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The treatment of elderly patients requires daily careful management and monitoring because of their polypathology, polymedication and of their greater sensitivity to the toxic effects of drugs.On March 9, 2004 the French Agency of Medical Safety of the Products of Health issued a press release relating to the safety of the use of antipsychotics for patients suffering from dementia.This article presents a study undertaken in a psychogeriatric unit of a Department of General Psychiatry, in the University Hospital of Clermont-Ferrand. The purpose of this study was to highlight the evolution of antipsychotic prescriptions among patients suffering from dementia before and after the press release publication.In a more general way, an analysis of the prescriptions of antipsychotics in elderly patients was also carried out.This study led to the elaboration, concurrently with the department of pharmacy, of a form for the antipsychotic prescriptions of elderly patients suffering or not from dementia.  相似文献   
10.

Objective

To investigate the relation between donor characteristics and TRALI incidence.

Background

Transfusion-related acute lung injury (TRALI) is a potentially fatal complication of transfusion. In pre-clinical studies and several clinical studies, TRALI has been related to loss of product quality during red blood cell (RBC) storage, called the “storage lesion”. Donor characteristics, as for example age, genetics and life style choices influence this “storage lesion”. We hypothesized that donor sex, age and blood type is related to TRALI incidence.

Methods/materials

We performed a secondary analysis of two cohort studies, designed to identify TRALI risk factors by matching TRALI patients to transfused controls. We obtained donor sex, age and blood type from the Dutch Blood Bank Sanquin and investigated TRALI incidence in patients who were exposed to a certain donor characteristic. We used Kruskal-Wallis testing to compare the number of transfused products and Chi2 testing to compare proportions of TRALI patients and transfused control.

Results

After implementation of the male-donor only plasma strategy, patients received more transfusion products from male donors. However, we did not detect a relation between TRALI incidence and donor sex. Both TRALI patients and transfused controls received mainly products from donors over 41 years old, but donor age did not influence TRALI risk. Donor blood type, the transfusion of blood type-compatible and blood type-matched products also had no influence on TRALI incidence.

Conclusion

We conclude that in two cohorts of TRALI patients, donor age, donor sex and donor blood type are unrelated to TRALI.  相似文献   
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