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R. Karlsson B. Agrell S. Dreborg T. Foucard N.-I. M. Kjellman A. Koivikko R. Einarsson 《Allergy》1986,41(2):141-150
This double-blind immunotherapy trial in children, using a purified and standardized Cladosporium herbarum allergen preparation, has shown that children with mould asthma and/or rhinoconjunctivitis, responded to immunotherapy with a decrease in specific IgE and a significant increase in specific IgG. There was a marked increase in the ratio specific IgG/specific IgE as a result of active treatment. IgE-CRIE radiostaining patterns showed no pronounced changes after 10 months' active treatment and no "new sensitivities" could be detected in the studied patients. IgG-CRIE radiostaining, primarily directed towards the important allergens, was significantly increased in the active group and particularly towards Ag-12 (partially identical to a previously described major allergen in Cladosporium herbarum, Ag-54). Children treated with histamine placebo showed no change in antibody patterns during 10 months of treatment. 相似文献
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Don Vicendese Shyamali C. Dharmage Mimi L. K. Tang Andriy Olenko Katrina J. Allen Michael J. Abramson 《The Journal of asthma》2015,52(7):727-731
Objective: Indoor environment factors have been associated with risk of asthma exacerbations in children but little is known about their role on asthma hospital readmissions. As children in Western societies continually spend more time indoors, understanding the influence of these factors on asthma exacerbation is important. We examined the role of indoor environmental and lifestyle characteristics on child asthma readmissions. Methods: A hospital-based case–control study recruited 22 children readmitted for asthma and 22 controls not readmitted for asthma. Logistic regression models were used to examine the association between aeroallergens and fungi in the bedroom and indoor lifestyle characteristics factors for asthma readmissions. To determine the best possible set of predictors among a large set of risk factors, we used random forests (RF) techniques. Results: Higher levels of airborne Cladosporium and yeast in the child’s bedroom increased risk of readmission (OR?=?1.68, 95% CI 1.04–2.72 and OR?=?1.52, 95% CI 0.99–2.34, respectively). Carpeted floors in the bedroom and synthetic doonas were also associated with increase in asthma readmissions (OR?=?4.07, 95% CI 1.03–16.06 and OR?=?14.6, 95% CI 1.26–169.4, respectively). In the home, frequent vacuuming using bagged cleaners increased risk of asthma readmission OR?=?15.7 (95% CI 2.82–87.2). Conclusions: Factors in the child’s bedroom play an important role in increasing the risk of asthma hospital readmissions. These findings have major clinical implications as the identified potential risk factors may be modifiable. Further epidemiological studies with larger samples are necessary to evaluate these associations further. 相似文献
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S. Dreborg B. Agrell T. Foucard N.-I. M. Kjellman A. Koivikko S. Nillson 《Allergy》1986,41(2):131-140
A double-blind histamine placebo controlled immunotherapy trial was performed to investigate the clinical effect of a purified and standardized Cladosporium herbarum allergen preparation. Thirty children with a clinical history suggesting mould-induced asthma and/or rhinoconjunctivitis were included. The diagnosis was confirmed by positive skin prick test and Phadebas RAST as well as positive bronchial and/or conjunctival provocation test to Cladosporium herbarum. Immunotherapy was given for 10 months in a double-blind manner to randomized groups with either Pharmalgen/Cladosporium herbarum preparation or histamine placebo. Allergic side effects to injections were common, especially during the peak of the mould season (July-September in Scandinavia). In the active group, 13/16 patients experienced general reactions during the first 10 months of treatment. After 6 months of treatment, eye, nose and bronchial symptom scores and peak expiratory flow rates were similar for the groups, maybe because most of the children were also sensitive to many other allergens, including Alternaria alternata. However, medication scores were significantly lower in the treated group (P less than 0.01). Bronchial (P less than 0.01) and conjunctival sensitivity (P = 0.01) were significantly reduced in the Cladosporium-treated group but not in the placebo group after 10 months of treatment. This is the first double-blind clinical trial showing the clinical efficacy of immunotherapy in children with mould-induced asthma. 相似文献
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Zusammenfassung: Bei der Chromomykose handelt es sich um eine selten vorkommende, chronische, fast ausschlieBlich die Haut betreffende Infektion, hervorgerufen durch bestimmte dunkelpigmentierte Pilzarten.
Klinik, Diagnostik und Therapie der Chromomykose werden am Beispiel eines aus Madagaskar stammenden Patienten besprochen.
Kulturell konnte bei ihm Cladosporium carrionii Trejos 1954 diagnostiziert werden.
Der Pilz zeigte in vitro gute Empfmdlichkeit gegenüber Ketoconazol und wenig bzw. keine Empfmdlichkeit gegen 5-Flucytosin und Amphotericin B.
Ketoconazolbehandlung die noch fortgesetzt wird, führte bei einer Dosis von 400 mg täglich in 4 Monaten ohne Nebenwirkungen zu einer wesentlichen Besserung des Hautbefundes.
Summary: Chromomycosis is an infrequently observed, chronic infection, almost exclusively involving the skin. It is caused by certain dark-coloured moulds.
Clinical features of chromomycosis are presented in a patient from Madagaskar with implications on diagnosis and therapy. It was possible to isolate Cladosporium carrionii Trejos 1954. In vitro this fungus was sensitive to Ketoconazole, whereas there was little or no sensitivity to 5-Flucytosine and Amphotericin B.
Treatment with Ketoconazole (400 mg daily) already showed a marked regression of the skin disease in 4 months without any adverse effects of the drug. 相似文献
Klinik, Diagnostik und Therapie der Chromomykose werden am Beispiel eines aus Madagaskar stammenden Patienten besprochen.
Kulturell konnte bei ihm Cladosporium carrionii Trejos 1954 diagnostiziert werden.
Der Pilz zeigte in vitro gute Empfmdlichkeit gegenüber Ketoconazol und wenig bzw. keine Empfmdlichkeit gegen 5-Flucytosin und Amphotericin B.
Ketoconazolbehandlung die noch fortgesetzt wird, führte bei einer Dosis von 400 mg täglich in 4 Monaten ohne Nebenwirkungen zu einer wesentlichen Besserung des Hautbefundes.
Summary: Chromomycosis is an infrequently observed, chronic infection, almost exclusively involving the skin. It is caused by certain dark-coloured moulds.
Clinical features of chromomycosis are presented in a patient from Madagaskar with implications on diagnosis and therapy. It was possible to isolate Cladosporium carrionii Trejos 1954. In vitro this fungus was sensitive to Ketoconazole, whereas there was little or no sensitivity to 5-Flucytosine and Amphotericin B.
Treatment with Ketoconazole (400 mg daily) already showed a marked regression of the skin disease in 4 months without any adverse effects of the drug. 相似文献
8.
The interrelation of in vitro IgE-mediated parameters, i.e. serum-specific IgE (RAST), basophil cell-bound specific IgE, and histamine release from basophil leucocytes was investigated in a 1-year placebo-controlled, double-blind Cladosporium immunotherapy study involving 22 adult asthmatics. The intense and early burst (within 6 weeks of immunotherapy) of serum-specific IgE did not result in a corresponding increased binding of specific IgE molecules to basophils. Cell-bound IgE increased in the Cladosporium season in both groups at the same time as serum levels of specific IgE declined in the Cladosporium group. In the placebo group histamine release from circulating basophils paralleled changes in basophil-bound IgE. In Cladosporium-treated patients, histamine release cell sensitivity after a lag phase (during immunotherapy dose-increase) declined two log steps, i.e. the cells became less responding in spite of a significant increase in cell-bound IgE. To further evaluate the sensitizing capacity of circulating specific IgE, passive sensitization studies were performed using basophils from a single donor. Although sera taken at the maximal IgE-response showed an enhanced capacity of passive sensitization, the ratio between RAST and passive sensitization capacity increased significantly in Cladosporium-treated patients, implying a less than expected sensitization capacity of immunotherapy-induced specific IgE. The lack of active binding of IgE to basophils might be explained by a reduced Fc-affinity of immunotherapy-induced IgE in contrast to the Cladosporium-seasonally induced IgE. Regarding the decrease in histamine release in Cladosporium-treated patients in spite of an increased amount of cell-bound specific IgE, immunotherapy may initiate a decrease in mediator releasibility which is not caused by a reduction in the number of Fc-receptors but rather some yet unknown subcellular mechanisms regulating the histamine release. The described changes in IgE-mediated parameters do not seem to be caused by interference with either specific IgG1 or IgG4. Changes in histamine release in the Cladosporium season were the only IgE-mediated parameter significantly related to the graded clinical efficacy of immunotherapy. 相似文献
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Zhen Fan Zhang-Hua Sun Hong-Xin Liu Yu-Chan Chen Hao-Hua Li 《Journal of Asian natural products research》2016,18(11):1024-1029
A pair of new azaphilone epimers, perangustols A-B (1–2), and two new natural products (3–4), together with two known metabolites (5–6) were isolated from the culture of the marine sediment-derived fungus Cladosporium perangustum FS62. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The isolated compounds (1–6) were evaluated for their cytotoxic activities against the SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. Nonetheless, no significant activity was observed. 相似文献
10.
枝孢样枝孢所致皮肤暗色丝孢霉病一例 总被引:3,自引:0,他引:3
目的报道国内首见枝孢样枝孢所致的皮肤暗色丝孢霉病1例。方法患者女,49岁,右臀部肿块近2年,瘢痕纤维化的同时有新的肿块形成,并形成囊肿坏死、窦道形成,皮肤表面破损,大量渗液,触痛明显,皮损边界基本清晰。从患者皮损取材、涂片及培养。并经致病性研究重现组织病理学特征。结果培养菌落呈绒状,橄榄绿到橄榄棕色,反面为橄榄黑色。显微镜下,分生孢子梗末端和外侧可产生枝状分生孢子链,分生孢子椭圆形或柠檬形。壁光滑。根据直接镜检和培养的菌落形态及显微镜下分生孢子的大小、形态、排列及培养温度试验等特征,鉴定为枝孢样枝孢。结论该病例为国内首报的由枝孢样枝孢引起的暗色丝孢霉病。 相似文献