全文获取类型
收费全文 | 120845篇 |
免费 | 9017篇 |
国内免费 | 4801篇 |
专业分类
耳鼻咽喉 | 612篇 |
儿科学 | 2410篇 |
妇产科学 | 1620篇 |
基础医学 | 17766篇 |
口腔科学 | 2208篇 |
临床医学 | 9561篇 |
内科学 | 21194篇 |
皮肤病学 | 1558篇 |
神经病学 | 10760篇 |
特种医学 | 2132篇 |
外国民族医学 | 27篇 |
外科学 | 8961篇 |
综合类 | 18612篇 |
现状与发展 | 25篇 |
一般理论 | 1篇 |
预防医学 | 6829篇 |
眼科学 | 1838篇 |
药学 | 15532篇 |
28篇 | |
中国医学 | 3697篇 |
肿瘤学 | 9292篇 |
出版年
2024年 | 262篇 |
2023年 | 1538篇 |
2022年 | 4004篇 |
2021年 | 5071篇 |
2020年 | 3945篇 |
2019年 | 3949篇 |
2018年 | 4018篇 |
2017年 | 3784篇 |
2016年 | 3953篇 |
2015年 | 4453篇 |
2014年 | 7296篇 |
2013年 | 8173篇 |
2012年 | 7319篇 |
2011年 | 8097篇 |
2010年 | 6567篇 |
2009年 | 6150篇 |
2008年 | 6302篇 |
2007年 | 6190篇 |
2006年 | 5451篇 |
2005年 | 5009篇 |
2004年 | 4183篇 |
2003年 | 3748篇 |
2002年 | 2816篇 |
2001年 | 2449篇 |
2000年 | 2107篇 |
1999年 | 1841篇 |
1998年 | 1825篇 |
1997年 | 1651篇 |
1996年 | 1360篇 |
1995年 | 1133篇 |
1994年 | 1063篇 |
1993年 | 905篇 |
1992年 | 810篇 |
1991年 | 750篇 |
1990年 | 625篇 |
1989年 | 562篇 |
1988年 | 530篇 |
1987年 | 496篇 |
1986年 | 470篇 |
1985年 | 669篇 |
1984年 | 588篇 |
1983年 | 388篇 |
1982年 | 479篇 |
1981年 | 387篇 |
1980年 | 329篇 |
1979年 | 235篇 |
1978年 | 183篇 |
1977年 | 152篇 |
1976年 | 115篇 |
1975年 | 93篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
周蕾 《国际妇产科学杂志》2015,42(1):91-95
宫颈癌对妇女健康构成严重威胁,人乳头瘤病毒感染与宫颈病变及宫颈癌的发生密切相关。关于宫颈癌发生发展的机制仍在研究中。近年研究发现一种多功能核蛋白,即死亡结构域相关蛋白(death domain associated protein,Daxx),其与细胞内蛋白或病毒蛋白相互作用,参与调节细胞凋亡、转录调控、抗病毒等细胞活动,在不同途径中发挥不同的生理或病理作用。通过对Daxx功能及其作用机制的研究有助于进一步阐明宫颈癌发生发展的机制,有助于发现新的预防和治疗方法。综述Daxx的一般特性和研究现况及其在宫颈病变的研究进展。 相似文献
3.
4.
Akira Mogi Toshiki Yajima Kenji Tomizawa Ryoichi Onozato Shigebumi Tanaka Hiroyuki Kuwano 《Annals of thoracic and cardiovascular surgery》2015,21(5):435-439
Purpose: Small pulmonary lesions that include ground-glass attenuation have been increasingly discovered because of progressive imaging diagnostic technologies. Despite the detection of such small lesions, sometimes it is quite difficult to localize them because of their size or considerable depth from the visceral pleura. In the present study, we examined the usefulness of computed tomography-guided lipiodol marking for thoracoscopic resection of impalpable pulmonary nodules.Methods: Fifty-six patients with an undiagnosed peripheral lesion(s) of the lung who had undergone preoperative computed tomography-guided lipiodol marking followed by video-assisted thoracoscopic surgery were studied.Results: All of the nodules were successfully marked by computed tomography-guided lipiodol marking, and all except for one case were localized by means of intraoperative fluoroscopy as clear spots. With regard to complications, pneumothorax occurred in 21 patients (37.5%), and only one patient required transient drainage. Although hemorrhaging in the lung parenchyma and hemosputum occurred in nine patients (16.1%) and one patient (1.8%), respectively, no patients were in serious condition. No intra- or postoperative mortality or morbidity was observed.Conclusion: Preoperative computed tomography-guided lipiodol marking of small or impalpable pulmonary nodules is a safe and useful procedure for thoracoscopic resection of the lung. 相似文献
5.
《Mayo Clinic proceedings. Mayo Clinic》2019,94(7):1321-1329
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been associated with the emergence of a new subset of autoimmune-like toxicities, known as immune-related adverse events. These toxicities differ depending on the agent, malignancy, and individual susceptibilities. Although the skin and colon are most commonly involved, any organ may be affected, including the liver, lungs, kidneys, and heart. Most of these toxicities are diagnosed by excluding other secondary infectious or inflammatory causes. Corticosteroids are commonly used for treatment of moderate and severe immune-related adverse events, although additional immunosuppressive therapy may occasionally be required. The occurrence of immune-related toxicities may require discontinuation of immunotherapy, depending on the specific toxicity and its severity. In this article, we provide a focused review to familiarize practicing clinicians with this important topic given that the use of immune checkpoint inhibitors continues to increase. 相似文献
6.
《Gaceta sanitaria / S.E.S.P.A.S》2015,29(5):390-392
Chronic obstructive pulmonary disease (COPD) is a significant health problem in developed countries. We aimed to estimate the prevalence of COPD in a single Spanish healthcare area. We also aimed to assess if there are any differences in prevalence and spirometry use among primary care services by utilizing already registered information. We designed a cross-sectional study to determine the prevalence of COPD and the performance of spirometries in each primary care service. A total of 8,444 patients were diagnosed with COPD, with a prevalence of 2.6% for individuals older than 39 years. The prevalence increased with age and was much higher in men. Significant heterogeneity was found in the prevalence of COPD and spirometry use among primary care services. COPD was underdiagnosed and there was wide variability in spirometry use in our area. Greater efforts are needed to diagnose COPD in order to improve its clinical outcomes and to refine registries so that they can be used as reliable sources of information 相似文献
7.
8.
9.
《Vaccine》2021,39(26):3498-3508
Adenovirus infections are a major cause of epidemic keratoconjunctivitis (EKC), which can lead to corneal subepithelial infiltrates and multifocal corneal opacity. In the current study, we investigated the use of an E1/E3-deleted adenovirus serotype 5 (Ad5) vector as a vaccine administered intramuscularly (IM) or intranasally (IN) against subsequent challenges with a luciferase-expressing Ad5 (Ad5-Luci) vector via eyedrop. We evaluated the adaptive immune response to Ad5 vector vaccination and confirmed a robust polyfunctional CD8 T cell response in splenic cells. Neutralizing Ad5 antibodies were also measured in the sera of vaccinated mice as well as Ad5 antibody in the eye wash solutions. Upon challenge with Ad5-Luci vector 8 weeks post the primary immunization, transduction was significantly reduced by > 70% in the vaccinated mice, which was slightly better in IM- vs. that in IN-vaccinated animals. Resistance to subsequent challenge was observed 10 months post primary IM vaccination, with sustained reduction up to 60% in the Ad5-Luci vector transduction. Passive immunization of naive mice with antisera from IM to vaccinated mice subsequently challenged with the Ad5-Luci vector resulted in approximately 40% loss in transduction efficiency. Furthermore, the mice that received IM immunization with or without CD8 T cell depletion showed > 40% and 70% reductions, respectively, in Ad8 genomic copies after Ad8 topical challenge. We conclude that Ad-vector vaccination successfully induced an adaptive immune response that prevented subsequent Ad transduction in the cornea and conjunctiva-associated tissues in a mouse model of adenovirus keratoconjunctivitis, and that both cellular and humoral immunity play an important role in preventing Ad transduction. 相似文献
10.
Jae Eun Choi Tyler Werbel Zhenping Wang Chia Chi Wu Tony L. Yaksh Anna Di Nardo 《Journal of dermatological science》2019,93(1):58-64