Study on the Shear Modulus Based Equivalent Homogenization Methods of Multi-Layer BCC Lattice Sandwich

In this paper, the shear modulus based equivalent homogenization methods of multi-layer BCC (body-centered cubic) lattice sandwich structures have been studied using analytical, experimental, and finite element methods. In the analytical approach, the multiple strut-deformation patterns were introduced in the derivations of the shear modulus based on Euler–Bernoulli beam theory and Timoshenko beam theory according to different boundary conditions. The analytical shear modulus of three types of rectangle shaped sandwich BCC lattice structures was derived. Finite element models of the BCC lattice structures by ANSYS were conducted to estimate the analytical solutions. Butterfly style sandwich BCC lattice structures were printed by SLM technology using 304 stainless steel (06Cr19Ni10), and corresponding shear experiments using modified Arcan Rig experimental devices were conducted to validate the analytical and numerical calculations. Good agreements were observed among the analytical, numerical, and experimental results.     

Laser-induced fluorescence spectroscopy for in vivo diagnosis of non-melanoma skin cancers

BACKGROUND AND OBJECTIVES: Laser-induced fluorescence spectroscopy is a non-invasive technique previously used for detection of cancer in a variety of organ systems. The objective of this study was to determine whether in vivo laser-induced fluorescence spectroscopy alone at the visible excitation wavelength of 410 nm could be used to detect non-melanoma skin cancers. STUDY DESIGN/MATERIALS AND METHODS: The system consisted of a nitrogen/dye laser tuned at 410 nm, an optical multichannel analyzer, and a fiber optic probe for excitation of tissue and collection of fluorescence emission. Two hundred and seventy nine measurements were performed from normal and abnormal tissues in 49 patients. Patients were classified as having either skin types I, II, or III. Biopsy of the abnormal tissues were then performed. Each measurement was assigned as either normal, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), pre-cancerous, or benign. Total emission photon count was used as the discriminating index. A threshold value was calculated to separate normal tissue indices from indices of cancer tissues. The classification accuracy of each data point was determined using the threshold value. RESULTS: Cancers were classified 93, 89, and 78% correctly in patients with skin types I, II, and III, respectively. Normal tissues were classified 93, 88, and 50% correctly in patients with skin types I, II, and III, respectively. Using the same threshold, pre-cancerous spectra were classified 78 and 100% correctly in skin types I and III, respectively. Benign lesions were classified 100, 46, and 27% correctly in patient with skin types I, II, and III, respectively. CONCLUSIONS: In vivo laser induced fluorescence spectroscopy at 410 nm excitation and using the intensity of emission signal is effective for detection of BCC, SCC, and actinic keratosis, specially in patients with light colored skin.     

皮肤癌诊治探讨

目的探讨皮肤癌的临床诊断及有效治疗方法。方法对根据临床表现及病理确诊的58例基底细胞癌及鳞状细胞癌患者进行手术治疗。结果瘤体切除后，7例直接切除拉拢缝合者均达Ⅰ期愈合，23例行局部皮瓣转移修复者，皮瓣成活良好且外观满意。28例植皮修复者2例表皮营养不良，3例部分植皮坏死，均经换药愈合。随访42例，38例未见复发及转移。结论皮肤癌手术治疗效果满意。     

Immunohistochemical FHIT expression still exists in early lesions of basal cell carcinoma

In this study, we evaluated the expression of Fragile Histidine Triad (FHIT) in basal cell carcinoma (BCC). The FHIT locus was found to be altered in numerous types of cancer 6, 7, 18, 20, 22, 25 and 26. However, we found only one study dealing with FHIT expression in BCC [11].     

The effect of enteral tube feeding in cystic fibrosis: A registry based study

Background

Long-term effect of enteral tube feeding (ETF) in cystic fibrosis (CF) remains equivocal.