全文获取类型
收费全文 | 766篇 |
免费 | 73篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 40篇 |
口腔科学 | 14篇 |
临床医学 | 33篇 |
内科学 | 20篇 |
皮肤病学 | 579篇 |
神经病学 | 1篇 |
特种医学 | 2篇 |
外国民族医学 | 1篇 |
外科学 | 9篇 |
综合类 | 33篇 |
预防医学 | 3篇 |
眼科学 | 83篇 |
药学 | 16篇 |
中国医学 | 3篇 |
肿瘤学 | 4篇 |
出版年
2024年 | 1篇 |
2023年 | 19篇 |
2022年 | 35篇 |
2021年 | 29篇 |
2020年 | 44篇 |
2019年 | 42篇 |
2018年 | 36篇 |
2017年 | 26篇 |
2016年 | 39篇 |
2015年 | 25篇 |
2014年 | 43篇 |
2013年 | 31篇 |
2012年 | 28篇 |
2011年 | 41篇 |
2010年 | 26篇 |
2009年 | 31篇 |
2008年 | 28篇 |
2007年 | 26篇 |
2006年 | 21篇 |
2005年 | 30篇 |
2004年 | 21篇 |
2003年 | 26篇 |
2002年 | 22篇 |
2001年 | 25篇 |
2000年 | 23篇 |
1999年 | 17篇 |
1998年 | 12篇 |
1997年 | 11篇 |
1996年 | 16篇 |
1995年 | 11篇 |
1994年 | 13篇 |
1993年 | 6篇 |
1992年 | 8篇 |
1991年 | 2篇 |
1990年 | 7篇 |
1989年 | 3篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1977年 | 1篇 |
排序方式: 共有848条查询结果,搜索用时 687 毫秒
1.
Angela Mauro Salvatore Mauro Roberto Rega Luigi Martemucci Rita Sottile 《Pediatric dermatology》2019,36(1):e34-e36
Henoch‐Schonlein purpura (HSP) is the most common systemic vasculitis in childhood. There is no consensus about the management for isolated cutaneous manifestations in HSP. We describe a case of HSP presenting with severe skin lesions that did not respond to standard therapy with corticosteroids. The 11‐year‐old child was treated with intravenous immunoglobulins, which induced rapid and persistent resolution of symptomatology. 相似文献
2.
A Kacalak-Rzepka† E Zaluga† R Maleszka† A Królicki† A Klimowicz‡ 《Journal of the European Academy of Dermatology and Venereology》2004,18(4):490-494
We report the case of a 44-year-old male with a 10-year history of manifestations of the rare form of bullous systemic lupus erythematosus (SLE) with coexisting antiphospholipid syndrome (APS) that remained undiagnosed until thrombotic-embolic episodes appeared and high titres of anticardiolipin (ACL) antibodies were detected. The patient fulfilled the criteria for SLE and the atypical cutaneous manifestations together with histopathological changes and a favourable response to sulphones were the grounds for the diagnosis of the bullous variety of SLE. Treatment with prednisolone, acenocoumarol and dapsone resulted in marked clinical improvement, reduction in antinuclear antibodies (ANAs) and normalization of ACL antibody titres. 相似文献
3.
报告7例疱疹样脓疱病,并分析指出本病发生与妊娠、低血钙无明显关系,同意该病区别于典型的泛发性脓疱性银屑病。雷公藤单用或并用皮质激素有较好效果,亦应重视雷公藤的副作用。 相似文献
4.
Yasuhiko Tamada Kikuka Yokochi Yoshimi Oshitani Yukiko Nitta Toshihiko Ikeya Kazuo Hara Katsushi Owaribe 《The Journal of dermatology》1995,22(3):201-204
We report a 73-year-old woman with typical clinical, histological and immunofluorescence features of pemphigoid nodularis. Direct immunofluorescence studies of prurigo nodularis-like lesions and peribullous skin showed the linear deposition of IgG and C3 at the basement membrane zone. Circulating IgG against the basement membrane was also detected by indirect immunofluorescence. The serum from the patient was shown to contain the autoantibody against 230 kDa hemidesmosomal antigen associated with bullous pemphigoid antigen. 相似文献
5.
Marcelo H. Grunwald Boaz Amichai Hani Giryes Sima Halevy 《Journal of the European Academy of Dermatology and Venereology》1997,9(2):166-168
We report a case of erythrodermic type of bullous pemphigoid which is a rare variant of bullous pemphigoid. Our patient had a peculiar clinical presentation with bullae, erosions and extensive erythrodermic areas, and distinct direct immunofluorescent findings which included linear IgG and C3 deposits in the basement membrane and also IgG in the intercellular spaces. Very high levels of serum IgE were also detected in our patient. 相似文献
6.
7.
Mortality in bullous pemphigoid: A systematic review and meta‐analysis of standardized mortality ratios
下载免费PDF全文
![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Khalaf Kridin Naama Schwartz Arnon D. Cohen Shira Zelber‐Sagi 《The Journal of dermatology》2018,45(9):1094-1100
There are inconsistent data on mortality rates in patients with bullous pemphigoid (BP). Trends in mortality in BP throughout the years are yet to be established. The aim of the present study was to study the mortality in BP patients relative to the general population and to estimate trends in standardized mortality over the past 30 years. We performed a systematic review and meta‐analysis of observational studies in Medline, Embase and Scopus (1823–2017). Reference lists of included studies were also searched for eligible studies. Quality of evidence was assessed using the Newcastle–Ottawa Scale (NOS). A meta‐analysis was performed using random‐effects models to estimate pooled standardized mortality ratios (SMR) with 95% confidence intervals (CI). Meta‐regression models were used to investigate the secular trends in SMR. Ten studies were included covering the period 1960–2015 (1736 patients, 746 deaths). Pooled all‐cause SMR was 3.6 (95% CI, 2.6–5.0). There was no trend in all‐cause SMR across the last three decades (regression coefficient 0.02 [change in logSMR/year]; 95% CI, 0.04–0.08; P = 0.545). In conclusion, there is a 3.6‐fold increased mortality among patients with BP as compared with the age‐matched general population. The excess mortality in BP has not changed significantly over the past 30 years. 相似文献
8.
Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10‐13 years), middle (14‐17), and late (18‐21). This review aimed to identify BP cases in adolescence and demonstrate their clinical features and course. Our literature search was performed in Medline with the terms “bullous pemphigoid in childhood and adolescence,” “childhood bullous pemphigoid,” “juvenile bullous pemphigoid,” and “autoimmune blistering and autoimmune bullous diseases in childhood.” The data extraction for late adolescence was limited by the fact that this age group is included in adult BP registries. We identified nine cases in early adolescence. Mucosa were affected in 5 of 9 cases. Treatment consisted of systemic prednisone (8/9), in combination with dapsone (2/9), azathioprine (2/9), or erythromycin/nicotinamide (1/9). Relapses were reported in 3 of 9 cases. We identified five cases occuring in middle adolescence. Mucosa were not affected. Treatment consisted of systemic prednisone (5/5), in combination with dapsone (3/5), azathioprine (2/5), doxycycline/nicotinamide (1/5), or mycophenolate mofetil (1/5). Relapses were reported in two of five cases. No case of BP in the late adolescence was included in the results, as only one case met the search criteria, and overlapped with pemphigus vulgaris. With only 14 cases found in our review, BP in adolescence appears even rarer than in earlier childhood. Despite its low prevalence, BP should be included in the differential diagnosis of autoimmune blistering diseases in adolescents. 相似文献
9.
10.
M. Michael Cohen Jr. 《Clinical genetics》2014,85(2):111-119
Proteus syndrome is caused by an activating AKT1 mutation (c.49G>A, p.Glu17Lys). Many variable features are possible in this mosaic disorder, including: (i) disproportionate, asymmetric, and distorting overgrowth; (ii) bone abnormalities different from those observed in other disorders; (iii) a characteristic cerebriform connective tissue nevus made up of highly collagenized connective tissue; (iv) epidermal nevi in early life, consisting of acanthosis and hyperkeratosis; (v) vascular malformations of the capillary, venous, or lymphatic types; (vi) dysregulated adipose tissue including lipomas, lipohypoplasia, fatty overgrowth, and localized fat deposits; (vii) other unusual features, including bullous lung alterations; specific neoplasms; a facial phenotype associated with intellectual disability and/or seizures, and/or brain malformations; and (viii) deep vein thrombosis, resulting in premature death. Concluding remarks address diagnostic criteria, natural history, management, psychosocial issues, and differential diagnosis. 相似文献