Outcomes of Donation After Circulatory Death Heart Transplantation in Australia

Background

Transplantation of hearts retrieved from donation after circulatory death (DCD) donors is an evolving clinical practice.

急性白血病相关基因WIT-1的克隆及临床意义

目的：克隆白血病相关基因及白血病相关基因甲基化的临床意义。方法：应用新的分子克隆技术ＲＬＧＳ及ＳｏｕｔｈｅｒｎＢｌｏｔ技术自急性髓细胞白血病（ＡＭＬ）骨髓标本中克隆白血病相关基因对该基因的甲基化进行检测。结果：克隆到一个长度为２２１ｂｐ因ＮｏｔⅠ酶切位点甲基化所致的ＤＮＡ片段,序列分析结果表明其来源于急性白血病相关基因（ＷＩＴ－１基因）第二外显子,ＷＩＴ－１基因甲基化发生率在原发难治性ＡＭＬ中明显     

Deletion of WT1 and WIT1 Genes and Loss of Heterozygosity on Chromosome 11p in Wilms Tumors in Japan

Six of 39 sporadic Wilms tumors had gross homozygous or hemizygous WT1 and WIT1 deletions. Two Wilms tumor-aniridia-genitourinary abnormalities-mental retardation syndrome patients had total hemizygous WT1 and WIT1 deletions in both constitutional and nonsporadic type tumor cells. Four of the 8 tumors with WT1 and WIT1 deletions showed loss of constitutional heterozygosity (LOH) for markers limited to the 11p13 region. Seven of 19 Wilms tumors with neither WT1 nor WIT1 deletions also had LOH on 11p; 4 in the 11p15–11p13 region, one in the 11p15 and possibly also 11p13 regions, and two solely in the 11lp15 region. Thus, 15 of the 41 Wilms tumors (37%) had WT1 and WIT1 deletions or LOH on 11p, and only 2 of the 27 tumors whose nonneoplastic normal tissues were available for study showed LOH limited to the 11p15 region. None of the 7 non-Wilms childhood renal tumors showed WT1 or WIT1 deletions, or LOH on 11p. These data suggest that Japanese Wilms tumors may be characterized by a higher incidence of the gross WT1 deletion and a lower incidence of LOH limited to the 11p15 region than the Caucasian counterparts. These moleculargenetic features may be contributing to the lower incidence of Wilms tumors in Japanese children than in Caucasian ones.     

Impact of the off-clamp endoscopic robot-assisted simple enucleation (ERASE) of clinical T1 renal tumors on the postoperative renal function: Results from a matched-pair comparison

Purpose

To evaluate the surgical and functional outcomes of a matched-paired series of on-clamp vs off-clamp endoscopic robot-assisted simple enucleation (ERASE) and standardized renorraphy in a tertiary referral institution, to search for predictors of functional drop after surgery and to investigate the influence of off-clamp technique in patients presenting these characteristics.

Intelligence related upper alpha desynchronization in a semantic memory task

Recent evidence shows that event-related (upper) alpha desynchronization (ERD) is related to cognitive performance. Several studies observed a positive, some a negative relationship. The latter finding, interpreted in terms of the neural efficiency hypothesis, suggests that good performance is associated with a more 'efficient', smaller extent of cortical activation. Other studies found that ERD increases with semantic processing demands and that this increase is larger for good performers. Studies supporting the neural efficiency hypothesis used tasks that do not specifically require semantic processing. Thus, we assume that the lack of semantic processing demands may at least in part be responsible for the reduced ERD. In the present study we measured ERD during a difficult verbal-semantic task. The findings demonstrate that during semantic processing, more intelligent (as compared to less intelligent) subjects exhibited a significantly larger upper alpha ERD over the left hemisphere. We conclude that more intelligent subjects exhibit a more extensive activation in a semantic processing system and suggest that divergent findings regarding the neural efficiency hypotheses are due to task specific differences in semantic processing demands.