Spontaneous platelet aggregation in type IIB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPIb binding domain

The association of Type IIB von Willebrand disease (vWD) with chronic persistent thrombocytopenia and spontaneous platelet aggregation has recently been recognized. It has been shown that IIB von Willebrand factor (vWF) can initiate platelet aggregation by binding to the platelet glycoprotein (GP) lb receptor and inducing exposure of the GpIIb/IIIa fibrinogen receptor. In this study we demonstrate the increased binding of Type IIB Tampa vWF with normal platelets when compared with nonthrombocytopenic Type IIB vWF. Studies further demonstrate that spontaneous platelet aggregation initiated by IIB Tampa vWF can be blocked by a 52/48-kDa fragment of normal vWF, which contains the binding domain.     

尼莫地平联合茴拉西坦治疗血管性轻度认知障碍患者对认知功能的影响

目的 探讨尼莫地平联合茴拉西坦治疗血管性轻度认知障碍患者对认知功能的影响.方法 将102例血管性轻度认知障碍患者随机分为观察组和对照组各51例,对照组给予尼莫地平治疗,观察组给予尼莫地平联合茴拉西坦治疗,比较两组患者的临床疗效和认知功能变化情况.结果 治疗3个月后观察组总有效率（92.16％）高于对照组（76.47％）,组间差异有统计学意义（P＜0.05）;3个月后观察组MoCA和ADL评分[（18.69±2.47）分、（28.68±5.32）分]均优于对照组[（16.37±1.85）分、（32.46±7.05）分],差异均有统计学意义（均P＜0.05）.结论 尼莫地平联合茴拉西坦治疗血管性轻度认知障碍安全有效,提高了治疗效果,显著改善了患者认知功能,值得临床推广应用.     

Chylothorax after Myocardial Revascularization with Internal Mammary Graft

Chylothorax following an intrapericardial cardiac operation is rare, and we are aware of only 12 reported cases. Nine followed median sternotomy for treatment of congenital heart disorders or acquired valvular disease; more than expected were reoperations (23%). This report documents that this complication may also occur following myocardial revascularization with internal mammary graft and describes the anatomy that makes this possible. This rare complication is important because of the high morbidity of prolonged tube drainage and the fact that nearly half of the affected patients underwent reoperation (5 of 13). Dilated lymphatics exuding chyle have been found at operations undertaken to control lymph fistulas and were located in anterior thymic tissue previously divided by electrocautery. Awareness of the significance of lymph encountered during cardiac operations, particularly during reoperation and near the origin of the internal mammary artery, may alert the surgeon that the stage is set for a disabling complication. Electrocautery may be an unreliable means of control as lymph contains little coagulable material; suture is recommended instead.     

Configuration affects parallel stent grafting results

Objective

A number of adjunctive “off-the-shelf” procedures have been described to treat complex aortic diseases. Our goal was to evaluate parallel stent graft configurations and to determine an optimal formula for these procedures.

Repair of Sinus of Valsalva Aneurysm Associated with Aortoventricular Discontinuity

The case of a patient with unruptured sinus of Valsalva aneurysm with absence of the intervalvular lamina fibrosa is presented. The association of Valsalva aneurysm and aortic subvalvular defects has been explained as a deficiency of elastic tissue at the aortic root or maldevelopment of the fibrous trigone. Valvular aortic insufficiency with histological evidence of myxoid changes required prosthetic replacement. Myxomatous changes in the fibrous trigone and aortic annulus can explain this unusual, complex anomaly. Accurate preoperative diagnosis may require special views and simultaneous left and right injections at cineangiography. Techniques of repair that have been successful are reviewed, and the essential features of adequate correction are outlined.