP和 2 1例非家族性BLP的临床资料进行对比分析。结果　家族性与非家族性BLP在初发年龄、病程及皮损累及范围等方面均存在明显差异 (P均 <0 .0 1)。结论　与非家族性BLP相比 ,家族性BLP患者发病年龄更小、病程更长、范围更广、更易累及甲。遗传因素在BLP的发病中可能起重要作用。     

Contexts of Collaboration in Caregiving: Infant Interactions with Israeli Kibbutz Mothers and Caregivers

This report directly compares caregiving activities of mothers and nonfamilial care-givers in the context of the Israeli kibbutz, where responsibilities for chiidrearing are typically shared according to formalized kibbutz social norms. For comparison, the study also included full-time homemaker mothers from typical, urban nuclear families in Israel. The frequency and sequence of common caregiving activities showed similarities and differences among mothers and caregivers, as did patterns of associations among mother and caregiver behaviors and patterns of interactions between mothers and infants as well as between caregivers and infants. Infants themselves differed in exploration and vocalization with different caregivers. Caregiving activities, interactions, and developmental processes provided by kibbutz mothers and professional nonfamilial caregivers are discussed in terms of a “division of caregiving responsibilities,” and they are compared with caregiving provided by homemaker mothers.     

Recurrence of nonfamilial cardiac myxoma in the left ventricle: A case report

A left atrial myxoma was found and removed in a 47‐year‐old woman admitted for acute ischemic cerebrovascular disease, without family history of cardiac tumor. Follow‐up echocardiography, 15 months later, demonstrated a new myxoma in the left ventricle. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 42 :576–577, 2014     

Glomerular morphometry II: familial and nonfamilial haematuria

Differential glomerular cell counts and measurements of glomerular diameter were made in 13 children with Alport's syndrome (AS), four with benign familial haematuria (BFH) and 15 with nonfamilial haematuria (NFH). Mesangial cellularity was increased in the six cases of NFH with diffuse mesangial deposits of IgA (IgA+). In AS, IgA+ and -NFH, epithelial cellularity decreased with age while glomerular diameter increased. In AS mesangial and endothelial cellularity also decreased with age. These findings support the view that AS, IgA + and -NFH are three distinct entities. BFH, although similar in several respects to IgA–NFH, should nevertheless be retained as a separate category by virtue of its familial incidence of haematuria.     

Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India

Purpose:This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients.Methods:One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR.Results:Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome.Conclusion:Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB.